DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6654 and hic2

DIOPT Version :9

Sequence 1:NP_650429.1 Gene:CG6654 / 41831 FlyBaseID:FBgn0038301 Length:639 Species:Drosophila melanogaster
Sequence 2:NP_878289.2 Gene:hic2 / 359828 ZFINID:ZDB-GENE-030619-1 Length:560 Species:Danio rerio


Alignment Length:457 Identity:118/457 - (25%)
Similarity:171/457 - (37%) Gaps:107/457 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   115 CTASVQTDAVTTTDAEQNTSLIKSTISVDLDYEGEG------EVFDYELPDEPVEKTTSLILQVQ 173
            ||.|......|:.:. .|.|.....:.:||..:...      ||....:|.|..:..:    :..
Zfish   184 CTTSNSLSPSTSKNG-SNGSCGMQELGLDLSKKSPSGSTATEEVSPSSIPQESPQSAS----EST 243

  Fly   174 GNLKDEKEVVFTQTNVIYEGDDHELEQQIRECNLAIFEGVDNEAEIITVTAPQVTTRKSAAKLLT 238
            .|.....|...||.  :..|:..||  .:.||         .|::    ..|.|...||:.::..
Zfish   244 ANSASFDENPNTQN--LTAGEPMEL--GVGEC---------EESQ----PPPDVDQHKSSRQVTR 291

  Fly   239 QQENDKHQTPVGSKEEARELEKEQVPQSAKRTSRRRGVVKQDVPATPPSDAEPS--PKQHRLGTQ 301
            |:...|.:   |.|.|  ::|:..:|..   .|:|..|..:.:||....::|.|  .|....|.:
Zfish   292 QRRQPKSE---GKKGE--DMERVTLPNG---VSKRLKVAGERLPAGGNGNSEVSFQCKDEEEGLE 348

  Fly   302 RKLSAPRAGTVNGPSTTSGAATTPELKYHCDRCNAGFAVEKSLMIHRRQKG---CINRN-YKCNE 362
               :.......:|.|...|...:....|                   ||:|   .:..| |.|..
Zfish   349 ---NGQEQSEESGQSENEGGRNSANYVY-------------------RQEGFEPALGDNLYVCIP 391

  Fly   363 CEKVFVSPDHLAEHQASHGAHNCPECGIRCDSK-----------EALSKHMVQGHKRNLRN-QCN 415
            |.|.|.|.:.|..|..:|...   |..|:.:..           |.||..:.|.|....|. .|:
Zfish   392 CGKGFPSSEELNAHVETHTEE---ELYIKEEDNDSYPKEDEVEAEDLSSQITQVHGTETRRFSCS 453

  Fly   416 ICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTK 480
            :|.|.:...:|||.|.:.|...:||.||||||.|||                            :
Zfish   454 VCNKSYKDPATLRQHEKTHWLTRPFPCNICGKMFTQ----------------------------R 490

  Fly   481 AELTSHARTHTGDKPFECEVCLARFTTSCSLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRT 545
            ..:|.|.|:|.|.|||.||.|..|||....|.:|.|.|:||:||.|.||..:||....|.:|.|.
Zfish   491 GTMTRHMRSHLGLKPFACEECGMRFTRQYRLTEHMRVHSGEKPYECQLCGGKFTQQRNLISHLRM 555

  Fly   546 HT 547
            ||
Zfish   556 HT 557

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6654NP_650429.1 zf-AD 6..79 CDD:285071
C2H2 Zn finger 331..354 CDD:275368 3/25 (12%)
COG5048 <357..570 CDD:227381 69/204 (34%)
C2H2 Zn finger 360..380 CDD:275368 7/19 (37%)
C2H2 Zn finger 385..406 CDD:275370 6/31 (19%)
C2H2 Zn finger 414..434 CDD:275368 7/19 (37%)
zf-H2C2_2 427..451 CDD:290200 13/23 (57%)
C2H2 Zn finger 442..490 CDD:275368 12/47 (26%)
C2H2 Zn finger 470..487 CDD:275368 1/16 (6%)
zf-H2C2_2 482..507 CDD:290200 13/24 (54%)
C2H2 Zn finger 498..518 CDD:275368 9/19 (47%)
zf-H2C2_2 510..534 CDD:290200 11/23 (48%)
C2H2 Zn finger 526..546 CDD:275368 8/19 (42%)
zf-H2C2_2 539..563 CDD:290200 5/9 (56%)
C2H2 Zn finger 554..574 CDD:275368
C2H2 Zn finger 582..602 CDD:275368
hic2NP_878289.2 BTB 18..118 CDD:279045
BTB 25..120 CDD:197585
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 122..163
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 183..367 45/215 (21%)
C2H2 Zn finger 389..409 CDD:275368 7/19 (37%)
zf-C2H2 450..472 CDD:278523 7/21 (33%)
C2H2 Zn finger 452..472 CDD:275368 7/19 (37%)
zf-C2H2 478..500 CDD:278523 13/49 (27%)
C2H2 Zn finger 480..500 CDD:275368 12/47 (26%)
zf-H2C2_2 493..517 CDD:290200 13/23 (57%)
C2H2 Zn finger 508..528 CDD:275368 9/19 (47%)
zf-H2C2_2 521..545 CDD:290200 12/23 (52%)
C2H2 Zn finger 536..556 CDD:275368 8/19 (42%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
00.000

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