DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6654 and ZNF107

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001374954.1	Gene:	ZNF107 / 51427	HGNCID:	12887	Length:	896	Species:	Homo sapiens

Alignment Length:	704	Identity:	177/704 - (25%)
Similarity:	277/704 - (39%)	Gaps:	149/704 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 TGPLLSIYDGGSGSCLADMIREFTKTKPRRNDNLPEKVCLSCLSEISNCYTFKIKCENSSRTLRQ 78
            :||.|.       |||.::|        ||:.:..     .|||.:         ..|:||
Human     4 SGPTLE-------SCLTELI--------RRDQSFG-----WCLSGV---------VANNSR---- 35

  Fly    79 LLPNALPEEPDSKVSISCPVATTDQAVQTTSWEPDRCTASVQTDAVTTTDAEQNTSLIKSTISVD 143
                 :|:  ..|.....|:...|.|:: .|.|..:|..:.|.|.......|...:|:...|:|.
Human    36 -----IPQ--GDKWEKKEPLTFKDVAIE-FSLEEWQCLDTAQRDLYRNVLLENYRNLVFLGIAVS 92

  Fly   144 LDY-----EGEGEVFD---YELPDEPVEKTTSLI--LQVQGNLKDEKEVVFTQTNVIYEGDDHEL 198
            ..|     |.:.|.::   :|:..:|...:....  |..:.|:||..:.|..:.....|.::.:|
Human    93 KPYLITCLEQKKEPWNIKRHEMVAKPPVMSFHFAQDLWPEQNIKDSFQKVTLRRYGKCEYENLQL 157

  Fly   199 E---QQIRECNLAIFEGVDNEA-EIITVTAPQVTTRKSAAKLLTQQENDKH--QTPVGSKE-EAR 256
            .   :.:.||  ...:|..|.. :.:|.|..::.......|:..:..|...  :...|:|. :.:
Human   158 RKGCKHVDEC--TGHKGGHNTVNQCLTATPSKIFQCNKYVKVFDKFSNSNRYKRRHTGNKHFKCK 220

  Fly   257 ELEK-----EQVPQSAKRTSRRRGVVKQDVPATPPSDAEPSPKQHRLGTQRK----LSAPRAGTV 312
            |..|     .|:.|. :|...|....|.:......:......|..|:.|..|    ....:|...
Human   221 ECSKSFCVLSQLTQH-RRIHTRVNSYKCEECGKAFNWFSTLTKHKRIHTGEKPYKCEECGKAFNQ 284

  Fly   313 NGPSTTSGAATTPELKYHCDRCNAGFAVEKSLMIHR---------RQKGC--------------- 353
            :...|......|.|....|:.|...|.....|.||:         :.:.|
Human   285 SSQLTRHKIIHTEEKPNKCEECGKAFKQASHLTIHKIIHTGEKPYKYEECGKVFSQSSHLTTQKI 349

  Fly   354 --INRN-YKCNECEKVFVSPDHLAEHQASHGA---HNCPECGIRCDSKEALSKH----------- 401
              ...| |||.||.|.|....:|..|:..|..   :.|.|||...:....|:|.
Human   350 LHTGENLYKCKECGKAFNLFSNLTNHKRIHAGEKPYKCKECGRAFNISSNLNKQEKIHTGGKLNK 414

  Fly   402 ------------MVQGHKRNLRNQ----CNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSFT 450
                        .:..||:.|..:    |..|.|||...|||..|..|||||||:.|..|||:|.
Human   415 CEECDKAFNRSLKLTAHKKILMEEKPYKCEECGKVFNQFSTLTRHKIIHTGEKPYKCKECGKAFN 479

  Fly   451 QNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTSCSLAKHK 515
            |::||.:||..|:..||:|||.|..:|...:.|.:|.:.::|:||::||.|...|..|.:|.:||
Human   480 QSSNLTEHKKIHTAEKSYKCEECGKAFNQHSNLINHRKIYSGEKPYKCEECGKAFNRSSTLTRHK 544

