DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZBTB48

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001265576.1	Gene:	ZBTB48 / 3104	HGNCID:	4930	Length:	688	Species:	Homo sapiens

Alignment Length:	494	Identity:	139/494 - (28%)
Similarity:	208/494 - (42%)	Gaps:	82/494 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 LPDEPVEKTTSLILQVQ---GNLKDEKEVVFTQTNVIYEGDDH---ELEQQIRECNL-------- 207
            |.:|.|.:|..|:.:.|   |:...::..:.:...  .||...   :|:|.::.|.|
Human   148 LEEEEVSRTLGLVPRDQEPRGSHSPQRPQLHSPAQ--SEGPSSLCGKLKQALKPCPLEDKKPEDC 210

  Fly   208 -----------AIFEGVDNEAEIITVTAPQVTTRKSAAKLLTQQENDKHQTPVGSKEEARELEKE 261
                       |..:|..||.|::                 .|.|:|      |..:...|.|
Human   211 KVPPRPLEAEGAQLQGGSNEWEVV-----------------VQVEDD------GDGDYMSEPE-- 250

  Fly   262 QVPQSAKRTSRRRGVVKQDVPATPPSDA---EPSPKQHRLGTQRKLSAPRAGTVNGPSTTS---- 319
                 |..|.|:..|:::...|.|...|   ...|.::|.||...:..|   |.:....:.
Human   251 -----AVLTRRKSNVIRKPCAAEPALSAGSLAAEPAENRKGTAVPVECP---TCHKKFLSKYYLK 307

  Fly   320 --GAATTPELKYHCDRCNAGFAVEKSLMIHRRQKGCINRN---YKCNECEKVFVSPDHLAEHQAS 379
              ....|.|..:.|.:|...:..:::|:.| ..:.|:||:   :.|:.|::.|.....|..|..|
Human   308 VHNRKHTGEKPFECPKCGKCYFRKENLLEH-EARNCMNRSEQVFTCSVCQETFRRRMELRVHMVS 371

  Fly   380 HGA---HNCPECGIRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRI-HTGEKPF 440
            |..   :.|..|..:...|:.|..||::.|.....:.|..|.|.|...:.|:.|... |.|||.|
Human   372 HTGEMPYKCSSCSQQFMQKKDLQSHMIKLHGAPKPHACPTCAKCFLSRTELQLHEAFKHRGEKLF 436

  Fly   441 VCNICGKSFTQNANLRQH-KLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLAR 504
            ||..||...:....|:.| |.:|...:...||.|.|:|..||.|..|.|||||:|||:|.:|...
Human   437 VCEECGHRASSRNGLQMHIKAKHRNERPHVCEFCSHAFTQKANLNMHLRTHTGEKPFQCHLCGKT 501

  Fly   505 FTTSCSLAKHKRKHTGERPYACDLCPMRFTALNVLKNH-RRTHTGERPYVCPFCSKTFTQRGDCQ 568
            |.|..||.||.|.||||||::|:.|..|||....|..| ...|...||:.|..|.|||......:
Human   502 FRTQASLDKHNRTHTGERPFSCEFCEQRFTEKGPLLRHVASRHQEGRPHFCQICGKTFKAVEQLR 566

  Fly   569 MHQRTHQGERIYICPVCNEEFKSMPEMRSHLAGHEQHDK 607
            :|.|.|:|.|.:.|..|..:|.....:|.|:   |.||:
Human   567 VHVRRHKGVRKFECTECGYKFTRQAHLRRHM---EIHDR 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	4/22 (18%)
		COG5048	<357..570	CDD:227381	80/221 (36%)
		C2H2 Zn finger	360..380	CDD:275368	5/19 (26%)
		C2H2 Zn finger	385..406	CDD:275370	6/20 (30%)
		C2H2 Zn finger	414..434	CDD:275368	6/20 (30%)
		zf-H2C2_2	427..451	CDD:290200	11/24 (46%)
		C2H2 Zn finger	442..490	CDD:275368	17/48 (35%)
		C2H2 Zn finger	470..487	CDD:275368	8/16 (50%)
		zf-H2C2_2	482..507	CDD:290200	13/24 (54%)
		C2H2 Zn finger	498..518	CDD:275368	9/19 (47%)
		zf-H2C2_2	510..534	CDD:290200	14/23 (61%)
		C2H2 Zn finger	526..546	CDD:275368	7/20 (35%)
		zf-H2C2_2	539..563	CDD:290200	10/24 (42%)
		C2H2 Zn finger	554..574	CDD:275368	7/19 (37%)
		C2H2 Zn finger	582..602	CDD:275368	5/19 (26%)
ZBTB48	NP_001265576.1	BTB	16..119	CDD:306997
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	119..140
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	161..192		4/32 (13%)
		C2H2 Zn finger	293..313	CDD:275368	2/22 (9%)
		zf-H2C2_2	305..328	CDD:316026	4/22 (18%)
		C2H2 Zn finger	321..372	CDD:275368	12/51 (24%)
		SFP1	<374..459	CDD:227516	25/84 (30%)
		C2H2 Zn finger	380..401	CDD:275368	6/20 (30%)
		C2H2 Zn finger	409..425	CDD:275370	5/15 (33%)
		C2H2 Zn finger	438..459	CDD:275368	6/20 (30%)
		COG5048	<464..612	CDD:227381	60/142 (42%)
		C2H2 Zn finger	467..487	CDD:275368	10/19 (53%)
		C2H2 Zn finger	495..515	CDD:275368	9/19 (47%)
		C2H2 Zn finger	523..540	CDD:275368	6/16 (38%)
		C2H2 Zn finger	555..572	CDD:275368	6/16 (38%)
		C2H2 Zn finger	580..600	CDD:275368	6/22 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010