DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZNF880

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001138906.1	Gene:	ZNF880 / 400713	HGNCID:	37249	Length:	577	Species:	Homo sapiens

Alignment Length:	306	Identity:	117/306 - (38%)
Similarity:	146/306 - (47%)	Gaps:	12/306 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   324 TPELKYHCDRCNAGFAVEKSLMIHRR-QKGCINRNYKCNECEKVFVSPDHLAEHQASHGA---HN 384
            |.|..|.|..|...|.....|..|.| ..|  .:.||||||.|||....|||.||..|..   :.
Human   263 TGEKPYKCHECGKVFTQNSHLANHHRIHTG--EKPYKCNECGKVFNRNAHLARHQKIHSGEKPYK 325

  Fly   385 CPECGIRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSF 449
            |.|||........|:.|:|. |......:||.|.|||...:.|..|.||||||||:.|..|||.|
Human   326 CKECGKAFSGGSGLTAHLVI-HTGEKLYKCNKCGKVFNRNAHLTRHQRIHTGEKPYECKECGKVF 389

  Fly   450 TQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTSCSLAKH 514
            .....|..|...|:..:.:||..|..:|...:.||:|...|||:||::|:.|...|....||:.|
Human   390 RHKFCLTNHHRMHTGEQPYKCNECGKAFRDCSGLTAHLLIHTGEKPYKCKECAKVFRHRLSLSNH 454

  Fly   515 KRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQGERI 579
            :|.||||:||.||.|...||..:.|.||.|.||||:||.|..|.|.|:.......|::.|.||:.
Human   455 QRFHTGEKPYRCDECGKDFTRNSNLANHHRIHTGEKPYKCSECHKVFSHNSHLARHRQIHTGEKS 519

  Fly   580 YICPVCNEEFKSMPEMRSHLAGHEQHDKRLVH-----FTFLSNKEN 620
            |.|..|.:.|.....::.|...|........|     ||..||..|
Human   520 YKCNECGKVFSHKLYLKKHERIHTGEKPYRCHECGKDFTRNSNLAN 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	7/23 (30%)
		COG5048	<357..570	CDD:227381	91/215 (42%)
		C2H2 Zn finger	360..380	CDD:275368	12/19 (63%)
		C2H2 Zn finger	385..406	CDD:275370	7/20 (35%)
		C2H2 Zn finger	414..434	CDD:275368	9/19 (47%)
		zf-H2C2_2	427..451	CDD:290200	15/23 (65%)
		C2H2 Zn finger	442..490	CDD:275368	15/47 (32%)
		C2H2 Zn finger	470..487	CDD:275368	5/16 (31%)
		zf-H2C2_2	482..507	CDD:290200	11/24 (46%)
		C2H2 Zn finger	498..518	CDD:275368	7/19 (37%)
		zf-H2C2_2	510..534	CDD:290200	13/23 (57%)
		C2H2 Zn finger	526..546	CDD:275368	9/19 (47%)
		zf-H2C2_2	539..563	CDD:290200	14/23 (61%)
		C2H2 Zn finger	554..574	CDD:275368	5/19 (26%)
		C2H2 Zn finger	582..602	CDD:275368	4/19 (21%)
ZNF880	NP_001138906.1	KRAB	7..65	CDD:214630
		KRAB	7..46	CDD:279668
		COG5048	162..568	CDD:227381	117/306 (38%)
		C2H2 Zn finger	186..206	CDD:275368
		zf-C2H2	212..234	CDD:278523
		C2H2 Zn finger	214..234	CDD:275368
		zf-H2C2_2	226..251	CDD:290200
		C2H2 Zn finger	242..262	CDD:275368
		zf-H2C2_2	255..279	CDD:290200	6/15 (40%)
		C2H2 Zn finger	270..290	CDD:275368	6/19 (32%)
		zf-H2C2_2	282..307	CDD:290200	13/26 (50%)
		C2H2 Zn finger	298..318	CDD:275368	12/19 (63%)
		zf-H2C2_2	310..334	CDD:290200	10/23 (43%)
		C2H2 Zn finger	326..346	CDD:275368	7/20 (35%)
		zf-C2H2	352..374	CDD:278523	9/21 (43%)
		C2H2 Zn finger	354..374	CDD:275368	9/19 (47%)
		zf-H2C2_2	366..391	CDD:290200	15/24 (63%)
		C2H2 Zn finger	382..402	CDD:275368	7/19 (37%)
		C2H2 Zn finger	410..430	CDD:275368	6/19 (32%)
		C2H2 Zn finger	438..458	CDD:275368	7/19 (37%)
		zf-H2C2_2	450..475	CDD:290200	14/24 (58%)
		C2H2 Zn finger	466..486	CDD:275368	9/19 (47%)
		zf-H2C2_2	478..503	CDD:290200	14/24 (58%)
		C2H2 Zn finger	494..514	CDD:275368	5/19 (26%)
		zf-H2C2_2	506..531	CDD:290200	8/24 (33%)
		C2H2 Zn finger	522..542	CDD:275368	4/19 (21%)
		zf-H2C2_2	534..559	CDD:290200	4/24 (17%)
		C2H2 Zn finger	550..570	CDD:275368	6/16 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000