DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and Zfp532

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001100852.1	Gene:	Zfp532 / 307362	RGDID:	1311719	Length:	1332	Species:	Rattus norvegicus

Alignment Length:	803	Identity:	159/803 - (19%)
Similarity:	263/803 - (32%)	Gaps:	225/803 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CLTCLSSTGPLLSIYDGGSGSCL--------ADMIREFTKTKPRRNDNLPEKVCLSCLSEISNCY 63
            |:..:::    ||.....|.||.        |..:.:.....|:..|..||...|     |....
  Rat   302 CIAAIAA----LSAKKAASDSCKEPVANSREASPLPKEVNDSPKAADKSPESQNL-----IDGTK 357

  Fly    64 TFKIKCENSSRTLRQLLPNALPEEPDSKVSISCPVATTD-------QAVQTTSWEPDRCTASVQT 121
            ...:|..:|        |.::..|..||.|.|.||.:|.       :.::|:|.|..|....|..
  Rat   358 KASLKPSDS--------PRSVSSENSSKGSPSSPVGSTPAIPKVRIKTIKTSSGEIKRTVTRVLP 414

  Fly   122 DAVTTT---DAEQNTSLIKSTISVDLDYEGEGEVFDYELPDEPVEKTTSLILQVQGNLK-DEKEV 182
            :....:   .:||..|::.|..|: |.......|.. ..|..|:  .|:::.....:.: ..|:|
  Rat   415 EVDLDSGKKPSEQAASVMASVTSL-LSSSASAAVLS-SPPRAPL--PTAMVTSAVSSAELTPKQV 475

  Fly   183 -------VFTQTNVIYEGDDHELEQQIRECNLAIFEGVDNEAEIITVTAPQVTTRKSAAKLLTQQ 240
                   .|...:.:.......:       ||.:......:|.:|:..:.|     ||:..:.:.
  Rat   476 TIKPVATAFLPVSAVKTAGSQVI-------NLKLANNTTVKATVISAASVQ-----SASSAIIKA 528

  Fly   241 ENDKHQ----TPVGSKEEARELEK-------EQVPQSAKRTSRRRGV-------VKQDVPATPPS 287
            .|...|    .|..|...|:.:.|       ..:||.|:.||..|.|       :||.:  ...:
  Rat   529 ANAIQQQTVVVPASSLANAKLVPKTVHLANLNLLPQGAQATSELRQVLTKPQQQIKQAI--LNAA 591

  Fly   288 DAEPSPKQHRLGTQRKLSAPRAGTVN----------------GPSTTSGAATTPELKYHCDRCNA 336
            .|:|..|..|:.....|.:......|                .|..::| .|.|...|.|..|..
  Rat   592 AAQPPKKVSRVQVVSSLQSSVVEAFNKVLSSVNPVPVYIPNLSPPASAG-ITLPMRGYKCLECGD 655

  Fly   337 GFAVEKSLMIHRRQKGCINRNYKCNECEK--VFVSPDHLAEH-----------QASH-------- 380
            .||:||||..|..::. :.....||.|.|  ||.:...|..|           |.||
  Rat   656 SFALEKSLSQHYDRRS-VRIEVTCNHCTKNLVFYNKCSLLSHARGHKEKGVVMQCSHLILKPVPA 719

  Fly   381 -----------------------------------GA-------------------------HN- 384
                                               ||                         |:
  Rat   720 DQMIVSPSSNTAASTLPSSVGAATHTVAKVQPGLTGAVISAPPSTPISPAMPLDEDPSKLCRHSL 784

  Fly   385 -CPECGIRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCNICG-- 446
             |.||......:.:|:.|.........:..|.:||.:.....:...|.|||..:.|:.|..||
  Rat   785 KCLECNEVFQDETSLATHFQHAADTCGQKTCTVCQMLLPNQCSYASHQRIHQHKSPYTCPECGAI 849

  Fly   447 -KSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTSCS 510
             :|....:::.::.|.::....|:|..|...:...|.|.||.:....:..::|.:|...|.::.|
  Rat   850 CRSVHFQSHVTKNCLHYTRRVGFRCVHCNVVYSDVAALKSHIQGSHCEVFYKCPICPMAFKSAPS 914

  Fly   511 LAKHK-RKHTGER---P---YACDLCPMRFTALNVLKNHRRTHTGERP---YVCPFCSKTFTQRG 565
            ...|. .:|.|.:   |   |.|.:|...||...:|..|...|...:.   :.||.||..:.|:.
  Rat   915 THSHAYTQHPGVKIGEPKIIYKCSMCDTVFTLQTLLYRHFDQHIDNQKVSVFKCPDCSLLYAQKQ 979

  Fly   566 DCQMHQRTHQGERIYICPVCNEEFKSMPEMRSHL-----------AGHEQHDKRLVHFTFLSNKE 619
            ....|.::..|..        :..:..|.:..:|           |.|.:.|.:.:
  Rat   980 LMMDHIKSMHGTL--------KSIEGPPNLGINLPLSSKPATQNSANHSREDAKSM--------- 1027

  Fly   620 NGSGALEEE----LNEMTESALM 638
            ||...||::    ..:.|||..|
  Rat  1028 NGKEKLEKKSPSPAKKSTESKKM 1050

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071	15/79 (19%)
		C2H2 Zn finger	331..354	CDD:275368	9/22 (41%)
		COG5048	<357..570	CDD:227381	60/308 (19%)
		C2H2 Zn finger	360..380	CDD:275368	9/32 (28%)
		C2H2 Zn finger	385..406	CDD:275370	5/20 (25%)
		C2H2 Zn finger	414..434	CDD:275368	5/19 (26%)
		zf-H2C2_2	427..451	CDD:290200	9/26 (35%)
		C2H2 Zn finger	442..490	CDD:275368	12/50 (24%)
		C2H2 Zn finger	470..487	CDD:275368	5/16 (31%)
		zf-H2C2_2	482..507	CDD:290200	6/24 (25%)
		C2H2 Zn finger	498..518	CDD:275368	5/20 (25%)
		zf-H2C2_2	510..534	CDD:290200	8/30 (27%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		zf-H2C2_2	539..563	CDD:290200	7/26 (27%)
		C2H2 Zn finger	554..574	CDD:275368	6/19 (32%)
		C2H2 Zn finger	582..602	CDD:275368	3/30 (10%)
Zfp532	NP_001100852.1	C2H2 Zn finger	786..805	CDD:275368	5/18 (28%)
		C2H2 Zn finger	815..835	CDD:275368	5/19 (26%)
		C2H2 Zn finger	843..859	CDD:275368	4/15 (27%)
		C2H2 Zn finger	874..891	CDD:275368	5/16 (31%)
		C2H2 Zn finger	902..923	CDD:275368	5/20 (25%)
		C2H2 Zn finger	937..957	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1057..1077	CDD:275368
		C2H2 Zn finger	1087..1108	CDD:275368
		C2H2 Zn finger	1117..1137	CDD:275368
		C2H2 Zn finger	1207..1227	CDD:275368
		zf-C2H2_11	1230..1258	CDD:293228
		C2H2 Zn finger	1236..1257	CDD:275368
		C2H2 Zn finger	1297..1317	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000