DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6654 and insm1b

DIOPT Version :9

Sequence 1:NP_650429.1 Gene:CG6654 / 41831 FlyBaseID:FBgn0038301 Length:639 Species:Drosophila melanogaster
Sequence 2:NP_955952.1 Gene:insm1b / 323882 ZFINID:ZDB-GENE-030131-2602 Length:453 Species:Danio rerio


Alignment Length:471 Identity:100/471 - (21%)
Similarity:165/471 - (35%) Gaps:139/471 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    85 PEEPDSKVSISCPVATTDQAVQTTSWEPDRCTASVQTDAVTTTDAEQNTSLIKSTISVDLDYEGE 149
            ||.|.:::::|.|..:..        :||                           |:.|.:...
Zfish    30 PECPIAQIALSSPAPSAS--------KPD---------------------------SILLAFPSA 59

  Fly   150 GEVFDYELPDEPVEKTTSLILQVQGNLKDEKEVVFTQTNVIYEGDDHELEQQIRECNL------- 207
            |.    |.| .||.|....     ||.:...:.:::.|..:  ..||:.:...|..||       
Zfish    60 GA----EAP-VPVHKPVQF-----GNPEAVYQALYSPTRPV--SKDHDRKYFERSLNLGSPISAE 112

  Fly   208 -----AIFEGVDNEAEIITVTAPQVTTRKSAAKLLTQQENDKHQTPVGSKEEARELEKEQV-PQS 266
                 |....:|:......|.....|:..:.:...:.......||  |:|..:.:..:.:| .:|
Zfish   113 SFPTPASLTSLDHHLLFAPVDLKIGTSNSNRSGTASGAHAPAIQT--GAKRPSADAAERKVSSKS 175

  Fly   267 AKRTSRRRGVVKQDVPATPPSDAEPSPKQHRLGTQRKLSAPRAGTVN-GPSTTSGAATTPELKYH 330
            ||:....|.:..:|...|.|.          ||.:.|     .|.|: .|..:||....|..::.
Zfish   176 AKKPKAIRKLNFEDEVTTSPV----------LGLKIK-----EGPVDLKPRPSSGGTNKPLGEFI 225

  Fly   331 CDRCNAGFAVEKSLMIHRRQKGCINRNYKCNECEKVFVSPDHLAEHQASH--------------- 380
            |..|...::...||..|:..: .:...|:|.||||||..|.:||.|:..|               
Zfish   226 CQLCKEEYSDPFSLAQHKCSR-IVRVEYRCPECEKVFSCPANLASHRRWHKPRVQSAPKQALQPA 289

  Fly   381 -----------------------------GAHNCPECGIRCDSKEALSKHMVQGHKRNLRNQCNI 416
                                         |.::|..||.|...:..|.||:: ||:. |:||  |
Zfish   290 KPFPEELRAEFPSDRDTPSPGLSESGSEDGLYDCQHCGKRFKRQAYLRKHIL-GHQA-LQNQ--I 350

  Fly   417 CQKVFTMLSTLRDHMRIHTGEKP----------FVCNICGKSFTQNANLRQH-KLRHSETKSFKC 470
            ..:.|....: .|.|.....:.|          ..|..||:.....|:|.:| :|.|.:.::|.|
Zfish   351 LGEAFRSAES-PDAMPSEDRQSPAPLNLSPADCLTCPACGEKLPNRASLERHLRLLHDDAQAFPC 414

  Fly   471 ELCPHSFVTKAELTSH 486
            :.||.:|.:...||.|
Zfish   415 KFCPATFYSSPGLTRH 430

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6654NP_650429.1 zf-AD 6..79 CDD:285071
C2H2 Zn finger 331..354 CDD:275368 5/22 (23%)
COG5048 <357..570 CDD:227381 47/185 (25%)
C2H2 Zn finger 360..380 CDD:275368 11/19 (58%)
C2H2 Zn finger 385..406 CDD:275370 7/20 (35%)
C2H2 Zn finger 414..434 CDD:275368 4/19 (21%)
zf-H2C2_2 427..451 CDD:290200 6/33 (18%)
C2H2 Zn finger 442..490 CDD:275368 16/46 (35%)
C2H2 Zn finger 470..487 CDD:275368 7/17 (41%)
zf-H2C2_2 482..507 CDD:290200 3/5 (60%)
C2H2 Zn finger 498..518 CDD:275368
zf-H2C2_2 510..534 CDD:290200
C2H2 Zn finger 526..546 CDD:275368
zf-H2C2_2 539..563 CDD:290200
C2H2 Zn finger 554..574 CDD:275368
C2H2 Zn finger 582..602 CDD:275368
insm1bNP_955952.1 SNAG domain. /evidence=ECO:0000250|UniProtKB:Q63ZV0 1..20
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 140..179 8/40 (20%)
C2H2 Zn finger 226..246 CDD:275368 5/19 (26%)
C2H2 Zn finger 254..274 CDD:275368 11/19 (58%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 298..318 0/19 (0%)
zf-C2H2 321..343 CDD:278523 7/22 (32%)
C2H2 Zn finger 323..340 CDD:275368 6/16 (38%)
C2H2 Zn finger 385..404 CDD:275368 6/18 (33%)
C2H2 Zn finger 414..435 CDD:275368 7/17 (41%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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