DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6654 and CG8301

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster

Alignment Length:	711	Identity:	167/711 - (23%)
Similarity:	244/711 - (34%)	Gaps:	234/711 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CLTCLSSTGPLLSIYDGGSG----------SC----LADMIREFT----KTKPRRNDNLPEKVCL 53
            |.||..|.  .:..::.||.          :|    :|.:..:|.    |..|  ||.||:|:|.
  Fly     4 CRTCAISM--FVCDFENGSNNSHFLDLHHPNCWPSEMAQIRLQFANWNLKISP--NDGLPQKICS 64

  Fly    54 SCLSEISNCYTFKIKCENSSRTLRQLLPNALPEEPDSKVSISCPVATTDQAVQTTSWEPDRCTAS 118
            .|.::..:...|::.|:.:...|..:.         .|:..|                      |
  Fly    65 DCFTKFCSINAFRLACQEAQLKLSHIY---------DKIDAS----------------------S 98

  Fly   119 VQTDAVTTTDAE-----QNTSLIKSTISVDLDYEGEGEVFDYELPDEPVEKTTSLILQVQGNLKD 178
            ::.|.:...|.|     |.|...|.|.:|..:.:......|      |:|
  Fly    99 LEDDEIGQEDLEPAEEHQETETTKPTTTVSAETQPNNTASD------PIE--------------- 142

  Fly   179 EKEVVFTQTNVIYEGDDHELEQQIRECNLAIFEGVDNEAE--IITVTAPQVTTRKSAAK------ 235
                :|.....|.|.::.|.|::.:       :..|.|.|  |...:||...|...|.|
  Fly   143 ----IFVDAVDIDEAEEEEEEEEQQ-------QQYDEEVEEPITDESAPPQLTISYACKFCLRPQ 196

  Fly   236 -------LLTQQENDKH--QTPVGSKE-EARELEKEQVPQSAKRTSRRRGVVKQDVPATPPSDAE 290
                   ||.:..|..|  :.|....| |||      ...:|.||...:.           |..|
  Fly   197 ENYQLQQLLLEHINASHDPEQPYNCPECEAR------FQDAASRTVHLKS-----------SHVE 244

  Fly   291 PSPKQHRLGTQRKLSAPRAGTVNGPSTTSGAATTPELKYH------CDRCNAGFAVEKSLMIHRR 349
               |||..|...|....|....:...           |||      |..|...|...|||..|.:
  Fly   245 ---KQHACGVCGKKYGDRHNLRHHVE-----------KYHSETDFECALCEKRFYTRKSLNYHMK 295

  Fly   350 QKGCINRNYKCNE--CEKVFVSPDHLAEHQASHGAHNCPECGIRCDSKEALSKHMVQGHKRNLRN 412
            ... .:|.:||..  ||::|:|..||..|:|:|..           :....|:|
  Fly   296 WHN-PDRQFKCRHSGCERLFISQRHLMCHEATHSG-----------TSSRKSEH----------- 337

  Fly   413 QCNICQKVFTMLSTLRDHM-RIHTGEKPFVCNICGKSFTQNANLRQHKL-RHSET----KSFKCE 471
             |..|.|.|..|.|||.|: |.|.||||:.|..|.:.|...|..|.|.| ||.|.    :..:|.
  Fly   338 -CGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECM 401

  Fly   472 LCPHSFVTKAELTSHARTHTGDKP-----------------------FECEVCLARFTTSCSLAK 513
            ||...|.::.:|..|.......:|                       |:|..|..||....:|.:
  Fly   402 LCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALER 466

  Fly   514 HKRKHT-GERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTF------TQ-------- 563
            |...|: .:||:||..|..||.....:|.|.:||..|:|.||..|.|.|      ||
  Fly   467 HAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVL 531

  Fly   564 ---------------RGDCQMHQRTHQGERIYICPVCNEEFKSMPEMRSHL----AGHEQH 605
                           ....::|||||.|:..|.|.:|.|.|.:..::::|:    |..:.|
  Fly   532 EKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPH 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071	21/89 (24%)
		C2H2 Zn finger	331..354	CDD:275368	7/22 (32%)
		COG5048	<357..570	CDD:227381	73/273 (27%)
		C2H2 Zn finger	360..380	CDD:275368	9/21 (43%)
		C2H2 Zn finger	385..406	CDD:275370	2/20 (10%)
		C2H2 Zn finger	414..434	CDD:275368	10/20 (50%)
		zf-H2C2_2	427..451	CDD:290200	12/24 (50%)
		C2H2 Zn finger	442..490	CDD:275368	16/52 (31%)
		C2H2 Zn finger	470..487	CDD:275368	5/16 (31%)
		zf-H2C2_2	482..507	CDD:290200	8/47 (17%)
		C2H2 Zn finger	498..518	CDD:275368	6/19 (32%)
		zf-H2C2_2	510..534	CDD:290200	9/24 (38%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		zf-H2C2_2	539..563	CDD:290200	11/29 (38%)
		C2H2 Zn finger	554..574	CDD:275368	9/48 (19%)
		C2H2 Zn finger	582..602	CDD:275368	6/23 (26%)
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	20/86 (23%)
		COG5048	198..>508	CDD:227381	97/364 (27%)
		C2H2 Zn finger	221..241	CDD:275368	7/36 (19%)
		C2H2 Zn finger	249..269	CDD:275368	3/30 (10%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	9/21 (43%)
		C2H2 Zn finger	338..359	CDD:275368	10/20 (50%)
		C2H2 Zn finger	367..384	CDD:275368	5/16 (31%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	6/19 (32%)
		C2H2 Zn finger	537..557	CDD:275368	3/19 (16%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	91	1.000	Inparanoid score	I2264
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.050