DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZNF879

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001129588.1	Gene:	ZNF879 / 345462	HGNCID:	37273	Length:	563	Species:	Homo sapiens

Alignment Length:	346	Identity:	116/346 - (33%)
Similarity:	160/346 - (46%)	Gaps:	41/346 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   294 KQHRLGTQRKL----SAPRAGTVNGPSTTSGAATTPELKYHCDRCNAGFAVEKSLMIHRRQ---- 350
            |..|:.|..||    ...:|.:.:...|......|.|..|.|..|...|:...||:.|:|.
Human   221 KHQRIHTGEKLYKCKECRKAFSQSSSLTQHLRVHTGEKPYICSECGKAFSFTTSLIGHQRMHTGE 285

  Fly   351 ------------KGCINRN-----------YKCNECEKVFVSPDHLAEHQASHGA---HNCPECG 389
                        ||..:.|           ||||||.:.|.....|.:|...|..   :.|.:||
Human   286 RPYKCKECGKTFKGSSSLNNHQRIHTGEKPYKCNECGRAFSQCSSLIQHHRIHTGEKPYECTQCG 350

  Fly   390 IRCDSKEALSKHMVQGHKRNLRNQ---CNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSFTQ 451
            ....|...||:|    |:.:...:   ||.|.|||:..|.|..|.||||||||:.|..|||:|:|
Human   351 KAFTSISRLSRH----HRIHTGEKPFHCNECGKVFSYHSALIIHQRIHTGEKPYACKECGKAFSQ 411

  Fly   452 NANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTSCSLAKHKR 516
            ::.|.||:..|:..|.:||..|..:|...:.|..|.|.|||:||:.|:.|...|::...:..|::
Human   412 SSALIQHQRIHTGEKPYKCNECGKAFSWISRLNIHHRIHTGEKPYNCKECGKAFSSHSGVNTHRK 476

  Fly   517 KHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQGERIYI 581
            .||||:||.|:.|...|...:.|..|:|.||||:||.|..|.|.|.|......|.|.|.||:.|.
Human   477 IHTGEKPYKCNDCEKAFNQSSALIQHQRIHTGEKPYNCKVCGKAFRQSSSLMTHMRIHTGEKPYK 541

  Fly   582 CPVCNEEFKSMPEMRSHLAGH 602
            |..|.:.|.....:.:|...|
Human   542 CKECGKAFSQSSSLTNHQRTH 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	9/38 (24%)
		COG5048	<357..570	CDD:227381	86/229 (38%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
		C2H2 Zn finger	385..406	CDD:275370	7/20 (35%)
		C2H2 Zn finger	414..434	CDD:275368	10/19 (53%)
		zf-H2C2_2	427..451	CDD:290200	15/23 (65%)
		C2H2 Zn finger	442..490	CDD:275368	18/47 (38%)
		C2H2 Zn finger	470..487	CDD:275368	4/16 (25%)
		zf-H2C2_2	482..507	CDD:290200	11/24 (46%)
		C2H2 Zn finger	498..518	CDD:275368	4/19 (21%)
		zf-H2C2_2	510..534	CDD:290200	9/23 (39%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		zf-H2C2_2	539..563	CDD:290200	13/23 (57%)
		C2H2 Zn finger	554..574	CDD:275368	7/19 (37%)
		C2H2 Zn finger	582..602	CDD:275368	4/19 (21%)
ZNF879	NP_001129588.1	KRAB	14..74	CDD:214630
		COG5048	202..558	CDD:227381	114/340 (34%)
		C2H2 Zn finger	206..226	CDD:275368	2/4 (50%)
		C2H2 Zn finger	234..254	CDD:275368	2/19 (11%)
		C2H2 Zn finger	262..282	CDD:275368	7/19 (37%)
		C2H2 Zn finger	290..310	CDD:275368	3/19 (16%)
		C2H2 Zn finger	318..338	CDD:275368	7/19 (37%)
		C2H2 Zn finger	346..366	CDD:275368	8/23 (35%)
		C2H2 Zn finger	374..394	CDD:275368	10/19 (53%)
		C2H2 Zn finger	402..422	CDD:275368	9/19 (47%)
		C2H2 Zn finger	430..450	CDD:275368	6/19 (32%)
		C2H2 Zn finger	458..478	CDD:275368	4/19 (21%)
		C2H2 Zn finger	486..506	CDD:275368	6/19 (32%)
		C2H2 Zn finger	514..534	CDD:275368	7/19 (37%)
		C2H2 Zn finger	542..562	CDD:275368	4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910