DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and Zkscan4

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001034204.1	Gene:	Zkscan4 / 544922	MGIID:	3649412	Length:	480	Species:	Mus musculus

Alignment Length:	522	Identity:	129/522 - (24%)
Similarity:	202/522 - (38%)	Gaps:	151/522 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 AVTTTDAEQNTSLI--------KSTISVDLDYEGEG---------EVFDYEL---PDEPVEKTTS 167
            |:....||:.|.|:        .|.::.:..:.|..         ..|.|..   |.:.:.:...
Mouse    10 ALNARSAEEGTGLLVVKVEQEEASPLAEETSWLGSPGPDRSRQRFRAFRYPEAAGPRQALSRLRE 74

  Fly   168 LILQ-VQGNLKDEKEV----VFTQTNVIYEGDDHELEQQIRECN-------LAIFEGVDNEAEII 220
            |..| ::.::..::::    |..|...|..|   ||:..:||.:       :|:.|.:|.:   :
Mouse    75 LCRQWLRPDMHSKEQILELLVLEQFLTILPG---ELQTWVREQHPDSGEEVVALLEYLDRQ---L 133

  Fly   221 TVTAPQVTTRKSAAKLL---------TQQENDKHQTPVGS----------------------KEE 254
            ..|.|||:|.:.:.:||         :|.....|...:.|                      |.|
Mouse   134 DDTPPQVSTGEWSRELLCCKVAVVTPSQDSQSSHCQAMKSLFKHESQESLECSPLQARGLEMKPE 198

  Fly   255 ARELEKEQVPQSAKRTSRRRGVVKQDVPATPPSDAEPSPKQHRLGTQRKLSAPRAGTVNGPSTTS 319
            .|:|.:.:..:..|.......:.:..||.  |:.||.|.::.:|.|.:|
Mouse   199 TRDLPRAEEYRDQKPEQTVCFLGEDTVPI--PTGAEASEQEGKLQTAQK---------------- 245

  Fly   320 GAATTPELKYHCDRCNAGFAVEKSLMIHRR-QKGCINRNYKCNECEKVFVSPDHLAEHQASHGA- 382
              :.|...::.|..|...||....|..|:| ..|  .:.|:|.:|.|.|:....|..||..|..
Mouse   246 --SATGTRRHFCCECGKSFAQSSGLTKHKRIHTG--EKPYECEDCGKTFIGSSALVIHQRVHTGE 306

  Fly   383 --HNCPECGIRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCNIC 445
              :.|.|||                             |||:..|.|..|.|.||||||:.|:.|
Mouse   307 KPYECEECG-----------------------------KVFSHSSNLIKHQRTHTGEKPYECDDC 342

  Fly   446 GKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTH---TGDKP------------ 495
            ||:|||:.:|.:|...|:..|.|:|.||..:|...:.|..|.|.|   |..||
Mouse   343 GKTFTQSCSLLEHHKIHTGEKPFQCNLCGKAFRRSSHLLRHQRIHGDKTAPKPLHGEAWEGQSPV 407

  Fly   496 ------------FECEVCLARFTTSCSLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHTG 548
                        ::|..|...||...||.:||:.||||:||.||.|...||..:.|..|:|:|.|
Mouse   408 AGQGEDVEAPETYQCSECERSFTRRRSLLEHKKIHTGEKPYQCDACGKGFTRTSYLAQHQRSHVG 472

  Fly   549 ER 550
            ::
Mouse   473 KK 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	8/23 (35%)
		COG5048	<357..570	CDD:227381	73/224 (33%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
		C2H2 Zn finger	385..406	CDD:275370	4/20 (20%)
		C2H2 Zn finger	414..434	CDD:275368	7/19 (37%)
		zf-H2C2_2	427..451	CDD:290200	14/23 (61%)
		C2H2 Zn finger	442..490	CDD:275368	19/47 (40%)
		C2H2 Zn finger	470..487	CDD:275368	5/16 (31%)
		zf-H2C2_2	482..507	CDD:290200	10/51 (20%)
		C2H2 Zn finger	498..518	CDD:275368	8/19 (42%)
		zf-H2C2_2	510..534	CDD:290200	13/23 (57%)
		C2H2 Zn finger	526..546	CDD:275368	8/19 (42%)
		zf-H2C2_2	539..563	CDD:290200	5/12 (42%)
		C2H2 Zn finger	554..574	CDD:275368
		C2H2 Zn finger	582..602	CDD:275368
Zkscan4	NP_001034204.1	SCAN	47..155	CDD:128708	23/113 (20%)
		SCAN	47..135	CDD:280241	16/93 (17%)
		zf-C2H2	253..275	CDD:278523	7/21 (33%)
		C2H2 Zn finger	255..275	CDD:275368	7/19 (37%)
		zf-H2C2_2	268..290	CDD:290200	8/23 (35%)
		C2H2 Zn finger	283..303	CDD:275368	7/19 (37%)
		zf-H2C2_2	295..320	CDD:290200	11/53 (21%)
		COG5048	<307..471	CDD:227381	62/192 (32%)
		zf-C2H2	309..331	CDD:278523	11/50 (22%)
		C2H2 Zn finger	311..331	CDD:275368	11/48 (23%)
		zf-H2C2_2	323..348	CDD:290200	14/24 (58%)
		C2H2 Zn finger	339..359	CDD:275368	9/19 (47%)
		zf-H2C2_2	351..376	CDD:290200	9/24 (38%)
		zf-C2H2	365..387	CDD:278523	8/21 (38%)
		C2H2 Zn finger	367..387	CDD:275368	7/19 (37%)
		C2H2 Zn finger	422..442	CDD:275368	8/19 (42%)
		zf-H2C2_2	434..459	CDD:290200	14/24 (58%)
		C2H2 Zn finger	450..470	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910