DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and Gm5141

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001242994.1	Gene:	Gm5141 / 380850	MGIID:	3779466	Length:	581	Species:	Mus musculus

Alignment Length:	413	Identity:	131/413 - (31%)
Similarity:	198/413 - (47%)	Gaps:	53/413 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   241 ENDKHQTPVGSKEEARELEKEQVPQSAKRTSRRRGVVKQDVPATPPSD-----------AEPSPK 294
            |..::.:.:|...||:.:|:.      .::|||....::...|..||:           |....:
Mouse    35 ETYRNLSALGFSWEAQNIEEH------CQSSRRHRRCERSQSAEKPSEYTQHGKAFAFHAHSHAQ 93

  Fly   295 QH-RLGTQRKLSAPRAGTVNG--PSTT---SGAATTPELKYHCDRCNAGFAVEKSLMIHRRQKGC 353
            :| |:.|: |:.:.....:..  |.|:   ...|.|.:.:|...:|..|||....|..|.|.. .
Mouse    94 RHERIHTE-KIPSEVIHCIEDFLPYTSLQVHKRAQTGQKQYEYKQCGKGFACPSLLKRHERIH-T 156

  Fly   354 INRNYKCNECEKVFVSPDHLAEHQASHGAH---NCPECGIRCDSKEALSKHM-VQGHKRNLRNQ- 413
            :.:.||||:|:|.|.....|..|..:|...   .|.:|      ::|.|.|. :|.|:|....:
Mouse   157 VEKPYKCNQCDKAFSLKYSLQRHIRTHTGEKPFKCNQC------EKAFSHHCNLQTHRRTHTREK 215

  Fly   414 ---CNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSFTQNANLRQHKLRHSETKSFKCELCPH 475
               ||.|.|.|:....|::|.|.|||||||.||.|.|:|::..:|::|...|:..|.:||..|..
Mouse   216 PFKCNECDKAFSQFGNLQNHRRTHTGEKPFKCNECDKAFSEKGSLQKHISIHTGEKPYKCNQCDK 280

  Fly   476 SFVTKAELTSHARTHTGDKPFECEVCLARFTTSCSLAKHKRKHTGERPYACDLCPMRFTALNVLK 540
            :|..|..|..|.|.|||:||::|..|...|:....|..|.|.|:||:||.|:||...|:....|:
Mouse   281 AFSHKQSLLIHIRIHTGEKPYKCNQCDKAFSHKHILKNHIRIHSGEKPYKCNLCDKVFSRHFHLQ 345

  Fly   541 NHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQGERIYICPVCNEEFKSMPEMRSHLAGH--- 602
            ||.||||||:||.|..|.|.|:.....|.|::||.||:.:.|..|::.|.....::||:..|
Mouse   346 NHIRTHTGEKPYRCNQCDKAFSHHKTLQTHRKTHTGEKPFKCNECDKAFSEKGSLQSHIRTHTGE 410

  Fly   603 -----EQHDKRLVHFTFLSNKEN 620
                 .|.||...|      |:|
Mouse   411 KPYKCNQCDKAFSH------KQN 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	7/22 (32%)
		COG5048	<357..570	CDD:227381	86/220 (39%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
		C2H2 Zn finger	385..406	CDD:275370	6/21 (29%)
		C2H2 Zn finger	414..434	CDD:275368	8/19 (42%)
		zf-H2C2_2	427..451	CDD:290200	15/23 (65%)
		C2H2 Zn finger	442..490	CDD:275368	17/47 (36%)
		C2H2 Zn finger	470..487	CDD:275368	5/16 (31%)
		zf-H2C2_2	482..507	CDD:290200	11/24 (46%)
		C2H2 Zn finger	498..518	CDD:275368	6/19 (32%)
		zf-H2C2_2	510..534	CDD:290200	11/23 (48%)
		C2H2 Zn finger	526..546	CDD:275368	8/19 (42%)
		zf-H2C2_2	539..563	CDD:290200	15/23 (65%)
		C2H2 Zn finger	554..574	CDD:275368	6/19 (32%)
		C2H2 Zn finger	582..602	CDD:275368	5/19 (26%)
Gm5141	NP_001242994.1	KRAB	4..>45	CDD:214630	1/9 (11%)
		KRAB	4..43	CDD:279668	1/7 (14%)
		C2H2 Zn finger	136..155	CDD:275368	7/18 (39%)
		zf-H2C2_2	148..171	CDD:290200	9/23 (39%)
		C2H2 Zn finger	163..183	CDD:275368	7/19 (37%)
		zf-H2C2_2	175..200	CDD:290200	6/30 (20%)
		COG5048	187..566	CDD:227381	93/253 (37%)
		C2H2 Zn finger	191..211	CDD:275368	8/25 (32%)
		zf-H2C2_2	203..228	CDD:290200	8/24 (33%)
		C2H2 Zn finger	219..239	CDD:275368	8/19 (42%)
		zf-H2C2_2	231..255	CDD:290200	14/23 (61%)
		C2H2 Zn finger	247..267	CDD:275368	7/19 (37%)
		zf-H2C2_2	259..284	CDD:290200	8/24 (33%)
		C2H2 Zn finger	275..295	CDD:275368	7/19 (37%)
		zf-H2C2_2	287..312	CDD:290200	11/24 (46%)
		C2H2 Zn finger	303..323	CDD:275368	6/19 (32%)
		zf-H2C2_2	316..340	CDD:290200	12/23 (52%)
		C2H2 Zn finger	331..351	CDD:275368	8/19 (42%)
		zf-H2C2_2	343..368	CDD:290200	15/24 (63%)
		C2H2 Zn finger	359..379	CDD:275368	6/19 (32%)
		zf-H2C2_2	372..395	CDD:290200	8/22 (36%)
		C2H2 Zn finger	387..407	CDD:275368	5/19 (26%)
		zf-H2C2_2	399..424	CDD:290200	6/24 (25%)
		C2H2 Zn finger	415..435	CDD:275368	6/19 (32%)
		zf-H2C2_2	427..452	CDD:290200	1/1 (100%)
		C2H2 Zn finger	443..463	CDD:275368
		zf-H2C2_2	455..480	CDD:290200
		C2H2 Zn finger	471..491	CDD:275368
		C2H2 Zn finger	499..519	CDD:275368
		zf-H2C2_2	511..536	CDD:290200
		C2H2 Zn finger	527..547	CDD:275368
		zf-H2C2_2	539..564	CDD:290200
		C2H2 Zn finger	555..575	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910