DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZNF324B

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_997278.2	Gene:	ZNF324B / 388569	HGNCID:	33107	Length:	544	Species:	Homo sapiens

Alignment Length:	491	Identity:	140/491 - (28%)
Similarity:	198/491 - (40%)	Gaps:	97/491 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 TISVDLDYEGEGEVFDYELPDEPVEKTTSLI-----------LQVQGNLKDEKEVVFTQTNVIYE 192
            :::.|.|..||   :....||.|...|||:.           ||.|......:|...|..:|||.
Human    83 SLTEDRDVSGE---WPRAFPDTPPGMTTSVFPVADACHSVKSLQRQPGASPSQERKPTGVSVIYW 144

  Fly   193 GDDHELEQQIRECNLAIFEGVDNEAEIITVTAPQVTTRKSAAKLLTQQENDKHQTPVGSKEEARE 257
            .            .|.:....|..:..:.:|:|.                   :.|..|:...:.
Human   145 E------------RLLLGSRSDQASISLRLTSPL-------------------RPPKSSRPREKT 178

  Fly   258 LEKEQVPQSAKRTSRRRGVVKQDVPATP---PSD--AEPSPKQHRLGT-----QRKLSAPRAGTV 312
            ..:.:||....||..|:....|:||...   .||  |....:..|:|.     .|.|......|.
Human   179 FTEYRVPGRQPRTPERQKPCAQEVPGRAFGNASDLKAASGGRDRRMGAAWQEPHRLLGGQEPSTW 243

  Fly   313 N--GPSTTSGAATTPELKYHCDRCNAGFAVEKSLMIH-RRQKGCINRNYKCNECEKVFVSPDHLA 374
            :  |.:..:|     |..:.|..|:..|.....|:.| |...|  .|.|:|.:|.|.|....||.
Human   244 DELGEALHAG-----EKSFECRACSKVFVKSSDLLKHLRTHTG--ERPYECTQCGKAFSQTSHLT 301

  Fly   375 EHQASHGA---HNCPECGIRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTG 436
            :||..|..   :.||.||                             |.|...|:|..|.||||.
Human   302 QHQRIHSGETPYACPVCG-----------------------------KAFRHSSSLVRHQRIHTA 337

  Fly   437 EKPFVCNICGKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVC 501
            ||.|.|:.|||:|:..:||.||:..|:..:.:.|..|...|...:.|..|.|||||:|||.|.:|
Human   338 EKSFRCSECGKAFSHGSNLSQHRKIHAGGRPYACAQCGRRFCRNSHLIQHERTHTGEKPFVCALC 402

  Fly   502 LARFTTSCSLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGD 566
            .|.|:...||..|:|.||||:|:||..|...|:..:.|..|:..||||||:.|..|.|.|.:...
Human   403 GAAFSQGSSLFLHQRVHTGEKPFACAQCGRSFSRSSNLTQHQLLHTGERPFRCVDCGKGFAKGAV 467

  Fly   567 CQMHQRTHQGERIYICPVCNEEFKSMPEMRSHLAGH 602
            ...|:|.|.||:.::|..|...|:..|.:..|...|
Human   468 LLSHRRIHTGEKPFVCTQCGRAFRERPALLHHQRIH 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	7/23 (30%)
		COG5048	<357..570	CDD:227381	78/215 (36%)
		C2H2 Zn finger	360..380	CDD:275368	8/19 (42%)
		C2H2 Zn finger	385..406	CDD:275370	4/20 (20%)
		C2H2 Zn finger	414..434	CDD:275368	6/19 (32%)
		zf-H2C2_2	427..451	CDD:290200	14/23 (61%)
		C2H2 Zn finger	442..490	CDD:275368	16/47 (34%)
		C2H2 Zn finger	470..487	CDD:275368	4/16 (25%)
		zf-H2C2_2	482..507	CDD:290200	14/24 (58%)
		C2H2 Zn finger	498..518	CDD:275368	8/19 (42%)
		zf-H2C2_2	510..534	CDD:290200	12/23 (52%)
		C2H2 Zn finger	526..546	CDD:275368	5/19 (26%)
		zf-H2C2_2	539..563	CDD:290200	12/23 (52%)
		C2H2 Zn finger	554..574	CDD:275368	6/19 (32%)
		C2H2 Zn finger	582..602	CDD:275368	5/19 (26%)
ZNF324B	NP_997278.2	KRAB	1..61	CDD:214630
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	184..222		11/37 (30%)
		C2H2 Zn finger	259..279	CDD:275368	6/19 (32%)
		COG5048	<268..499	CDD:227381	92/261 (35%)
		C2H2 Zn finger	287..307	CDD:275368	8/19 (42%)
		C2H2 Zn finger	315..335	CDD:275368	10/48 (21%)
		C2H2 Zn finger	343..363	CDD:275368	9/19 (47%)
		C2H2 Zn finger	371..391	CDD:275368	6/19 (32%)
		C2H2 Zn finger	399..419	CDD:275368	8/19 (42%)
		C2H2 Zn finger	427..447	CDD:275368	5/19 (26%)
		C2H2 Zn finger	455..475	CDD:275368	6/19 (32%)
		C2H2 Zn finger	483..503	CDD:275368	5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	508..544
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149928
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840