DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG6654 and CTCF

DIOPT Version :9

Sequence 1:NP_650429.1 Gene:CG6654 / 41831 FlyBaseID:FBgn0038301 Length:639 Species:Drosophila melanogaster
Sequence 2:NP_648109.1 Gene:CTCF / 38817 FlyBaseID:FBgn0035769 Length:818 Species:Drosophila melanogaster


Alignment Length:635 Identity:147/635 - (23%)
Similarity:218/635 - (34%) Gaps:158/635 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 GSCLADMIREFTKTKPRRNDNLPEKVCLSCLSEISNCYTFKIKCENSSRTLRQLLPNALPEEPDS 90
            |:|       :.||.|::...|.:|:              |.......:..|.::..|..:..:.
  Fly    91 GNC-------YIKTTPKKQKELQKKL--------------KQAAAKPGKATRSVVSTATNKSINL 134

  Fly    91 KVSISCPVATTDQAVQTTSWEPDRCTASVQTDAVTTTDAEQN---------------------TS 134
            :.:.|.|.|||.:.      .|:....||:........|:|:                     ..
  Fly   135 RPAKSTPKATTSKP------PPEPKAISVRPARAAAAKAKQSAMPPPPALVVKVPAPRGRPRKNP 193

  Fly   135 LIKSTISVDLDYEGEGEVFDYELPDEPVEKTTSLILQVQGNLKDEKEVVFTQTNVIYEGDDHELE 199
            :|.....:||:.|.|      ||.|||  ..:|::.::.....||..|                 
  Fly   194 VIPKPEPMDLERELE------ELVDEP--DISSMVTELSDYTVDEAAV----------------- 233

  Fly   200 QQIRECNLAIFEGVDNEAEIITVTAPQVTTRKSAAKLLTQQEN-DKHQTPVGSKEEARELEKEQV 263
                            ||...|:|..:....:......|:.|| ||       |:....|..::|
  Fly   234 ----------------EAATATLTPNEAEVYEFEDNATTEDENADK-------KDVDFVLSNKEV 275

  Fly   264 P-QSAKRTSRRRGVVKQDVPATPPSDAEPSPKQHRLGTQRKLSAPRAGTVNGPSTTS-------- 319
            . ::|..||                       |:...:..|.|.|..     |.|.|        
  Fly   276 KLKTASSTS-----------------------QNSNASGHKYSCPHC-----PYTASKKFLITRH 312

  Fly   320 GAATTPELKYHCDRCNAGFAVEKSLMIH-RRQKGCINRNYKCNECEKVFVSPDHLAEH----QAS 379
            ..:...|..:.|..|...|.....|..| ....|  |:.:||..||..|.:...|..|    ...
  Fly   313 SRSHDVEPSFKCSICERSFRSNVGLQNHINTHMG--NKPHKCKLCESAFTTSGELVRHTRYKHTK 375

  Fly   380 HGAHNCPECGIRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCNI 444
            ...|.|.||.........|.:||. .|......||..|......:..|:.||.||||||.:.|:|
  Fly   376 EKPHKCTECTYASVELTKLRRHMT-CHTGERPYQCPHCTYASQDMFKLKRHMVIHTGEKKYQCDI 439

  Fly   445 CGKSFTQNANLRQHKLRHS--ETKSFKCELCPHSFVTKAELTSHAR-THTGDKPFECEVCLARFT 506
            |...|||:.:|:.|||.||  :...|:|..||.:...||:|..|.: .||.|.|..|..|..:..
  Fly   440 CKSRFTQSNSLKAHKLIHSVVDKPVFQCNYCPTTCGRKADLRVHIKHMHTSDVPMTCRRCGQQLP 504

  Fly   507 TSCSLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMH- 570
            .......|.:.|.||:.|:|.||.........|.:|...|..|:|:.|..|.:.|.||...:.| 
  Fly   505 DRYQYKLHVKSHEGEKCYSCKLCSYASVTQRHLASHMLIHLDEKPFHCDQCPQAFRQRQLLRRHM 569

  Fly   571 --------QRTHQGERIYICPVCNEEFKSMPEMRSHLAGHEQ----HDKR 608
                    |.....|:::.||.|..||.....:..|:..|:.    .:||
  Fly   570 NLVHNEEYQPPEPREKLHKCPSCPREFTHKGNLMRHMETHDDSANAREKR 619

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6654NP_650429.1 zf-AD 6..79 CDD:285071 9/52 (17%)
C2H2 Zn finger 331..354 CDD:275368 6/23 (26%)
COG5048 <357..570 CDD:227381 71/219 (32%)
C2H2 Zn finger 360..380 CDD:275368 6/23 (26%)
C2H2 Zn finger 385..406 CDD:275370 6/20 (30%)
C2H2 Zn finger 414..434 CDD:275368 5/19 (26%)
zf-H2C2_2 427..451 CDD:290200 13/23 (57%)
C2H2 Zn finger 442..490 CDD:275368 20/50 (40%)
C2H2 Zn finger 470..487 CDD:275368 6/16 (38%)
zf-H2C2_2 482..507 CDD:290200 8/25 (32%)
C2H2 Zn finger 498..518 CDD:275368 3/19 (16%)
zf-H2C2_2 510..534 CDD:290200 8/23 (35%)
C2H2 Zn finger 526..546 CDD:275368 5/19 (26%)
zf-H2C2_2 539..563 CDD:290200 8/23 (35%)
C2H2 Zn finger 554..574 CDD:275368 7/28 (25%)
C2H2 Zn finger 582..602 CDD:275368 6/19 (32%)
CTCFNP_648109.1 23ISL <116..206 CDD:293226 15/95 (16%)
C2H2 Zn finger 296..316 CDD:275368 4/24 (17%)
COG5048 321..>621 CDD:227381 90/302 (30%)
zf-C2H2 322..344 CDD:278523 5/21 (24%)
C2H2 Zn finger 324..344 CDD:275368 5/19 (26%)
zf-H2C2_2 337..361 CDD:290200 9/25 (36%)
C2H2 Zn finger 352..373 CDD:275368 6/20 (30%)
C2H2 Zn finger 381..401 CDD:275368 6/20 (30%)
zf-H2C2_2 394..415 CDD:290200 7/21 (33%)
C2H2 Zn finger 409..429 CDD:275368 5/19 (26%)
zf-H2C2_2 422..446 CDD:290200 13/23 (57%)
C2H2 Zn finger 437..457 CDD:275368 10/19 (53%)
C2H2 Zn finger 467..485 CDD:275368 7/17 (41%)
C2H2 Zn finger 496..516 CDD:275370 3/19 (16%)
C2H2 Zn finger 524..544 CDD:275368 5/19 (26%)
zf-H2C2_2 536..561 CDD:290200 8/24 (33%)
C2H2 Zn finger 552..573 CDD:275368 6/20 (30%)
zf-C2H2 587..609 CDD:278523 6/21 (29%)
C2H2 Zn finger 589..609 CDD:275368 6/19 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR24390
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
11.100

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