DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6654 and topi

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster

Alignment Length:	717	Identity:	175/717 - (24%)
Similarity:	251/717 - (35%)	Gaps:	246/717 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 RTL-----RQLLPNA------LPEEPDSKV-----SISCPVATTDQAV--------QTTSWEPDR 114
            |||     :|:|..|      .|:....|:     .::....||:|:|        ..::....:
  Fly    74 RTLADPAFKQILQEADGKKGFDPQAEQMKIRDFLAGVTSSKMTTEQSVFHGSRSNSSASTVNRIK 138

  Fly   115 C-TASVQTDAVTTTDAEQNTSLIKSTISVDLDYEGEGE-VFDYELPDEPVEKTTSLILQVQGNLK 177
            | |..||.|||    |.||.|.....|.|.:..:.:.. |.....|..|:.|..|
  Fly   139 CPTCLVQFDAV----AFQNHSCEAKPIEVAVPQQEKPHLVPTVSAPPAPLSKPAS---------- 189

  Fly   178 DEKEVVFTQTNVIYEGDDHELEQQIRECNLAIFEGVDNEAEIITVTAPQVTTRKSAAKLLTQQEN 242
                                 |:.|||..:.:...:.:|.:....|..: ::||:|||
  Fly   190 ---------------------ERVIRENQVRLRRYIKDEMKYDLATGIE-SSRKNAAK------- 225

  Fly   243 DKHQTPVGSKE-------------EARELEKEQVPQSAKRTSRRRGVVKQDVPATPPS------- 287
                   |..|             ..|.:||..:.....:||.:        |.|.|:
  Fly   226 -------GPNECTMCDRKFVHASGLVRHMEKHALDLIPSQTSEQ--------PHTIPAAGLHVVV 275

  Fly   288 ----------------------DAEPSPKQHRLGTQRKLSAPRA--------GTV---NGPS-TT 318
                                  |:|.|..:....||  :.:.||        |.:   |.|: .|
  Fly   276 KCNSCGRIFYDPQVAFRHGLIHDSEHSTMRQSPMTQ--VPSNRADFNELLLDGEMLIDNDPAFAT 338

  Fly   319 SGAATTPELK-----------YHCDRCNAGFAVEKSLMIH-------RR---------------- 349
            |...|.|..|           ..|:.|...||....|::|       ||
  Fly   339 SNQNTNPPKKEMFSSLILGSVLQCEFCEYIFADIAELLVHSASHVAERRFECTACDIQMNTAKEA 403

  Fly   350 ----QKGCI-------------NRNYKCNECEKVFVSPDHLAEHQASHGAHNCPECGIRCDSKEA 397
                |..||             :|.:.||.||..|.:.|.|.||              ||.|...
  Fly   404 SIHFQTDCIFMREAIRSLNVTLSRYFVCNVCELKFANTDLLQEH--------------RCTSFHY 454

  Fly   398 LSKHMVQGHKRNLRNQCNICQKVFTMLSTL-------------RDHMRIHTGE---KPFVCNICG 446
            ..:....|.|  |...|:.|...|......             |:....:||.   :.::|:|||
  Fly   455 FPRLNENGKK--LLLPCDFCDVNFEFAHDFLAHSEEKHLNKKKREKETRNTGAGRIRQYLCDICG 517

  Fly   447 KSFTQNANLRQHKLRHSETKSFKC--ELCPHSFVTKAELTSHAR-THTGDKPFECEVCLARFTTS 508
            ||:||:::|.||...|...|.|.|  |.|...|..:.:|..|.| .|||::|:.|.||..||.|.
  Fly   518 KSYTQSSHLWQHLRFHQGVKPFVCQEENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFLTG 582

  Fly   509 CSLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRT 573
            ....:|:..|.|||.|.|:.|..||...:.||||:|.||||:||.|.||:|||.||||...|.|.
  Fly   583 SVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIRA 647

  Fly   574 H------------QGERIYICPVCNEEFKSMPEMRSHLAGHEQHDKRLVHFTFLSNKENGSGALE 626
            .            |.::..:      |..:..:.:||  ..||.|..:......|:..:|||.:.
  Fly   648 RHSHLDANSRLMMQMQKFQL------ETAAAQKAQSH--NPEQQDNDVAGGASTSDVPSGSGFMS 704

  Fly   627 EE 628
            .|
  Fly   705 TE 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071	3/9 (33%)
		C2H2 Zn finger	331..354	CDD:275368	9/49 (18%)
		COG5048	<357..570	CDD:227381	83/231 (36%)
		C2H2 Zn finger	360..380	CDD:275368	9/19 (47%)
		C2H2 Zn finger	385..406	CDD:275370	3/20 (15%)
		C2H2 Zn finger	414..434	CDD:275368	4/32 (13%)
		zf-H2C2_2	427..451	CDD:290200	9/39 (23%)
		C2H2 Zn finger	442..490	CDD:275368	21/50 (42%)
		C2H2 Zn finger	470..487	CDD:275368	5/18 (28%)
		zf-H2C2_2	482..507	CDD:290200	12/25 (48%)
		C2H2 Zn finger	498..518	CDD:275368	7/19 (37%)
		zf-H2C2_2	510..534	CDD:290200	9/23 (39%)
		C2H2 Zn finger	526..546	CDD:275368	9/19 (47%)
		zf-H2C2_2	539..563	CDD:290200	17/23 (74%)
		C2H2 Zn finger	554..574	CDD:275368	12/19 (63%)
		C2H2 Zn finger	582..602	CDD:275368	3/19 (16%)
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	2/19 (11%)
		C2H2 Zn finger	277..297	CDD:275368	0/19 (0%)
		C2H2 Zn finger	431..453	CDD:275368	12/35 (34%)
		COG5048	<450..647	CDD:227381	73/198 (37%)
		C2H2 Zn finger	469..490	CDD:275368	3/20 (15%)
		zf-C2H2	511..533	CDD:278523	11/21 (52%)
		C2H2 Zn finger	513..564	CDD:275368	21/50 (42%)
		C2H2 Zn finger	541..561	CDD:275368	6/19 (32%)
		zf-H2C2_2	555..581	CDD:290200	12/25 (48%)
		C2H2 Zn finger	572..592	CDD:275368	7/19 (37%)
		zf-H2C2_2	585..609	CDD:290200	10/23 (43%)
		zf-C2H2	598..620	CDD:278523	10/21 (48%)
		C2H2 Zn finger	600..620	CDD:275368	9/19 (47%)
		zf-H2C2_2	612..637	CDD:290200	17/24 (71%)
		C2H2 Zn finger	628..646	CDD:275368	11/17 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24390
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010