DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZNF506

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001092739.1	Gene:	ZNF506 / 440515	HGNCID:	23780	Length:	444	Species:	Homo sapiens

Alignment Length:	425	Identity:	127/425 - (29%)
Similarity:	185/425 - (43%)	Gaps:	81/425 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 ITVTAPQ-VTTRKSAAKLLTQQENDK-HQTPVGSKEEARELEKEQ-VPQSAKRTSRRRG------ 275
            |.|:.|. :|..:...|.||.:.::. .:.||.....|::|..|| :..|.::...||.
Human    45 IVVSKPNLITCLEQGKKPLTMKRHEMIAKPPVMYSHFAQDLWSEQSIKDSFQKVILRRYEKCRHD 109

  Fly   276 --VVKQDVPATPPSDAEPSPKQHRLGTQRKLSAPRAGTVNGPSTTSGAATTPELKYHCDRCNAGF 338
              .:|:...:.   |..|..|:...|.::.|                 |||....:.||
Human   110 NLQLKKGCESV---DECPVHKRGYNGLKQCL-----------------ATTQRKIFQCD------ 148

  Fly   339 AVEKSLMIHR---------RQKG-----CI---------------------NRNYKCNECEKVFV 368
              |....:|:         |..|     ||                     .:.|||.||.|.:.
Human   149 --EYVKFLHKFSNSNKHKIRDTGKKSFKCIEYGKTFNQSSTRTTYKKIDAGEKRYKCEECGKAYK 211

  Fly   369 SPDHLAEHQASHGA---HNCPECGIRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLSTLRDH 430
            ...||..|:..|..   :.|.|||........|:.|.:. |......:|..|.|.|...:||..|
Human   212 QSSHLTTHKKIHTGEKPYKCEECGKAYKQSCNLTTHKII-HTGEKPYRCRECGKAFNHPATLFSH 275

  Fly   431 MRIHTGEKPFVCNICGKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKP 495
            .:|||||||:.|:.|||:|..::.|.:|::.|:..|.:|||.|..:|...:.||.|.|.||||.|
Human   276 KKIHTGEKPYKCDKCGKAFISSSTLTKHEIIHTGEKPYKCEECGKAFNRSSNLTKHKRIHTGDVP 340

  Fly   496 FECEVCLARFTTSCSLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKT 560
            ::|:.|...||...||:||||.||||:||.|:.|...|||.:.|..|:..||||:||.|..|.|.
Human   341 YKCDECGKTFTWYSSLSKHKRAHTGEKPYKCEECGKAFTAFSTLTEHKIIHTGEKPYKCEECGKA 405

  Fly   561 FTQRGDCQMHQRTHQGERIYICPVCN-EEFKSMPE 594
            |........|::.|..::  .|.|.| |...::|:
Human   406 FNWSSALNKHKKIHIRQK--PCIVKNVENLLNVPQ 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	6/36 (17%)
		COG5048	<357..570	CDD:227381	87/215 (40%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
		C2H2 Zn finger	385..406	CDD:275370	6/20 (30%)
		C2H2 Zn finger	414..434	CDD:275368	7/19 (37%)
		zf-H2C2_2	427..451	CDD:290200	14/23 (61%)
		C2H2 Zn finger	442..490	CDD:275368	18/47 (38%)
		C2H2 Zn finger	470..487	CDD:275368	6/16 (38%)
		zf-H2C2_2	482..507	CDD:290200	12/24 (50%)
		C2H2 Zn finger	498..518	CDD:275368	10/19 (53%)
		zf-H2C2_2	510..534	CDD:290200	14/23 (61%)
		C2H2 Zn finger	526..546	CDD:275368	7/19 (37%)
		zf-H2C2_2	539..563	CDD:290200	12/23 (52%)
		C2H2 Zn finger	554..574	CDD:275368	5/19 (26%)
		C2H2 Zn finger	582..602	CDD:275368	5/14 (36%)
ZNF506	NP_001092739.1	KRAB	4..62	CDD:214630	4/16 (25%)
		KRAB	6..43	CDD:279668
		C2H2 Zn finger	147..167	CDD:275368	4/27 (15%)
		C2H2 Zn finger	175..195	CDD:275368	2/19 (11%)
		C2H2 Zn finger	203..223	CDD:275368	7/19 (37%)
		zf-H2C2_2	215..240	CDD:290200	8/24 (33%)
		C2H2 Zn finger	231..251	CDD:275368	6/20 (30%)
		zf-H2C2_2	243..268	CDD:290200	7/25 (28%)
		COG5048	<255..417	CDD:227381	71/161 (44%)
		C2H2 Zn finger	259..279	CDD:275368	7/19 (37%)
		zf-H2C2_2	272..296	CDD:290200	14/23 (61%)
		C2H2 Zn finger	287..307	CDD:275368	7/19 (37%)
		zf-H2C2_2	300..324	CDD:290200	9/23 (39%)
		C2H2 Zn finger	315..335	CDD:275368	8/19 (42%)
		zf-H2C2_2	327..351	CDD:290200	11/23 (48%)
		C2H2 Zn finger	343..363	CDD:275368	10/19 (53%)
		zf-H2C2_2	355..379	CDD:290200	14/23 (61%)
		C2H2 Zn finger	371..391	CDD:275368	7/19 (37%)
		zf-H2C2_2	384..407	CDD:290200	11/22 (50%)
		C2H2 Zn finger	399..419	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000