DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6654 and CG17612

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_608824.1	Gene:	CG17612 / 33639	FlyBaseID:	FBgn0031597	Length:	618	Species:	Drosophila melanogaster

Alignment Length:	738	Identity:	174/738 - (23%)
Similarity:	260/738 - (35%)	Gaps:	225/738 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VDKICLTCLSSTGPLLSIYDGGSGSCLADMIREFTKTKPRRNDNLPEKVCLSCL----------- 56
            ::.:|..|  ...|.||:..|||                     ||:.:||.||
  Fly     1 MENVCQCC--KVRPGLSVKRGGS---------------------LPKTLCLQCLHMDTFGTKHKG 42

  Fly    57 ----SEISNCYTFKIKCENSSRTLRQLLPNALPEEP------------DSKVSISC--------- 96
                ::|::    |:..|.|...     .:.|||.|            |:.:....
  Fly    43 PRPETQIND----KVHLEMSING-----EDGLPEHPLYPEVQLVVKEEDALIKKKVIEENHIHNE 98

  Fly    97 PVATTDQAVQTTSWEPDRCTASV------------------QTDAVTTTD--AEQNTSLIKSTIS 141
            .:......|.....|..|....|                  ..|.:...|  ||:...:||....
  Fly    99 EIIGASNIVDVEVHENHRANNDVILIQDSFAEEVILEDHPANNDVIIIQDSVAEEELPVIKEEAI 163

  Fly   142 VDLDYEGEGEVFDYELPDEPVEKTTSLILQVQGNLKDEKEVVFTQTNVIYEGDDHELEQQIRECN 206
            ...|.:||..:.. |..:||...:..:.|:...||          ||:.  .|.|:....|...
  Fly   164 EGEDLQGEYFIIT-ECLEEPAIGSCRVCLEQSDNL----------TNIF--DDAHQYGIPIATI- 214

  Fly   207 LAIFEGV-----DNEAEIITVTAPQVTTRKSAAKLLTQQEN--DKHQTPVGSKEEARELEKEQVP 264
            |:.:.|:     |:.:|.|.||...|.  |:|...|..:||  ..::.|   |||.  ::.:.:|
  Fly   215 LSQYTGMPVEKGDSFSEYICVTCLDVV--KNAFDDLESKENTIQMYRQP---KEEI--IDIDSIP 272

  Fly   265 QSAKRTSRRRGVVKQDVPATPPSDAEPSPKQHRLGTQRKLSAPRAGTVNGPSTTSGAATTPELKY 329
            ...|       .|..:|...||......||...|..  ||.| ...|.|...||.    .|.||
  Fly   273 VKNK-------PVDYEVTGKPPHRCPQCPKIFLLAA--KLQA-HIRTHNETRTTE----PPRLK- 322

  Fly   330 HCDRCNAGF----AVEKSLMIHR---RQKGCINRNYKCNECEKVFVSPDHLAEHQASHGAHNCPE 387
             |..|.:.:    .:|..:.|||   .::..:...|:|..|.|:|:....|..|..:|.
  Fly   323 -CPMCPSIYMKRGCLEAHMWIHRASDERESELEPPYRCPHCPKLFLYSSFLEIHIQTHE------ 380

  Fly   388 CGIRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSFTQN 452
                 |..:.||:.  ..||      |..|..||:.:|:|:||::||.||:.|.|.:|..||.:.
  Fly   381 -----DVSQRLSRK--SSHK------CAQCADVFSDVSSLKDHVKIHAGERTFKCPLCLMSFQEE 432

  Fly   453 ANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTSCSLAKHKRK 517
            :||:.|...|:.   |||..|...|.::..|..|                           .|:.
  Fly   433 SNLKSHDCAHTR---FKCHKCSKFFESQNYLDFH---------------------------FKKS 467

  Fly   518 HTGERPYACDLCPMRFTALNVLKNH---------RRTHTGERPYVCPFCSKTFTQRGDCQMHQRT 573
            ||.:.|:.|..|...|...|.||.|         .|:.:..:.:.||.|.|.|:...:.|||..|
  Fly   468 HTTKGPFKCIKCQQTFQKRNGLKEHISSQVCVQFLRSKSPGQIFPCPKCPKKFSIEDNYQMHHAT 532

  Fly   574 HQGERIYI----CPVCNEEFKSMPEMRSHLAGHEQHDKRLVH----FT--FL--------SNKEN 620
            |:..:..|    |..|.:.:::...:..|:..|    .|.||    ||  :|        |.:.|
  Fly   533 HKKVKTVIERHNCTQCKKSYQNKKLLTKHILSH----NRCVHCSMSFTSKYLLEQHTCSQSYQLN 593

  Fly   621 GS-GALEEELN-----EMTESAL 637
            || |.....||     |..||.|
  Fly   594 GSRGRKNPNLNYNECEESNESDL 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071	18/87 (21%)
		C2H2 Zn finger	331..354	CDD:275368	6/29 (21%)
		COG5048	<357..570	CDD:227381	59/221 (27%)
		C2H2 Zn finger	360..380	CDD:275368	6/19 (32%)
		C2H2 Zn finger	385..406	CDD:275370	3/20 (15%)
		C2H2 Zn finger	414..434	CDD:275368	8/19 (42%)
		zf-H2C2_2	427..451	CDD:290200	12/23 (52%)
		C2H2 Zn finger	442..490	CDD:275368	15/47 (32%)
		C2H2 Zn finger	470..487	CDD:275368	4/16 (25%)
		zf-H2C2_2	482..507	CDD:290200	2/24 (8%)
		C2H2 Zn finger	498..518	CDD:275368	1/19 (5%)
		zf-H2C2_2	510..534	CDD:290200	6/23 (26%)
		C2H2 Zn finger	526..546	CDD:275368	8/28 (29%)
		zf-H2C2_2	539..563	CDD:290200	9/32 (28%)
		C2H2 Zn finger	554..574	CDD:275368	8/19 (42%)
		C2H2 Zn finger	582..602	CDD:275368	3/19 (16%)
CG17612	NP_608824.1	zf-AD	187..>246	CDD:285071	18/73 (25%)
		C2H2 Zn finger	290..310	CDD:275368	6/22 (27%)
		C2H2 Zn finger	323..343	CDD:275370	3/19 (16%)
		zf-C2H2_8	356..438	CDD:292531	32/100 (32%)
		C2H2 Zn finger	359..379	CDD:275368	6/19 (32%)
		C2H2 Zn finger	394..414	CDD:275368	8/19 (42%)
		C2H2 Zn finger	422..438	CDD:275368	6/15 (40%)
		C2H2 Zn finger	447..463	CDD:275368	4/15 (27%)
		C2H2 Zn finger	476..505	CDD:275368	8/28 (29%)
		C2H2 Zn finger	513..533	CDD:275368	8/19 (42%)
		C2H2 Zn finger	545..565	CDD:275368	3/19 (16%)
		C2H2 Zn finger	568..584	CDD:275368	5/15 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	91	1.000	Inparanoid score	I2264
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24390
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.060