DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and Zbtb48

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	XP_038966377.1	Gene:	Zbtb48 / 362668	RGDID:	1311581	Length:	739	Species:	Rattus norvegicus

Alignment Length:	709	Identity:	148/709 - (20%)
Similarity:	234/709 - (33%)	Gaps:	246/709 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 ALPEEPDSKVSISCPVATTDQAVQ-TTSWEPDRCTASVQTDAVTTTDAEQNTSLIKSTISVDLDY 146
            ||......:|.::.......:||: ..|::|.......|:.....:..:..:.|.:.|   |||
  Rat    86 ALTSGNRDQVLLAAKELRVPEAVELCQSFQPQTSAGQAQSGPGQVSSQDVKSHLKEPT---DLD- 146

  Fly   147 EGEGEVF-------------DYELP--DEPVEKTTSLILQVQGNLKDEKEVVFTQTNVIYEGDDH 196
              |.|||             |.|.|  ..|.:.:.:.:.   |.|   |:|:........|.:|.
  Rat   147 --EEEVFRTLSLASVDQEPRDGEQPQLSTPAQSSPAFLC---GKL---KQVLKPSPPADKESEDS 203

  Fly   197 ELEQQIRECNLAIFEGVDNEAEIITVTAPQVTTRKSAAKLLTQQENDKHQTPVGSKEEARELEKE 261
            :...:..|...|..:|..||.|::                 .|.|:|:.    |..:.|.|
  Rat   204 KEPPRPFEAEGAPLQGESNEWEVV-----------------VQVEDDRD----GDGDYASE---- 243

  Fly   262 QVPQSAKRTSRRRGVVKQDVPATPPSDAEPSPKQHRLGTQRKLSAPRAGTVNGPSTTSGAATTPE 326
              |::. .|.|:..|:::      |..|||:     ||.....:.|..|       ..|||...|
  Rat   244 --PETV-LTRRKSKVIRK------PCAAEPA-----LGAGSLTAEPTEG-------RKGAAVPVE 287

  Fly   327 LKYHCDRCNAGFAVEKSLMIHRRQKGCINRNYKCNECEKVFVSPDHLAEHQASHGAHNCPECGIR 391
                |..|:..|..:..|.:|.| |....:.::|.:|.|.:...::|.||:|
  Rat   288 ----CPTCHKKFLSKYYLKVHNR-KHTGEKPFECPKCGKCYFRKENLLEHEA------------- 334

  Fly   392 CDSKEALSKHMVQGHKRNLRNQ------CNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSFT 450
                            ||..|:      |::||:.|.....||.||..||||.|:.|:.|.:.|.
  Rat   335 ----------------RNCMNRSEQVFTCSVCQETFRRRMELRVHMVSHTGEMPYKCSSCSQQFM 383

  Fly   451 QNANLRQHKLR-HSETK--------------SFKCELCPH------------------------- 475
            |..:|:.|.:: |...|              .:..:.|||
  Rat   384 QKKDLQSHMIKLHGAPKPHAVSAKQGWGSCGPWTAQPCPHLDSLPLPVSPSCSAPLVPSASCLGR 448

  Fly   476 --------SFVTKAEL------------------------------TSHARTHTGDKPFECEVCL 502
                    |.|.|:.|                              .|.|..|:..:|.....|.
  Rat   449 SYSCTRLLSIVEKSSLCVKNVGTGPQAAMGCRCTSRPSTGMKGRMSVSSAAMHSPRRPTSTCTCA 513

  Fly   503 -------------------------------------ARFTTSCSLAKHKRKHTGERPYACDLCP 530
                                                 :..:.:.||.||.|.||||||::|:.|.
  Rat   514 HTQERSPSSATSVGRPSAPKVRQARPLLASGLRQVLSSTLSPTASLDKHNRTHTGERPFSCEFCE 578

  Fly   531 MRFTALNVLKNH-RRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQGERIYICPVCNEEFKSMPE 594
            .|||....|..| ...|...||:.|..|.|||......::|.|.|:|.|.:.|..|..:|.....
  Rat   579 QRFTEKGPLLRHVASRHQEGRPHFCQICGKTFKAVEQLRVHVRRHKGVRKFECTECGYKFTRQAH 643

  Fly   595 MRSHLAGHEQ----------------HDKRLVHFTFLSNKENGSGALEEELNEMTESAL 637
            :|.|:..|::                .|:::|........:...|:.|..:..:|:..|
  Rat   644 LRRHMEIHDRVENYNPRQRKLRNLIIDDEKMVVVALQPPADLEVGSAEVIVESLTQGGL 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	7/22 (32%)
		COG5048	<357..570	CDD:227381	69/334 (21%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
		C2H2 Zn finger	385..406	CDD:275370	0/20 (0%)
		C2H2 Zn finger	414..434	CDD:275368	8/19 (42%)
		zf-H2C2_2	427..451	CDD:290200	12/23 (52%)
		C2H2 Zn finger	442..490	CDD:275368	17/125 (14%)
		C2H2 Zn finger	470..487	CDD:275368	8/79 (10%)
		zf-H2C2_2	482..507	CDD:290200	6/91 (7%)
		C2H2 Zn finger	498..518	CDD:275368	6/56 (11%)
		zf-H2C2_2	510..534	CDD:290200	14/23 (61%)
		C2H2 Zn finger	526..546	CDD:275368	7/20 (35%)
		zf-H2C2_2	539..563	CDD:290200	10/24 (42%)
		C2H2 Zn finger	554..574	CDD:275368	7/19 (37%)
		C2H2 Zn finger	582..602	CDD:275368	5/19 (26%)
Zbtb48	XP_038966377.1	BTB_POZ_ZBTB48_TZAP_KR3	8..115	CDD:349541	6/28 (21%)
		C2H2 Zn finger	288..308	CDD:275368	6/20 (30%)
		zf-H2C2_2	300..323	CDD:404364	7/23 (30%)
		C2H2 Zn finger	316..367	CDD:275368	18/79 (23%)
		zf-C2H2	345..367	CDD:395048	8/21 (38%)
		zf-H2C2_2	359..382	CDD:404364	11/22 (50%)
		C2H2 Zn finger	375..396	CDD:275368	6/20 (30%)
		C2H2 Zn finger	574..595	CDD:275368	7/20 (35%)
		C2H2 Zn finger	603..623	CDD:275368	7/19 (37%)
		zf-H2C2_2	616..640	CDD:404364	8/23 (35%)
		zf-C2H2	629..651	CDD:395048	5/21 (24%)
		C2H2 Zn finger	631..651	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010