DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZNF716

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001152751.1	Gene:	ZNF716 / 441234	HGNCID:	32458	Length:	495	Species:	Homo sapiens

Alignment Length:	466	Identity:	137/466 - (29%)
Similarity:	202/466 - (43%)	Gaps:	73/466 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 DHELEQQIRECNLAIFEGVDNEAEI-ITVTAPQVTT----RKSAAKLLTQQENDKHQTPVGSKEE 254
            ||..:...|:   .:.|...|...: |.|:.|.:.|    .|....:...:...||  ||.....
Human    34 DHAQQNLYRD---VMLENYRNLVSLGIAVSKPDLITCLEQNKEPQNIKRNEMVAKH--PVTCSHF 93

  Fly   255 ARELEKEQ-VPQSAKRTSRRR----GVVKQDVPATPPSDAEPSPKQHRLG----------TQRK- 303
            .::|:.|| :..|.::...||    |  ::|:.......:....:.|:.|          ||.|
Human    94 TQDLQSEQGIKDSLQKVILRRYGKCG--QEDLQVKKCCKSVGECEVHKGGYNYVNQCLSATQNKT 156

  Fly   304 LSAPRAGTVNGPSTTSG---AATTPELKYHCDRCNAGFAVEKSL----MIHRRQKGCINRNYKCN 361
            ....:...|.|..:.|.   ...|.:..:.|......|.:...|    :||.|:|     :|||.
Human   157 FQTHKCVKVFGKFSNSNRHKTRHTGKKHFKCKNDGKSFCMLSRLNQHQIIHTREK-----SYKCE 216

  Fly   362 ECEKVFVSPDHLAEHQASHGA---HNCPECGIRCDSKEALSKH---------------------- 401
            ||.|.|.....|..|:..|..   :.|.|||.......:|:||
Human   217 ECGKSFNCSSTLTRHKRIHTGEKPYRCEECGKAFSWSASLTKHKRIHTGEKPYTCEERGKVFSRS 281

  Fly   402 MVQGHKRNLRNQ----CNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSFTQNANLRQHKLRH 462
            .:..:||....:    |..|.|.|:..|||.:|.||||||:|:.|..|||:|:.::.|::||:.|
Human   282 TLTNYKRIHTGEKPYTCEECGKAFSRSSTLTNHKRIHTGERPYKCEECGKAFSLSSTLKKHKIVH 346

  Fly   463 SETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTSCSLAKHKRKHTGERPYACD 527
            :..|.:.||.|..:|...:.|.:|.|.|||:||:.||.|...|:...:...|||.||||:||.|:
Human   347 TGEKLYTCEECGKAFTFSSTLNTHKRIHTGEKPYTCEECGKAFSLPSTFTYHKRTHTGEKPYKCE 411

  Fly   528 LCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQGERIYICPVCNEEFKSM 592
            .|...|...:.||.|:..||||:.|.|..|.|.||.......|:|.|.||:.|.|..|::.||
Human   412 ECGKAFNCSSTLKKHKIIHTGEKLYKCKECGKAFTFSSTLNTHKRIHTGEKPYKCEECDQTFK-- 474

  Fly   593 PEMRSHLAGHE 603
              ..|.||.|:
Human   475 --WHSSLANHK 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	7/26 (27%)
		COG5048	<357..570	CDD:227381	85/241 (35%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
		C2H2 Zn finger	385..406	CDD:275370	7/42 (17%)
		C2H2 Zn finger	414..434	CDD:275368	9/19 (47%)
		zf-H2C2_2	427..451	CDD:290200	14/23 (61%)
		C2H2 Zn finger	442..490	CDD:275368	17/47 (36%)
		C2H2 Zn finger	470..487	CDD:275368	5/16 (31%)
		zf-H2C2_2	482..507	CDD:290200	12/24 (50%)
		C2H2 Zn finger	498..518	CDD:275368	7/19 (37%)
		zf-H2C2_2	510..534	CDD:290200	11/23 (48%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		zf-H2C2_2	539..563	CDD:290200	12/23 (52%)
		C2H2 Zn finger	554..574	CDD:275368	7/19 (37%)
		C2H2 Zn finger	582..602	CDD:275368	7/19 (37%)
ZNF716	NP_001152751.1	KRAB	16..76	CDD:214630	10/44 (23%)
		KRAB	16..55	CDD:279668	5/23 (22%)
		C2H2 Zn finger	160..179	CDD:275368	3/18 (17%)
		C2H2 Zn finger	187..207	CDD:275368	3/19 (16%)
		COG5048	211..>494	CDD:227381	100/282 (35%)
		C2H2 Zn finger	215..235	CDD:275368	7/19 (37%)
		zf-H2C2_2	228..251	CDD:290200	7/22 (32%)
		C2H2 Zn finger	243..263	CDD:275368	7/19 (37%)
		zf-H2C2_2	283..307	CDD:290200	6/23 (26%)
		C2H2 Zn finger	298..318	CDD:275368	9/19 (47%)
		zf-H2C2_2	311..334	CDD:290200	13/22 (59%)
		C2H2 Zn finger	326..346	CDD:275368	8/19 (42%)
		CpXC	353..>398	CDD:291051	16/44 (36%)
		C2H2 Zn finger	354..374	CDD:275368	7/19 (37%)
		C2H2 Zn finger	382..402	CDD:275368	7/19 (37%)
		zf-H2C2_2	398..419	CDD:290200	12/20 (60%)
		C2H2 Zn finger	410..430	CDD:275368	6/19 (32%)
		zf-H2C2_2	423..446	CDD:290200	11/22 (50%)
		C2H2 Zn finger	438..458	CDD:275368	7/19 (37%)
		zf-H2C2_2	451..474	CDD:290200	8/22 (36%)
		C2H2 Zn finger	466..486	CDD:275368	8/22 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910