DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZNF517

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001371833.1	Gene:	ZNF517 / 340385	HGNCID:	27984	Length:	492	Species:	Homo sapiens

Alignment Length:	445	Identity:	120/445 - (26%)
Similarity:	163/445 - (36%)	Gaps:	82/445 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   207 LAIFEGVDNEAEIITVTAPQVTTRKSAAKLLTQQENDKHQTPVGSKEEARELEKEQVPQSAKRTS 271
            :::.|..:....:|...|.|...:   |.|.|.           |:.||..:| ..:.:...|.:
Human    63 ISLLEQGEEPGALILQVAEQSVAK---ASLCTD-----------SRMEAGIME-SPLQRKLSRQA 112

  Fly   272 RRRGVVKQDVPATPPSDAEPSPKQHRLGTQRKLSAPRAGTVNGPSTTSGAATTPELKYHCD---- 332
            ...|.|...:|...|....|:| .|..|              ||...|...|.|..:.|..
Human   113 GLPGTVWGCLPWGHPVGGHPAP-PHPHG--------------GPEDGSDKPTHPRAREHSASPRV 162

  Fly   333 ----------------RCNAGFAVEKSLMIHRRQ---KGCINRNYKCNECEKVFVSPDHLAEHQA 378
                            ||..|.|...:.::.|.|   .|.  :.::|.||.|.|.....|..||.
Human   163 LQEDLGRPVGSSAPRYRCVCGKAFRYNSLLLRHQIIHTGA--KPFQCTECGKAFKQSSILLRHQL 225

  Fly   379 SHGAH---NCPECGIRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPF 440
            .|...   .|.|||........|:.|. :.|.|.....|..|.|.|:..|.|..|.:.|||||||
Human   226 IHTEEKPFQCGECGKAFRQSTQLAAHH-RVHTRERPYACGECGKAFSRSSRLLQHQKFHTGEKPF 289

  Fly   441 VCNICGKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTH--------------- 490
            .|..|||:|.:...|.:|...||..:.::|..|...|:..:.|..|.|.|
Human   290 ACTECGKAFCRRFTLNEHGRIHSGERPYRCLRCGQRFIRGSSLLKHHRLHAQEGAQDGGVGQGAL 354

  Fly   491 --------TGDKPFECEVCLARFTTSCSLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHT 547
                    .||.|.||.||...|..:..|..|.|.||||:|:.|..|...|...:.|..|::.||
Human   355 LGAAQRPQAGDPPHECPVCGRPFRHNSLLLLHLRLHTGEKPFECAECGKAFGRKSNLTLHQKIHT 419

  Fly   548 GERPYVCPFCSKTFTQRGDCQMHQRTHQGERIYICPVCNEEFKSMPEMRSHLAGH 602
            .|:|:.|..|.|.|.:......|.|.|.|||.|.|..|......:..:..|...|
Human   420 KEKPFACTECGKAFRRSYTLNEHYRLHSGERPYRCRACGRACSRLSTLIQHQKVH 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	7/45 (16%)
		COG5048	<357..570	CDD:227381	76/238 (32%)
		C2H2 Zn finger	360..380	CDD:275368	8/19 (42%)
		C2H2 Zn finger	385..406	CDD:275370	6/20 (30%)
		C2H2 Zn finger	414..434	CDD:275368	7/19 (37%)
		zf-H2C2_2	427..451	CDD:290200	14/23 (61%)
		C2H2 Zn finger	442..490	CDD:275368	15/47 (32%)
		C2H2 Zn finger	470..487	CDD:275368	4/16 (25%)
		zf-H2C2_2	482..507	CDD:290200	12/47 (26%)
		C2H2 Zn finger	498..518	CDD:275368	7/19 (37%)
		zf-H2C2_2	510..534	CDD:290200	10/23 (43%)
		C2H2 Zn finger	526..546	CDD:275368	5/19 (26%)
		zf-H2C2_2	539..563	CDD:290200	10/23 (43%)
		C2H2 Zn finger	554..574	CDD:275368	6/19 (32%)
		C2H2 Zn finger	582..602	CDD:275368	3/19 (16%)
ZNF517	NP_001371833.1	KRAB	14..73	CDD:214630	1/9 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	129..170		10/55 (18%)
		C2H2 Zn finger	180..199	CDD:275368	5/18 (28%)
		COG5048	<203..342	CDD:227381	47/139 (34%)
		C2H2 Zn finger	207..227	CDD:275368	8/19 (42%)
		C2H2 Zn finger	235..255	CDD:275368	6/20 (30%)
		C2H2 Zn finger	263..283	CDD:275368	7/19 (37%)
		COG5048	<287..459	CDD:227381	57/171 (33%)
		C2H2 Zn finger	291..311	CDD:275368	7/19 (37%)
		C2H2 Zn finger	319..339	CDD:275368	6/19 (32%)
		C2H2 Zn finger	370..390	CDD:275368	7/19 (37%)
		C2H2 Zn finger	398..418	CDD:275368	5/19 (26%)
		C2H2 Zn finger	426..446	CDD:275368	6/19 (32%)
		C2H2 Zn finger	454..474	CDD:275368	3/19 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	472..492		1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000