DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6654 and ZNF677

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001304927.1	Gene:	ZNF677 / 342926	HGNCID:	28730	Length:	584	Species:	Homo sapiens

Alignment Length:	506	Identity:	147/506 - (29%)
Similarity:	210/506 - (41%)	Gaps:	94/506 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 DAEQNTSLI----KSTISVDLDYEGEGEVFDYELPDEPVEKTTSLILQVQGNLKDEKEVVFTQTN 188
            |.:.|.|.|    |.::|:      ......|.:.|:|..:.   :|:::.|::
Human   133 DQQHNKSSIHFSLKQSVSI------RDSAHQYFIHDKPFIRN---LLKLKNNIR----------- 177

  Fly   189 VIYEGDDHELEQQIRECNLAIFE---GVDNEAEIITVTAPQVTTRKSAAKLLTQQENDKHQTPVG 250
              |.|:.:          :..||   |:..:|::              |:|...|..:|
Human   178 --YAGNKY----------VKCFENKIGLSLQAQL--------------AELQRFQTGEK------ 210

  Fly   251 SKEEARELEKEQVPQSAKRTSRRRGVVKQDVPATPPSDAEPSPKQHRLGTQRKLSAPRAGTVNGP 315
             ..|...:||              .:....|...||.......|..::     |..|..
Human   211 -MYECNPVEK--------------SINSSSVSPLPPCVKNICNKYRKI-----LKYPLL------ 249

  Fly   316 STTSGAATTPELKYHCDRCNAGFAVEKSLMIHRR-QKGCINRNYKCNECEKVFVSPDHLAEHQAS 379
            .|..|.....|..|.|:.|...|:...:|..|:| ..|  .|.||||||.|.|....:|..||..
Human   250 HTQYGRTHIREKSYKCNDCGKAFSKSSNLTNHQRIHSG--QRPYKCNECGKAFNQCSNLTRHQRV 312

  Fly   380 HGA---HNCPECGIRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFV 441
            |..   :.|..||..|.....|:.|. :.|......:||.|.|.|...|.|..|.||||||||:.
Human   313 HTGEKPYQCNICGKVCSQNSNLASHQ-RMHTGEKPYKCNECGKAFIQRSHLWGHERIHTGEKPYK 376

  Fly   442 CNICGKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFT 506
            ||.|.|:|.:.::|.|||..|:..|.:.|..|..:|...:.||.|...|.|:||.:|.||...|.
Human   377 CNECDKAFAERSSLTQHKRIHTGEKPYICNECGKAFKQCSHLTRHQNIHPGEKPHKCNVCGRAFI 441

  Fly   507 TSCSLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQ 571
            .|.||.:|:|.||||:||.|:.|...|...:.|..|:||||||:||.|..|.|.||:|.:...|:
Human   442 QSSSLVEHQRIHTGEKPYKCNKCDKAFIKRSHLWGHQRTHTGEKPYKCTECGKAFTERSNLTQHK 506

  Fly   572 RTHQGERIYICPVCNEEFKSMPEMRSHLAGH--EQHDKRLVHFTFLSNKEN 620
            :.|.||:.|.|..|.:.|.....:..|...|  ::|.|..:|...|....|
Human   507 KIHTGEKPYKCTECGKAFTQFANLTRHQKIHIEKKHCKHNIHGNALFQSSN 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	7/23 (30%)
		COG5048	<357..570	CDD:227381	90/215 (42%)
		C2H2 Zn finger	360..380	CDD:275368	9/19 (47%)
		C2H2 Zn finger	385..406	CDD:275370	6/20 (30%)
		C2H2 Zn finger	414..434	CDD:275368	9/19 (47%)
		zf-H2C2_2	427..451	CDD:290200	15/23 (65%)
		C2H2 Zn finger	442..490	CDD:275368	17/47 (36%)
		C2H2 Zn finger	470..487	CDD:275368	5/16 (31%)
		zf-H2C2_2	482..507	CDD:290200	11/24 (46%)
		C2H2 Zn finger	498..518	CDD:275368	9/19 (47%)
		zf-H2C2_2	510..534	CDD:290200	12/23 (52%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		zf-H2C2_2	539..563	CDD:290200	14/23 (61%)
		C2H2 Zn finger	554..574	CDD:275368	7/19 (37%)
		C2H2 Zn finger	582..602	CDD:275368	4/19 (21%)
ZNF677	NP_001304927.1	KRAB	9..59	CDD:214630
		COG5048	194..540	CDD:227381	126/394 (32%)
		C2H2 Zn finger	265..285	CDD:275368	6/19 (32%)
		C2H2 Zn finger	293..313	CDD:275368	9/19 (47%)
		C2H2 Zn finger	321..341	CDD:275368	6/20 (30%)
		C2H2 Zn finger	349..369	CDD:275368	9/19 (47%)
		C2H2 Zn finger	377..397	CDD:275368	9/19 (47%)
		C2H2 Zn finger	405..425	CDD:275368	6/19 (32%)
		C2H2 Zn finger	433..453	CDD:275368	9/19 (47%)
		C2H2 Zn finger	461..481	CDD:275368	6/19 (32%)
		C2H2 Zn finger	489..509	CDD:275368	7/19 (37%)
		C2H2 Zn finger	517..537	CDD:275368	4/19 (21%)
		C2H2 Zn finger	545..563	CDD:275368	3/13 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910