DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6654 and ZNF470

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001001668.3	Gene:	ZNF470 / 388566	HGNCID:	22220	Length:	717	Species:	Homo sapiens

Alignment Length:	285	Identity:	113/285 - (39%)
Similarity:	156/285 - (54%)	Gaps:	24/285 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   331 CDRCNAGFAVEKSLMIHRR-QKGCINRNYKCNECEKVFVSPDHLAEHQASHGAH---NCPECGIR 391
            |:.|...|:...:|.:|:| ..|  .:.|:|.||.|.|....|||:||..|...   .|.|||
Human   230 CNDCEKIFSKISTLTLHQRIHTG--EKPYECIECGKAFSQSAHLAQHQRIHTGEKPFECTECG-- 290

  Fly   392 CDSKEALSK--HMVQGHKR----NLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSFT 450
                :|.|:  |:|| |:|    ....||..|.|.|:.|:.|..|.|:||||||:.|..|||:|:
Human   291 ----KAFSQNAHLVQ-HQRVHTGEKPYQCKQCNKAFSQLAHLAQHQRVHTGEKPYECIECGKAFS 350

  Fly   451 QNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHAR-THTGDKPFECEVCLARFTTSCSLAKH 514
            ..::|..|:..|:..:.::|..|..:|...|.|..|.| .|||:|||:|..|...||....|.:|
Human   351 DCSSLAHHRRIHTGKRPYECIDCGKAFRQNASLIRHRRYYHTGEKPFDCIDCGKAFTDHIGLIQH 415

  Fly   515 KRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQGERI 579
            ||.|||||||.|::|...|:..:.|..|:|.||||:||.|..|.|.|:.||...:|||.|.||:.
Human   416 KRTHTGERPYKCNVCGKAFSHGSSLTVHQRIHTGEKPYECNICEKAFSHRGSLTLHQRVHTGEKP 480

  Fly   580 YICPVCNEEFKSMPEMRSHLAGHEQ 604
            |.|..|.:.|:    ..:|||.|::
Human   481 YECKECGKAFR----QSTHLAHHQR 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	7/23 (30%)
		COG5048	<357..570	CDD:227381	92/222 (41%)
		C2H2 Zn finger	360..380	CDD:275368	10/19 (53%)
		C2H2 Zn finger	385..406	CDD:275370	9/22 (41%)
		C2H2 Zn finger	414..434	CDD:275368	8/19 (42%)
		zf-H2C2_2	427..451	CDD:290200	14/23 (61%)
		C2H2 Zn finger	442..490	CDD:275368	15/48 (31%)
		C2H2 Zn finger	470..487	CDD:275368	5/16 (31%)
		zf-H2C2_2	482..507	CDD:290200	12/25 (48%)
		C2H2 Zn finger	498..518	CDD:275368	8/19 (42%)
		zf-H2C2_2	510..534	CDD:290200	13/23 (57%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		zf-H2C2_2	539..563	CDD:290200	13/23 (57%)
		C2H2 Zn finger	554..574	CDD:275368	9/19 (47%)
		C2H2 Zn finger	582..602	CDD:275368	6/19 (32%)
ZNF470	NP_001001668.3	KRAB	23..83	CDD:214630
		KRAB	23..62	CDD:279668
		Nuclear localization signal. /evidence=ECO:0000255	216..219
		C2H2 Zn finger	230..250	CDD:275368	6/19 (32%)
		zf-H2C2_2	243..267	CDD:290200	10/25 (40%)
		COG5048	254..669	CDD:227381	106/259 (41%)
		C2H2 Zn finger	258..278	CDD:275368	10/19 (53%)
		zf-H2C2_2	270..295	CDD:290200	11/30 (37%)
		C2H2 Zn finger	286..306	CDD:275368	11/26 (42%)
		zf-H2C2_2	298..323	CDD:290200	10/25 (40%)
		C2H2 Zn finger	314..334	CDD:275368	8/19 (42%)
		zf-H2C2_2	326..350	CDD:290200	13/23 (57%)
		C2H2 Zn finger	342..362	CDD:275368	7/19 (37%)
		zf-H2C2_2	354..379	CDD:290200	6/24 (25%)
		C2H2 Zn finger	370..388	CDD:275368	6/17 (35%)
		Nuclear localization signal. /evidence=ECO:0000255	385..388		1/2 (50%)
		C2H2 Zn finger	399..419	CDD:275368	8/19 (42%)
		zf-H2C2_2	412..436	CDD:290200	14/23 (61%)
		C2H2 Zn finger	427..447	CDD:275368	6/19 (32%)
		zf-H2C2_2	439..464	CDD:290200	13/24 (54%)
		C2H2 Zn finger	455..475	CDD:275368	9/19 (47%)
		zf-H2C2_2	467..492	CDD:290200	10/28 (36%)
		C2H2 Zn finger	483..503	CDD:275368	7/23 (30%)
		zf-H2C2_2	495..520	CDD:290200	4/7 (57%)
		C2H2 Zn finger	511..531	CDD:275368
		zf-H2C2_2	523..548	CDD:290200
		C2H2 Zn finger	539..559	CDD:275368
		zf-H2C2_2	551..575	CDD:290200
		C2H2 Zn finger	567..587	CDD:275368
		C2H2 Zn finger	595..615	CDD:275368
		zf-H2C2_2	607..632	CDD:290200
		C2H2 Zn finger	623..643	CDD:275368
		zf-H2C2_2	635..660	CDD:290200
		C2H2 Zn finger	651..671	CDD:275368
		zf-H2C2_2	663..688	CDD:290200
		C2H2 Zn finger	679..699	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910