DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZBTB41

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_919290.2	Gene:	ZBTB41 / 360023	HGNCID:	24819	Length:	909	Species:	Homo sapiens

Alignment Length:	609	Identity:	154/609 - (25%)
Similarity:	244/609 - (40%)	Gaps:	114/609 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 PEKVCLSCLSEISN------C---YTFKIKCENS-SRTLRQLL---PNALP------EEPDSKVS 93
            ||:........:||      |   :.:|...||. ::|.|.||   .:.|.      ....||.:
Human   192 PEETLNELTGRLSNNHQCKFCSRHFCYKKSLENHLAKTHRSLLLGKKHGLKMLERSFSARRSKRN 256

  Fly    94 ISCPVATTDQAVQTTSWEPDRCTASVQTDAVTTTDAEQNTSLIKSTISVDLDYEGEG------EV 152
            ..|||...|                       |:|.||.:              |:|      |.
Human   257 RKCPVKFDD-----------------------TSDDEQES--------------GDGSDNLNQEN 284

  Fly   153 FDYELPD-----EPVEKTTSLILQVQGNLKDEKEVVFTQTNVIYEGDDHELEQQIRECNLAIFEG 212
            ||.|..|     :|..:..:...:::..:.||...:..|:    |.|.::.|:: .|..    :.
Human   285 FDKEKSDRNDSEDPGSEYNAEEDELEEEMSDEYSDIEEQS----EKDHNDAEEE-PEAG----DS 340

  Fly   213 VDNEAEIITVTAPQVTTRKSAAKLLTQQENDKHQTPVGSKEEARELEKEQVPQSAKRTSRRRGVV 277
            |.|..|.:|    .|..:.|..|:|...:.||....:|..|....:...:.|.... ...:|...
Human   341 VGNVHEGLT----PVVIQNSNKKILQCPKCDKTFDRIGKYESHTRVHTGEKPFECD-ICHQRYST 400

  Fly   278 KQDVPA---TPPSDAEPSPKQHRLGTQRKLSA---------PRAGTVNGPSTTSGAATTPELKYH 330
            |.::..   ...::.|...|:|:.....||.|         .|....|.....|...|..| .:.
Human   401 KSNLTVHRKKHSNETEFHKKEHKCPYCNKLHASKKTLAKHVKRFHPENAQEFISIKKTKSE-SWK 464

  Fly   331 CDRCNAGFA----VEKSLMIHRRQKGCINRNYKCNECEKVFVSPDHLAEHQASH--GAHNCPECG 389
            ||.|...|.    :|:.:::|.:.|     .:||..||:.|.|.....:||...  |...|..||
Human   465 CDICKKSFTRRPHLEEHMILHSQDK-----PFKCTYCEEHFKSRFARLKHQEKFHLGPFPCDICG 524

  Fly   390 IRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSFTQNAN 454
            .:.:....|.:|:...|....:..|.||.|.....:||::|:|||:||||.:|:|||:||...::
Human   525 RQFNDTGNLKRHIECTHGGKRKWTCFICGKSVRERTTLKEHLRIHSGEKPHLCSICGQSFRHGSS 589

  Fly   455 LRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTSCSLAKH-KRKH 518
            .|.|...|.:.|.::|:.|..:|:....||.|.:.|:|:|..:||.|...|.....|..| |..|
Human   590 YRLHLRVHHDDKRYECDECGKTFIRHDHLTKHKKIHSGEKAHQCEECGKCFGRRDHLTVHYKSVH 654

  Fly   519 TGERP--------YACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQ 575
            .||:.        :.||:|...|...:.|:.|.|||:||:||.|..|:::|..:.....|...|.
Human   655 LGEKVWQKYKATFHQCDVCKKIFKGKSSLEMHFRTHSGEKPYKCQICNQSFRIKKTLTKHLVIHS 719

  Fly   576 GERIYICPVCNEEFKSMPEMRSHL 599
            ..|.:.|..||..||...:::.|:
Human   720 DARPFNCQHCNATFKRKDKLKYHI 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071	10/40 (25%)
		C2H2 Zn finger	331..354	CDD:275368	7/26 (27%)
		COG5048	<357..570	CDD:227381	74/223 (33%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
		C2H2 Zn finger	385..406	CDD:275370	5/20 (25%)
		C2H2 Zn finger	414..434	CDD:275368	8/19 (42%)
		zf-H2C2_2	427..451	CDD:290200	15/23 (65%)
		C2H2 Zn finger	442..490	CDD:275368	16/47 (34%)
		C2H2 Zn finger	470..487	CDD:275368	5/16 (31%)
		zf-H2C2_2	482..507	CDD:290200	10/24 (42%)
		C2H2 Zn finger	498..518	CDD:275368	7/20 (35%)
		zf-H2C2_2	510..534	CDD:290200	9/32 (28%)
		C2H2 Zn finger	526..546	CDD:275368	7/19 (37%)
		zf-H2C2_2	539..563	CDD:290200	12/23 (52%)
		C2H2 Zn finger	554..574	CDD:275368	4/19 (21%)
		C2H2 Zn finger	582..602	CDD:275368	6/18 (33%)
ZBTB41	NP_919290.2	BTB_POZ_ZBTB41	66..179	CDD:349535
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	252..344		26/137 (19%)
		C2H2 Zn finger	363..383	CDD:275368	4/19 (21%)
		C2H2 Zn finger	391..411	CDD:275368	2/20 (10%)
		C2H2 Zn finger	424..442	CDD:275368	3/17 (18%)
		C2H2 Zn finger	465..485	CDD:275368	5/19 (26%)
		C2H2 Zn finger	493..510	CDD:275368	5/16 (31%)
		C2H2 Zn finger	520..541	CDD:275368	5/20 (25%)
		C2H2 Zn finger	549..569	CDD:275368	8/19 (42%)
		C2H2 Zn finger	577..597	CDD:275368	8/19 (42%)
		zf-C2H2	603..625	CDD:395048	6/21 (29%)
		C2H2 Zn finger	605..625	CDD:275368	6/19 (32%)
		C2H2 Zn finger	633..651	CDD:275368	6/17 (35%)
		C2H2 Zn finger	670..687	CDD:275368	5/16 (31%)
		C2H2 Zn finger	698..718	CDD:275368	4/19 (21%)
		C2H2 Zn finger	726..743	CDD:275368	5/16 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910