DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG6654 and insm1a

DIOPT Version :9

Sequence 1:NP_650429.1 Gene:CG6654 / 41831 FlyBaseID:FBgn0038301 Length:639 Species:Drosophila melanogaster
Sequence 2:NP_991207.1 Gene:insm1a / 402941 ZFINID:ZDB-GENE-040426-1810 Length:383 Species:Danio rerio


Alignment Length:338 Identity:75/338 - (22%)
Similarity:131/338 - (38%) Gaps:50/338 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   174 GNLKDEKEVVFTQTNVIYEGDDHELEQQIRECNLAIFEGVDNEAEIITVTAPQVTTRKSAAKLLT 238
            ||.:.....:::.|..:  ..:||.....|..||    |....||... .||..:.:......:.
Zfish    48 GNPETVYRAMYSPTRPV--SREHERACLERRFNL----GSPISAESFP-AAPNCSDQAPVDLKIG 105

  Fly   239 QQENDKHQTPVGSKEEARELEKEQVPQSAKRTSRRRGVVKQDVPATPPSDAEPSPKQHRLGTQRK 303
            ...:::..|.|.:|..|.:.|::..|.|.|..:.|:...:.::..:|.           ||.:.|
Zfish   106 TSNSNRTGTTVTTKRPASDTERKGKPASKKAKAMRKLQFEDEMTTSPV-----------LGLKIK 159

  Fly   304 LSAPRAGTV-NGPSTTSGAATTPELKYHCDRCNAGFAVEKSLMIHRRQKGCINRNYKCNECEKVF 367
                 .|.| ..|.:...:...|..::.|..|...:|...||..|:..: .:...|:|.||:|:|
Zfish   160 -----EGPVEQKPRSQCASGDKPLGEFVCQLCREAYADPFSLAQHKCSR-IVRIEYRCPECDKLF 218

  Fly   368 VSPDHLAEHQASHGAHN--------CPECGIRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTML 424
            ..|.:||.|:..|....        .||.......::..|..:.:....:....|..|.|.|...
Zfish   219 SCPANLASHRRWHKPKQSAESNKTPAPEKEETSSDRDTPSPGLSESGSEDGLYDCQHCGKKFKRQ 283

  Fly   425 STLRDHMRIH--TGEKP-------------FVCNICGKSFTQNANLRQH-KLRHSETKSFKCELC 473
            :.|:.|:..|  ..|||             .:|.:||::|....:..:| :|:|| .:.:.|:.|
Zfish   284 AYLKKHVTAHHDAPEKPQSHAPLNLSASECHLCPVCGENFPSRMSQERHIRLQHS-AQVYPCKYC 347

  Fly   474 PHSFVTKAELTSH 486
            |..|.:...||.|
Zfish   348 PAMFYSSPGLTRH 360

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6654NP_650429.1 zf-AD 6..79 CDD:285071
C2H2 Zn finger 331..354 CDD:275368 6/22 (27%)
COG5048 <357..570 CDD:227381 39/154 (25%)
C2H2 Zn finger 360..380 CDD:275368 9/19 (47%)
C2H2 Zn finger 385..406 CDD:275370 3/20 (15%)
C2H2 Zn finger 414..434 CDD:275368 6/19 (32%)
zf-H2C2_2 427..451 CDD:290200 10/38 (26%)
C2H2 Zn finger 442..490 CDD:275368 15/46 (33%)
C2H2 Zn finger 470..487 CDD:275368 7/17 (41%)
zf-H2C2_2 482..507 CDD:290200 3/5 (60%)
C2H2 Zn finger 498..518 CDD:275368
zf-H2C2_2 510..534 CDD:290200
C2H2 Zn finger 526..546 CDD:275368
zf-H2C2_2 539..563 CDD:290200
C2H2 Zn finger 554..574 CDD:275368
C2H2 Zn finger 582..602 CDD:275368
insm1aNP_991207.1 SNAG domain. /evidence=ECO:0000250|UniProtKB:Q63ZV0 1..20
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 99..141 8/41 (20%)
C2H2 Zn finger 183..203 CDD:275368 6/19 (32%)
C2H2 Zn finger 211..231 CDD:275368 9/19 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 229..269 4/39 (10%)
zf-C2H2 271..293 CDD:278523 6/21 (29%)
C2H2 Zn finger 273..293 CDD:275368 6/19 (32%)
C2H2 Zn finger 316..335 CDD:275368 5/18 (28%)
C2H2 Zn finger 344..365 CDD:275368 7/17 (41%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.