DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6654 and ZNF445

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_852466.1	Gene:	ZNF445 / 353274	HGNCID:	21018	Length:	1031	Species:	Homo sapiens

Alignment Length:	653	Identity:	156/653 - (23%)
Similarity:	230/653 - (35%)	Gaps:	173/653 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 SRTLRQLLPNALPEEPDS-KVSISCPVATTDQAV------QTTSWEPDRCTASVQTDAVTTTDAE 130
            |:|.:.:|.....||.:: .||..||..:..:.:      |..|.:.|:|...:|   |.....|
Human   316 SKTNKFILNQEPLEEAETLAVSSGCPATSVSEGIGLRESFQQKSRQKDQCENPIQ---VRVKKEE 377

  Fly   131 QN-------TSLIKSTISVDLDY--------------EGEGEVF-------DYELPDEPVEKTT- 166
            .|       .|.:..:.|:||.:              .|.|:.|       ||:...:.:....
Human   378 TNFSHRTGKDSEVSGSNSLDLKHVTYLRVSGRKESLKHGCGKHFRMSSHHYDYKKYGKGLRHMIG 442

  Fly   167 --SLILQVQGNLKDEKEVVFTQTNVIYEGDDHELEQQIRECNLAIFEGVDNEAEIITVTAPQVTT 229
              ||..::...||..|:.|.        |.|..|....:........||..:......|....:.
Human   443 GFSLHQRIHSGLKGNKKDVC--------GKDFSLSSHHQRGQSLHTVGVSFKCSDCGRTFSHSSH 499

  Fly   230 RKSAAKLLTQQE-------------------NDKHQTPVGSKEEAREL-EKEQVPQSAKRTSRRR 274
            .....:|.||::                   ::|..|  |.|....:| ||.....||.|..|..
Human   500 LAYHQRLHTQEKAFKCRVCGKAFRWSSNCARHEKIHT--GVKPYKCDLCEKAFRRLSAYRLHRET 562

  Fly   275 GVVKQDVPATPPSDA--EPSPKQHRLGTQRKLSAPRAGTVNGPSTTSGAATTPELKYHCDRCNAG 337
            ...|:.:.......|  ..|...|.||.|                 ||     |..:.|.:|...
Human   563 HAKKKFLELNQYRAALTYSSGFDHHLGDQ-----------------SG-----EKLFDCSQCRKS 605

  Fly   338 FAVEKSLMIHRR---QKGCINRNYKCNECEKVFVSPDHLAEHQASH-------------GAHNCP 386
            |..:..::.|:|   |:    :.|||.:|.|.|....:...|...|             |....|
Human   606 FHCKSYVLEHQRIHTQE----KPYKCTKCRKTFRWRSNFTRHMRLHEEEKFYKQDECREGFRQSP 666

  Fly   387 ECGIRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSFTQ 451
            :|. :.....|:.|..:          |..|.|.||...||.||.||||||||:.|:.|||.|..
Human   667 DCS-QPQGAPAVEKTFL----------CQQCGKTFTRKKTLVDHQRIHTGEKPYQCSDCGKDFAY 720

  Fly   452 NANLRQHKLR-------------------------HSETKSFKCELCPHSFVTKAELTSHARTHT 491
            .:....||.:                         ||:.:.:||..|..:|...:.|..|.|.||
Human   721 RSAFIVHKKKHAMKRKPEGGPSFSQDTVFQVPQSSHSKEEPYKCSQCGKAFRNHSFLLIHQRVHT 785

  Fly   492 GDKPFECEVCLARFTTSCSLAKHKRKH----------------------TGERPYACDLCPMRFT 534
            |:||::|..|...|..|.:|.:|:|.|                      |||:.:.|..|...||
Human   786 GEKPYKCRECGKAFRWSSNLYRHQRIHSLQKQYDCHESEKTPNVEPKILTGEKRFWCQECGKTFT 850

  Fly   535 ALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQGERIYICPVCNEEFKSMPEMRSHL 599
            ....|.:|:..|:||:.|.|..|.|::.:......|||.|..||.:.|..|.:||.....:.||.
Human   851 RKRTLLDHKGIHSGEKRYKCNLCGKSYDRNYRLVNHQRIHSTERPFKCQWCGKEFIGRHTLSSHQ 915

  Fly   600 AGH 602
            ..|
Human   916 RKH 918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071	2/5 (40%)
		C2H2 Zn finger	331..354	CDD:275368	6/25 (24%)
		COG5048	<357..570	CDD:227381	75/272 (28%)
		C2H2 Zn finger	360..380	CDD:275368	5/19 (26%)
		C2H2 Zn finger	385..406	CDD:275370	4/20 (20%)
		C2H2 Zn finger	414..434	CDD:275368	10/19 (53%)
		zf-H2C2_2	427..451	CDD:290200	16/23 (70%)
		C2H2 Zn finger	442..490	CDD:275368	16/72 (22%)
		C2H2 Zn finger	470..487	CDD:275368	4/16 (25%)
		zf-H2C2_2	482..507	CDD:290200	11/24 (46%)
		C2H2 Zn finger	498..518	CDD:275368	7/19 (37%)
		zf-H2C2_2	510..534	CDD:290200	9/45 (20%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		zf-H2C2_2	539..563	CDD:290200	9/23 (39%)
		C2H2 Zn finger	554..574	CDD:275368	6/19 (32%)
		C2H2 Zn finger	582..602	CDD:275368	6/19 (32%)
ZNF445	NP_852466.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43
		SCAN	51..155	CDD:128708
		KRAB	234..292	CDD:214630
		C2H2 Zn finger	415..451	CDD:275368	7/35 (20%)
		COG5048	<457..643	CDD:227381	44/221 (20%)
		C2H2 Zn finger	460..479	CDD:275368	4/26 (15%)
		C2H2 Zn finger	487..507	CDD:275368	1/19 (5%)
		C2H2 Zn finger	515..535	CDD:275368	1/19 (5%)
		C2H2 Zn finger	543..563	CDD:275368	7/19 (37%)
		COG5048	595..1031	CDD:227381	94/339 (28%)
		C2H2 Zn finger	599..619	CDD:275368	5/19 (26%)
		C2H2 Zn finger	627..647	CDD:275368	5/19 (26%)
		C2H2 Zn finger	683..703	CDD:275368	10/19 (53%)
		C2H2 Zn finger	711..731	CDD:275368	7/19 (37%)
		C2H2 Zn finger	764..784	CDD:275368	6/19 (32%)
		C2H2 Zn finger	792..812	CDD:275368	7/19 (37%)
		C2H2 Zn finger	842..862	CDD:275368	6/19 (32%)
		C2H2 Zn finger	870..890	CDD:275368	6/19 (32%)
		C2H2 Zn finger	898..918	CDD:275368	6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..939		3/8 (38%)
		C2H2 Zn finger	953..972	CDD:275368
		C2H2 Zn finger	980..1000	CDD:275368
		C2H2 Zn finger	1008..1028	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910