DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6654 and CG10321

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001261124.1	Gene:	CG10321 / 37464	FlyBaseID:	FBgn0034643	Length:	855	Species:	Drosophila melanogaster

Alignment Length:	897	Identity:	158/897 - (17%)
Similarity:	268/897 - (29%)	Gaps:	358/897 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDVDKICLTCLSSTGPLLSIYDGGSGSCLADMIREFTKTKPRRNDNLPEKVCLSCLSEISNCYTF 65
            :::||||..|:|....:..::    ...:.:|:.:.|..:....:..|:|:|:.|:..:|..:.|
  Fly     7 LELDKICRLCISERKEMRPLF----SEKVPEMLMDCTSVRVEPTEGWPDKICVQCVHAVSRNHAF 67

  Fly    66 KIKCENSSRTLR----------------------------------------------------- 77
            |...|.|.:.||
  Fly    68 KTLVERSDKELREYIRGLTVALVMEEQQQQEAANAKQQLQLERKQQRQLQKQQKILEEQLQQQIV 132

  Fly    78 -----------------------------------------------QLLPNALPEEPDSKVSI- 94
                                                           ||:....|::|..:..|
  Fly   133 QQQQHQPPAKPKLKPLLRKGSRQQKQRHLEAAPAPQSVPQPAPQPQMQLMQEHAPQQPTMQQQIQ 197

  Fly    95 ---------------------------------------------------SCPVATTD------ 102
                                                               :.|.:||:
  Fly   198 QIHMPTLQPAPAQLLSAAGATTTMPQQILLPNGQLITTAQIVAPQLAQIISTAPQSTTNGQATAA 262

  Fly   103 --------------------------QAVQTTSWEPDRCTASVQTDAVTT----TDAEQNTSLIK 137
                                      |.:|.....|.|..|......|||    ||..|:.....
  Fly   263 QSQFLPQLLQTPNGQTLQIVQQPNGTQTLQLVQLVPQRSLAPTGVTTVTTTTNATDMGQHVGASL 327

  Fly   138 STISVDLDYEGEGEVFDYELPD--EPVEKTT-----SLIL---QVQGNLKDEKE---VVFTQTNV 189
            ....|.|..:| .||.|.||.|  |.::...     :::|   |.|..|||..|   |:..:...
  Fly   328 GDADVQLLEDG-CEVEDEELEDVYEQLDSKADHSFETIVLDDDQQQDFLKDHHEHHQVMINEDLT 391

  Fly   190 IYEGDDHE----LEQQIRECNLAIFEGVDNEAEIITVTAPQVTTRKSAAKLLTQQENDKHQTPVG 250
            ..|..|||    |:||      ...:.:::|.|.:.....|.|......:|   ::::....|.|
  Fly   392 QSESQDHEYFDDLDQQ------QAMDEIEDEEEQMKPEEDQDTFIIEEIQL---EDDEMLDDPDG 447

  Fly   251 SK--EEARELEKEQVPQSAKRTSRRRGVVKQDVPAT---PPS------------DAEPSPKQHRL 298
            .:  ::...:.:||.|..:       |.|..|:..:   ||.            |:|.|..|...
  Fly   448 EEIDQDCEYIGEEQDPHLS-------GDVDDDLEYSIMEPPDGETSVDIDQAFMDSEQSHHQQHQ 505

  Fly   299 GTQRKLSAPRA-----------GTVNGPS-TTSGAATTPELKYHCDRCN----AGFAVEKSLMIH 347
            ...:.:|...|           ..:.||: |.|.|:.||:   ...|.|    ||..:|
  Fly   506 EEMQSISLENAVVEFSQATTTTEALVGPTMTVSSASPTPK---RAKRSNHQIPAGVTLE------ 561

  Fly   348 RRQKGCINRNYKCNECEKVFVSPDHLAEHQASHGAHNCPECGIRCDSK--EALSKHMVQ------ 404
                          .|:                  |..|..|....||  .|.|:.:||
  Fly   562 --------------PCD------------------HQPPAAGSTTSSKLAAANSRQLVQTASVIA 594

  Fly   405 --GHKRNLRNQCNICQKVFTMLSTLRDHMRIHT---GEKPFVCNICGKSFTQNANLRQHKLRHSE 464
              |...|.....|:          :.:.:|.||   |...::|::|...|.|...|:.|...|:.
  Fly   595 AAGADDNYEIDANL----------VTEFIRQHTSPLGSGRYICHLCSTEFRQFKGLQNHMHSHTN 649

  Fly   465 TKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTSCSLAKHKRKHTGERPY-ACDL 528
            .....|:..|                      :|::||..|.....|..|.:.|..|... .|.:
  Fly   650 WIRANCKKQP----------------------QCQICLKSFKGPGMLRMHMKTHDAESSTPMCTI 692

  Fly   529 CPMRFTALNVLKNHRRTHTGERPYVCPF--CSKTFTQRGDCQMH-QRTHQG--ERIYICPVCNEE 588
            |...|.:..:|..||:||. :|.|.|..  |.|.|:...:.:.| :|.|..  :.::.|..|...
  Fly   693 CNRTFKSKAILYRHRQTHQ-QRAYCCGVANCRKNFSSAVNLKWHVERKHPEVVDPLFKCGECGSL 756

  Fly   589 FKSMPEMRSHLAGHEQHDKRLVHFTFLSNKENG-SGALEEELNEMTESALML 639
            :.::..::.|:...: |...:.    :|.:::. |||:....|..|:.:.|:
  Fly   757 YDNVDSLQLHVESTD-HSAEVQ----ISGQDDAFSGAVSIVSNGTTDMSNMM 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071	17/172 (10%)
		C2H2 Zn finger	331..354	CDD:275368	5/26 (19%)
		COG5048	<357..570	CDD:227381	48/228 (21%)
		C2H2 Zn finger	360..380	CDD:275368	1/19 (5%)
		C2H2 Zn finger	385..406	CDD:275370	8/30 (27%)
		C2H2 Zn finger	414..434	CDD:275368	2/19 (11%)
		zf-H2C2_2	427..451	CDD:290200	7/26 (27%)
		C2H2 Zn finger	442..490	CDD:275368	9/47 (19%)
		C2H2 Zn finger	470..487	CDD:275368	2/16 (13%)
		zf-H2C2_2	482..507	CDD:290200	4/24 (17%)
		C2H2 Zn finger	498..518	CDD:275368	6/19 (32%)
		zf-H2C2_2	510..534	CDD:290200	6/24 (25%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		zf-H2C2_2	539..563	CDD:290200	11/25 (44%)
		C2H2 Zn finger	554..574	CDD:275368	6/22 (27%)
		C2H2 Zn finger	582..602	CDD:275368	3/19 (16%)
CG10321	NP_001261124.1	zf-AD	12..80	CDD:214871	16/71 (23%)
		ASF1_hist_chap	<405..516	CDD:304562	22/126 (17%)
		C2H2 Zn finger	627..647	CDD:275368	6/19 (32%)
		C2H2 Zn finger	661..681	CDD:275368	6/19 (32%)
		C2H2 Zn finger	690..710	CDD:275368	6/19 (32%)
		C2H2 Zn finger	717..740	CDD:275368	6/22 (27%)
		C2H2 Zn finger	750..767	CDD:275368	2/16 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	0	0.000