DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and Insm1

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_058585.2	Gene:	Insm1 / 53626	MGIID:	1859980	Length:	521	Species:	Mus musculus

Alignment Length:	369	Identity:	82/369 - (22%)
Similarity:	134/369 - (36%)	Gaps:	73/369 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   264 PQSAKRTSRRRGVVKQDVPATPPSDAEPSPKQHRLGTQRKL-------SAP------RAGTVNGP 315
            |.:|.|...:|......|...||:.|..:|...:....|||       ::|      :.|.|..|
Mouse   194 PAAALRPPGKRPAPPAAVATEPPAKAAKAPSAKKPKAIRKLHFEDEVTTSPVLGLKIKEGPVEAP 258

  Fly   316 STTSGAATTPELKYHCDRCNAGFAVEKSLMIHRRQKGCINRNYKCNECEKVFVSPDHLAEHQASH 380
            ...:|.||.|..::.|..|...:|...:|..|:..: .:...|:|.||.|||..|.:||.|:..|
Mouse   259 RGRAGGATRPLGEFICQLCKEEYADPFALAQHKCSR-IVRVEYRCPECAKVFSCPANLASHRRWH 322

  Fly   381 GAHNC--------PECGIRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGE 437
            .....        ||...|.:::||...   ....|:..:...:.:      |...|.:
Mouse   323 KPRPVPAAARAPEPEAATRAEAREAAGG---GSSDRDTPSPGGVSE------SGSEDGL------ 372

  Fly   438 KPFVCNICGKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCL 502
              :.|:.|.|.|.:.|.||:|.|.|.:....|                .|.......|...|..|
Mouse   373 --YECHHCAKKFRRQAYLRKHLLAHHQALQAK----------------GAPPPPPPPPPPAEDIL 419

  Fly   503 ARFTTSCSLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDC 567
            |.:......|..:....||   |..:..:..||              :.::||.|.:||..:|..
Mouse   420 AFYAGPDEKAPQEASGDGE---AAGVLGLSATA--------------QCHLCPVCGETFPSKGAQ 467

  Fly   568 QMHQRTHQGERIYICPVCNEEFKSMPEMRSHL-AGHEQHDKRLV 610
            :.|.|.....:::.|..|...|.|.|.:..|: ..|...:::::
Mouse   468 ERHLRLLHAAQVFPCKYCPATFYSSPGLTRHINKCHPSENRQVI 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	5/22 (23%)
		COG5048	<357..570	CDD:227381	48/220 (22%)
		C2H2 Zn finger	360..380	CDD:275368	10/19 (53%)
		C2H2 Zn finger	385..406	CDD:275370	5/28 (18%)
		C2H2 Zn finger	414..434	CDD:275368	2/19 (11%)
		zf-H2C2_2	427..451	CDD:290200	5/23 (22%)
		C2H2 Zn finger	442..490	CDD:275368	12/47 (26%)
		C2H2 Zn finger	470..487	CDD:275368	0/16 (0%)
		zf-H2C2_2	482..507	CDD:290200	5/24 (21%)
		C2H2 Zn finger	498..518	CDD:275368	4/19 (21%)
		zf-H2C2_2	510..534	CDD:290200	4/23 (17%)
		C2H2 Zn finger	526..546	CDD:275368	2/19 (11%)
		zf-H2C2_2	539..563	CDD:290200	5/23 (22%)
		C2H2 Zn finger	554..574	CDD:275368	8/19 (42%)
		C2H2 Zn finger	582..602	CDD:275368	6/20 (30%)
Insm1	NP_058585.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..59
		SNAG domain. /evidence=ECO:0000305\|PubMed:24227653	1..20
		Required and sufficient for interaction with KDM1A. /evidence=ECO:0000250\|UniProtKB:Q01101	2..7
		Necessary for interaction with CCND1. /evidence=ECO:0000250	43..56
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	76..107
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	180..230		9/35 (26%)
		C2H2 Zn finger	274..294	CDD:275368	5/19 (26%)
		C2H2 Zn finger	302..322	CDD:275368	10/19 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	320..369		8/57 (14%)
		zf-C2H2	373..395	CDD:278523	9/21 (43%)
		C2H2 Zn finger	375..395	CDD:275368	9/19 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..419		4/36 (11%)
		C2H2 Zn finger	454..475	CDD:275368	8/20 (40%)
		C2H2 Zn finger	482..503	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910