DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6654 and ZNF829

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001165450.1	Gene:	ZNF829 / 374899	HGNCID:	34032	Length:	513	Species:	Homo sapiens

Alignment Length:	527	Identity:	137/527 - (25%)
Similarity:	218/527 - (41%)	Gaps:	85/527 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 WEPDRCTASVQTDAVTTTDAEQNTSLIKSTISVDLDYEGEGEVFDYELPDEPVE---KTTSLILQ 171
            ||.:  ....:...:.|..|...|||....|.. ||..      ::.|..||:|   ...|.::.
Human    34 WEAE--AGGSRGQEIETILANMETSLRSGQIPT-LDSS------EHNLSPEPLELDRMPHSPLIS 89

  Fly   172 V---------QGNLKDEKEVVFTQTNVIYEGDDHELEQQIREC----NLAIFEGV--DNEAEIIT 221
            :         :..:.||.....::..|::.....:..|:..||    .:.:::.|  :|.:.:::
Human    90 IPHVWCHPEEEERMHDELLQAVSKGPVMFRDVSIDFSQEEWECLDADQMNLYKEVMLENFSNLVS 154

  Fly   222 VTAPQVTTRKSAAKLLTQQEN----DKHQTPVGSKEEARELEKEQVPQSAKRTSRRRGVVKQDVP 282
            |...  .::.:...||.|.:.    |:..|. |...:...:.:.::....||...:..:.::|:.
Human   155 VGLS--NSKPAVISLLEQGKEPWMVDRELTR-GLCSDLESMCETKILSLKKRHFSQVIITREDMS 216

  Fly   283 A-------TPPSDAEPSPKQHRLGTQRKLSAPRAGTVNGPSTTSGAATTPELKYHCDRCNAGFAV 340
            .       .||              |:.:|                   .|..:.|..|...|..
Human   217 TFIQPTFLIPP--------------QKTMS-------------------EEKPWECKICGKTFNQ 248

  Fly   341 EKSLMIHRR-QKGCINRNYKCNECEKVFVSPDHLAEHQASHGA---HNCPECGIRCDSKEALSKH 401
            ....:.|:| ..|  .::|:..|..|.|.....:..||..|..   :.|.|||.........|:|
Human   249 NSQFIQHQRIHFG--EKHYESKEYGKSFSRGSLVTRHQRIHTGKKPYECKECGKAFSCSSYFSQH 311

  Fly   402 MVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSFTQNANLRQHKLRHSETK 466
            . :.|......:|..|.|.|...|.|.||.||||||||:.|.:|||:||:::.|..|...|:..|
Human   312 Q-RIHTGEKPYECKECGKAFKYCSNLNDHQRIHTGEKPYECKVCGKAFTKSSQLFLHLRIHTGEK 375

  Fly   467 SFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTSCSLAKHKRKHTGERPYACDLCPM 531
            .::|:.|..:|...:.|..|.|.|||:||:||:.|...|.::.:|..|.|.|.||:.|.|:.|..
Human   376 PYECKECGKAFTQHSRLIQHQRMHTGEKPYECKQCGKAFNSASTLTNHHRIHAGEKLYECEECRK 440

  Fly   532 RFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQGERIYICPVCNEEFKSMPEMR 596
            .|...:.|..|:|.||.|:||.|..|.|.|.:..:...|||.|.||:.|.|..|.:.|.|    |
Human   441 AFIQSSELIQHQRIHTDEKPYECNECGKAFNKGSNLTRHQRIHTGEKPYDCKECGKAFGS----R 501

  Fly   597 SHLAGHE 603
            |.|..||
Human   502 SDLIRHE 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	6/23 (26%)
		COG5048	<357..570	CDD:227381	77/215 (36%)
		C2H2 Zn finger	360..380	CDD:275368	5/19 (26%)
		C2H2 Zn finger	385..406	CDD:275370	6/20 (30%)
		C2H2 Zn finger	414..434	CDD:275368	9/19 (47%)
		zf-H2C2_2	427..451	CDD:290200	16/23 (70%)
		C2H2 Zn finger	442..490	CDD:275368	16/47 (34%)
		C2H2 Zn finger	470..487	CDD:275368	4/16 (25%)
		zf-H2C2_2	482..507	CDD:290200	12/24 (50%)
		C2H2 Zn finger	498..518	CDD:275368	6/19 (32%)
		zf-H2C2_2	510..534	CDD:290200	9/23 (39%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		zf-H2C2_2	539..563	CDD:290200	12/23 (52%)
		C2H2 Zn finger	554..574	CDD:275368	7/19 (37%)
		C2H2 Zn finger	582..602	CDD:275368	7/19 (37%)
ZNF829	NP_001165450.1	KRAB	116..176	CDD:214630	10/61 (16%)
		KRAB	116..155	CDD:279668	6/38 (16%)
		COG5048	<149..425	CDD:227381	78/314 (25%)
		zf-C2H2	238..259	CDD:278523	5/20 (25%)
		C2H2 Zn finger	239..259	CDD:275368	5/19 (26%)
		C2H2 Zn finger	271..287	CDD:275368	4/15 (27%)
		zf-H2C2_2	282..304	CDD:290200	7/21 (33%)
		C2H2 Zn finger	295..315	CDD:275368	6/20 (30%)
		zf-H2C2_2	307..332	CDD:290200	7/25 (28%)
		C2H2 Zn finger	323..343	CDD:275368	9/19 (47%)
		zf-H2C2_2	335..359	CDD:290200	15/23 (65%)
		C2H2 Zn finger	351..371	CDD:275368	8/19 (42%)
		zf-H2C2_2	367..388	CDD:290200	6/20 (30%)
		C2H2 Zn finger	379..399	CDD:275368	6/19 (32%)
		zf-H2C2_2	392..416	CDD:290200	12/23 (52%)
		C2H2 Zn finger	407..427	CDD:275368	6/19 (32%)
		C2H2 Zn finger	435..455	CDD:275368	6/19 (32%)
		zf-H2C2_2	447..471	CDD:290200	11/23 (48%)
		C2H2 Zn finger	463..483	CDD:275368	7/19 (37%)
		zf-H2C2_2	475..498	CDD:290200	9/22 (41%)
		C2H2 Zn finger	491..511	CDD:275368	9/22 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910