  Fly   516 RKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQGERIY 580
            :.||||:||.|:.|...|:..:.|..|::.||||:||.|..|.|.|.:......|:|.|.||:.|
Human   545 KIHTGEKPYKCEECDRAFSQSSNLTEHKKIHTGEKPYKCEECGKAFNRFSTLTKHKRIHTGEKPY 609

  Fly   581 ICPVCNEEFKSMPEMRSHLAGHEQHDKRLVHFTFLSNKENGSGALEEELNEMTE 634
            .|..|.:.|....::..|         ::||             .:|:||:..|
Human   610 KCEECGKAFNQSYQLTRH---------KIVH-------------TKEKLNKCEE 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071	15/64 (23%)
		C2H2 Zn finger	331..354	CDD:275368	7/48 (15%)
		COG5048	<357..570	CDD:227381	88/243 (36%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
		C2H2 Zn finger	385..406	CDD:275370	6/43 (14%)
		C2H2 Zn finger	414..434	CDD:275368	9/19 (47%)
		zf-H2C2_2	427..451	CDD:290200	14/23 (61%)
		C2H2 Zn finger	442..490	CDD:275368	20/47 (43%)
		C2H2 Zn finger	470..487	CDD:275368	5/16 (31%)
		zf-H2C2_2	482..507	CDD:290200	9/24 (38%)
		C2H2 Zn finger	498..518	CDD:275368	8/19 (42%)
		zf-H2C2_2	510..534	CDD:290200	11/23 (48%)
		C2H2 Zn finger	526..546	CDD:275368	5/19 (26%)
		zf-H2C2_2	539..563	CDD:290200	12/23 (52%)
		C2H2 Zn finger	554..574	CDD:275368	6/19 (32%)
		C2H2 Zn finger	582..602	CDD:275368	4/19 (21%)
ZNF107	NP_001374954.1	KRAB	48..108	CDD:214630	14/60 (23%)
		C2H2 Zn finger	191..211	CDD:275368	2/19 (11%)
		C2H2 Zn finger	219..239	CDD:275368	5/20 (25%)
		COG5048	243..621	CDD:227381	113/377 (30%)
		C2H2 Zn finger	247..267	CDD:275368	2/19 (11%)
		C2H2 Zn finger	275..295	CDD:275368	2/19 (11%)
		C2H2 Zn finger	303..323	CDD:275368	6/19 (32%)
		C2H2 Zn finger	331..351	CDD:275368	1/19 (5%)
		C2H2 Zn finger	359..379	CDD:275368	7/19 (37%)
		C2H2 Zn finger	387..407	CDD:275368	6/19 (32%)
		C2H2 Zn finger	415..435	CDD:275368	2/19 (11%)
		C2H2 Zn finger	443..463	CDD:275368	9/19 (47%)
		C2H2 Zn finger	471..491	CDD:275368	10/19 (53%)
		C2H2 Zn finger	499..519	CDD:275368	6/19 (32%)
		C2H2 Zn finger	527..547	CDD:275368	8/19 (42%)
		COG5048	551..>863	CDD:227381	33/113 (29%)
		C2H2 Zn finger	555..575	CDD:275368	5/19 (26%)
		C2H2 Zn finger	583..603	CDD:275368	6/19 (32%)
		C2H2 Zn finger	611..631	CDD:275368	4/28 (14%)
		C2H2 Zn finger	639..659	CDD:275368	1/3 (33%)
		C2H2 Zn finger	699..715	CDD:275368
		C2H2 Zn finger	723..743	CDD:275368
		C2H2 Zn finger	751..771	CDD:275368
		C2H2 Zn finger	779..799	CDD:275368
		C2H2 Zn finger	807..827	CDD:275368
		C2H2 Zn finger	835..855	CDD:275368
		C2H2 Zn finger	863..883	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000