DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZNF850

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001180481.1	Gene:	ZNF850 / 342892	HGNCID:	27994	Length:	1090	Species:	Homo sapiens

Alignment Length:	390	Identity:	130/390 - (33%)
Similarity:	177/390 - (45%)	Gaps:	39/390 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 LLTQQENDKHQTPVGSKEEARELEKEQVPQSAKRTSRRRGVVKQDV-PATPPSDAEPSPK----- 294
            |:..|:|...:.|...||..:..           ||....:..|.: ....|.|.:...|
Human   716 LIQHQQNHTDEKPYDGKECGKSF-----------TSHSTLIQHQQIHTGEKPYDCKECGKSFTSH 769

  Fly   295 ----QH-RLGTQRKLSAPRAGTVNGPSTTSGAAT-------TPELKYHCDRCNAGFAVEKSLMIH 347
                || ::.|..||...:.   .|.|.||.:..       |.|..|||..|...|.:..:|:.|
Human   770 STLIQHQQIHTGEKLYDCKE---CGKSFTSHSTLIQHQPLHTGEKPYHCKECGKSFTLRSALIQH 831

  Fly   348 RR-QKGCINRNYKCNECEKVFVSPDHLAEHQASHGA---HNCPECGIRCDSKEALSKHMVQGHKR 408
            |. ..|  .:.|.|.||.|.|.|...|.|||..|..   ::|.|||.....:.|:.:|. :.|..
Human   832 RPVHTG--EKRYSCKECGKSFTSRSTLIEHQRIHTGEKPYHCKECGKSFAFRSAIIQHR-RIHTG 893

  Fly   409 NLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSFTQNANLRQHKLRHSETKSFKCELC 473
            .....|..|.|.|...|.|..|.||||||||:.|:.|||:|.:.:.|.:|...|:..|.::|:.|
Human   894 EKPYDCKECGKAFRRRSKLTQHQRIHTGEKPYRCHECGKAFVRFSGLTKHHSIHTGEKPYECKTC 958

  Fly   474 PHSFVTKAELTSHARTHTGDKPFECEVCLARFTTSCSLAKHKRKHTGERPYACDLCPMRFTALNV 538
            ..||..:..||.|.|.||||:|:||:.|...||....|.:|:|.||||:||.|..|...|...:.
Human   959 GKSFRQRTHLTLHQRIHTGDRPYECKECGKSFTCGSELIRHQRTHTGEKPYDCKECGKAFRCPSQ 1023

  Fly   539 LKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQGERIYICPVCNEEFKSMPEMRSHLAGHE 603
            |..|:|.||||:.|.||.|.|.|........||..|.||:.|.|..|.:.||.:.::..|...|:
Human  1024 LSQHKRIHTGEKTYQCPECGKAFFYASGLSRHQSVHTGEKPYECKTCGKAFKQLTQLTRHQRIHD 1088

Fly 604 603
Human 1089 1088

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	7/23 (30%)
		COG5048	<357..570	CDD:227381	86/215 (40%)
		C2H2 Zn finger	360..380	CDD:275368	10/19 (53%)
		C2H2 Zn finger	385..406	CDD:275370	6/20 (30%)
		C2H2 Zn finger	414..434	CDD:275368	8/19 (42%)
		zf-H2C2_2	427..451	CDD:290200	15/23 (65%)
		C2H2 Zn finger	442..490	CDD:275368	17/47 (36%)
		C2H2 Zn finger	470..487	CDD:275368	6/16 (38%)
		zf-H2C2_2	482..507	CDD:290200	13/24 (54%)
		C2H2 Zn finger	498..518	CDD:275368	7/19 (37%)
		zf-H2C2_2	510..534	CDD:290200	11/23 (48%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		zf-H2C2_2	539..563	CDD:290200	13/23 (57%)
		C2H2 Zn finger	554..574	CDD:275368	7/19 (37%)
		C2H2 Zn finger	582..602	CDD:275368	5/19 (26%)
ZNF850	NP_001180481.1	KRAB	7..67	CDD:214630
		KRAB	7..46	CDD:279668
		C2H2 Zn finger	199..219	CDD:275368
		C2H2 Zn finger	227..244	CDD:275368
		COG5048	243..659	CDD:227381
		C2H2 Zn finger	255..275	CDD:275368
		C2H2 Zn finger	283..303	CDD:275368
		zf-H2C2_2	296..319	CDD:290200
		C2H2 Zn finger	311..331	CDD:275368
		zf-H2C2_2	324..348	CDD:290200
		C2H2 Zn finger	339..359	CDD:275368
		zf-H2C2_2	351..375	CDD:290200
		C2H2 Zn finger	367..387	CDD:275368
		zf-H2C2_2	379..403	CDD:290200
		C2H2 Zn finger	395..415	CDD:275368
		C2H2 Zn finger	423..443	CDD:275368
		zf-H2C2_2	436..460	CDD:290200
		C2H2 Zn finger	451..471	CDD:275368
		zf-H2C2_2	463..487	CDD:290200
		C2H2 Zn finger	479..499	CDD:275368
		zf-H2C2_2	493..516	CDD:290200
		C2H2 Zn finger	507..527	CDD:275368
		zf-H2C2_2	519..543	CDD:290200
		COG5048	531..947	CDD:227381	73/247 (30%)
		C2H2 Zn finger	535..555	CDD:275368
		C2H2 Zn finger	563..583	CDD:275368
		zf-H2C2_2	575..599	CDD:290200
		C2H2 Zn finger	591..611	CDD:275368
		C2H2 Zn finger	619..639	CDD:275368
		zf-H2C2_2	632..656	CDD:290200
		C2H2 Zn finger	647..667	CDD:275368
		zf-H2C2_2	660..684	CDD:290200
		C2H2 Zn finger	675..695	CDD:275368
		zf-H2C2_2	687..711	CDD:290200
		C2H2 Zn finger	703..723	CDD:275368	2/6 (33%)
		C2H2 Zn finger	732..751	CDD:275368	5/29 (17%)
		C2H2 Zn finger	759..779	CDD:275368	3/19 (16%)
		C2H2 Zn finger	787..807	CDD:275368	4/22 (18%)
		C2H2 Zn finger	815..835	CDD:275368	6/19 (32%)
		C2H2 Zn finger	843..863	CDD:275368	10/19 (53%)
		zf-H2C2_2	856..879	CDD:290200	9/22 (41%)
		C2H2 Zn finger	871..891	CDD:275368	6/20 (30%)
		C2H2 Zn finger	899..919	CDD:275368	8/19 (42%)
		zf-H2C2_2	912..936	CDD:290200	15/23 (65%)
		C2H2 Zn finger	927..947	CDD:275368	7/19 (37%)
		C2H2 Zn finger	955..975	CDD:275368	8/19 (42%)
		zf-H2C2_2	967..992	CDD:290200	13/24 (54%)
		C2H2 Zn finger	983..1003	CDD:275368	7/19 (37%)
		zf-H2C2_2	995..1020	CDD:290200	12/24 (50%)
		C2H2 Zn finger	1011..1031	CDD:275368	6/19 (32%)
		zf-H2C2_2	1024..1046	CDD:290200	12/21 (57%)
		C2H2 Zn finger	1039..1059	CDD:275368	7/19 (37%)
		zf-H2C2_2	1052..1076	CDD:290200	9/23 (39%)
		C2H2 Zn finger	1067..1087	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910