DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6654 and ZNF568

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_940941.2	Gene:	ZNF568 / 374900	HGNCID:	25392	Length:	644	Species:	Homo sapiens

Alignment Length:	611	Identity:	152/611 - (24%)
Similarity:	254/611 - (41%)	Gaps:	103/611 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 SC--LSEISNCYTFKIKCENSSRTLRQLLPNALPEEPDSKVSISCPVATTDQAVQTT--SWEPDR 114
            ||  :..:|:....|..|...|         ||.||.:........|...|.||..|  .||..:
Human    11 SCVTMERLSHMMERKAWCSQES---------ALSEEEEDTTRPLETVTFKDVAVDLTQEEWEQMK 66

  Fly   115 CTASVQTDAVTTTDAEQNTSLIKSTISV---DLDYEGEGEVFDYELPDEPVEKTTSLILQVQGNL 176
               ..|.:.......|..::|:.....|   |:.::.|.|...:.:.:|...:....:.:|...:
Human    67 ---PAQRNLYRDVMLENYSNLVTVGCQVTKPDVIFKLEQEEEPWVMEEEMFGRHCPEVWEVDEQI 128

  Fly   177 KDEKEVVFTQTNVIYEGDDHELEQQIRECNLAIFEGVDNEAEIITVTAPQVTTRKSAAKLLTQQE 241
            |.::|.:..:...|  .....:::::.||.        ..|:|..:::..||:|:|.....:..:
Human   129 KKQQETLVRKVTSI--SKKILIKEKVIECK--------KVAKIFPLSSDIVTSRQSFYDCDSLDK 183

  Fly   242 NDKHQTPVGSKEEARELEKE-------------------QVPQSAKRTSRRRGVVKQ------DV 281
            ..:|...:...|:....||:                   :..|..:..|.:..:::.      :.
Human   184 GLEHNLDLLRYEKGCVREKQSNEFGKPFYHCASYVVTPFKCNQCGQDFSHKFDLIRHERIHAGEK 248

  Fly   282 PATPPSDAEPSPKQHRLGTQRKLSAPRAGTVNGPSTTSGAATTPELKYHCDRCNAGFAVEKSLMI 346
            |.......:...::..|.|.:|:.                  |.|..|.|:.|...|....:|:.
Human   249 PYECKECGKAFSRKENLITHQKIH------------------TGEKPYKCNECGKAFIQMSNLIR 295

  Fly   347 HRR------------------QKGCI---------NRNYKCNECEKVFVSPDHLAEHQASHGA-- 382
            |.|                  ||..:         .:.|:|.||.|.|....:|.||:..|..
Human   296 HHRIHTGEKPYACKDCWKAFSQKSNLIEHERIHTGEKPYECKECGKSFSQKQNLIEHEKIHTGEK 360

  Fly   383 -HNCPECGIRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCNICG 446
             :.|.|||.......:::.|| :.|......:||.|.|.|:..|....|||.||||||:||:.||
Human   361 PYACNECGRAFSRMSSVTLHM-RSHTGEKPYKCNKCGKAFSQCSVFIIHMRSHTGEKPYVCSECG 424

  Fly   447 KSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTSCSL 511
            |:|:|:::|..|...|:..|.::|:.|..:|..|..|.:|.:.|||:||:||..|...|....:|
Human   425 KAFSQSSSLTVHMRNHTAEKPYECKECGKAFSRKENLITHQKIHTGEKPYECSECGKAFIQMSNL 489

  Fly   512 AKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQG 576
            .:|:|.||||:||||.:|...|:..:.|..|.:.||||:||.|..|.|.|:||.:...|::.|.|
Human   490 IRHQRIHTGEKPYACTVCGKAFSQKSNLTEHEKIHTGEKPYHCNQCGKAFSQRQNLLEHEKIHTG 554

  Fly   577 ERIYICPVCNEEFKSMPEMRSHLAGH 602
            |:.:.|..|.:.|..:..:..|:..|
Human   555 EKPFKCNECGKAFSRISSLTLHVRSH 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071	6/26 (23%)
		C2H2 Zn finger	331..354	CDD:275368	8/40 (20%)
		COG5048	<357..570	CDD:227381	85/215 (40%)
		C2H2 Zn finger	360..380	CDD:275368	8/19 (42%)
		C2H2 Zn finger	385..406	CDD:275370	6/20 (30%)
		C2H2 Zn finger	414..434	CDD:275368	9/19 (47%)
		zf-H2C2_2	427..451	CDD:290200	15/23 (65%)
		C2H2 Zn finger	442..490	CDD:275368	16/47 (34%)
		C2H2 Zn finger	470..487	CDD:275368	5/16 (31%)
		zf-H2C2_2	482..507	CDD:290200	11/24 (46%)
		C2H2 Zn finger	498..518	CDD:275368	6/19 (32%)
		zf-H2C2_2	510..534	CDD:290200	12/23 (52%)
		C2H2 Zn finger	526..546	CDD:275368	5/19 (26%)
		zf-H2C2_2	539..563	CDD:290200	12/23 (52%)
		C2H2 Zn finger	554..574	CDD:275368	7/19 (37%)
		C2H2 Zn finger	582..602	CDD:275368	4/19 (21%)
ZNF568	NP_940941.2	KRAB	48..102	CDD:214630	12/56 (21%)
		KRAB	48..87	CDD:279668	10/41 (24%)
		C2H2 Zn finger	224..244	CDD:275368	2/19 (11%)
		zf-H2C2_2	236..261	CDD:290200	1/24 (4%)
		COG5048	248..634	CDD:227381	109/352 (31%)
		C2H2 Zn finger	252..272	CDD:275368	3/19 (16%)
		zf-H2C2_2	264..289	CDD:290200	9/42 (21%)
		C2H2 Zn finger	280..300	CDD:275368	6/19 (32%)
		zf-H2C2_2	292..317	CDD:290200	3/24 (13%)
		C2H2 Zn finger	308..328	CDD:275368	2/19 (11%)
		zf-H2C2_2	320..345	CDD:290200	6/24 (25%)
		C2H2 Zn finger	336..356	CDD:275368	8/19 (42%)
		zf-H2C2_2	348..373	CDD:290200	8/24 (33%)
		C2H2 Zn finger	364..384	CDD:275368	6/20 (30%)
		zf-H2C2_2	380..401	CDD:290200	8/21 (38%)
		C2H2 Zn finger	392..412	CDD:275368	9/19 (47%)
		zf-H2C2_2	408..429	CDD:290200	15/20 (75%)
		C2H2 Zn finger	420..440	CDD:275368	8/19 (42%)
		zf-H2C2_2	432..457	CDD:290200	7/24 (29%)
		C2H2 Zn finger	448..468	CDD:275368	6/19 (32%)
		zf-H2C2_2	460..485	CDD:290200	11/24 (46%)
		C2H2 Zn finger	476..496	CDD:275368	6/19 (32%)
		zf-H2C2_2	488..513	CDD:290200	13/24 (54%)
		C2H2 Zn finger	504..524	CDD:275368	5/19 (26%)
		zf-H2C2_2	516..541	CDD:290200	12/24 (50%)
		C2H2 Zn finger	532..552	CDD:275368	7/19 (37%)
		zf-H2C2_2	544..569	CDD:290200	7/24 (29%)
		C2H2 Zn finger	560..580	CDD:275368	4/19 (21%)
		zf-H2C2_2	572..597	CDD:290200	2/9 (22%)
		C2H2 Zn finger	588..608	CDD:275368
		zf-H2C2_2	601..625	CDD:290200
		C2H2 Zn finger	616..636	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910