DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and Zfp689

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_775452.1	Gene:	Zfp689 / 286996	RGDID:	628696	Length:	500	Species:	Rattus norvegicus

Alignment Length:	415	Identity:	133/415 - (32%)
Similarity:	181/415 - (43%)	Gaps:	80/415 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   264 PQSAKR--TSRRRGVVKQ---DVPATPPSDAEPSPKQHRLGTQRKLSAPR---AGTVNGPSTTSG 320
            ||..:|  |.:|:...:|   :....||.|.   |::.:.|  ||.|.||   ..|..||.....
  Rat    95 PQEYRRWVTFQRKTRTRQKNEEKEVFPPKDV---PRKGKRG--RKPSKPRLIARQTSGGPICPDC 154

  Fly   321 AATTPEL--------------KYHCDRCNAGFAVEKSLMIHRRQKG--CINRNYKCNECEKVFVS 369
            ..|.|:|              .|.|..|...|:....|:.|||...  |   .|.|::|.|.|..
  Rat   155 GCTFPDLPALESHKCAQNLKKPYPCPDCGRRFSYPSLLVSHRRAHSGEC---PYVCDQCGKRFSQ 216

  Fly   370 PDHLAEHQASHGA---HNCPECGIRCDSK-EALSKHMVQGHKRNLRNQCNICQKVFTMLSTLRDH 430
            ..:|::||..|..   ::||:|| ||..: .:|:.|... |.....:||..|.:.|...|.|..|
  Rat   217 RKNLSQHQVIHTGEKPYHCPDCG-RCFRRSRSLANHRTT-HTGEKPHQCPSCGRRFAYPSLLAIH 279

  Fly   431 MRIHTGEKPFVCNICGKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKP 495
            .|.||||||:.|..|.:.|.|...|..|:..|:..|.:.|..|...|.:.:.|.||.|.|:|::|
  Rat   280 QRTHTGEKPYTCLECSRRFRQRTALVIHQRIHTGEKPYPCPDCERRFSSSSRLVSHRRVHSGERP 344

  Fly   496 FECEVCLARFTTSCSLAKHKRKHTGERPY----------------------------ACDLCPMR 532
            :.||.|.|||:...:|.:|:..||||:||                            |||.|..|
  Rat   345 YACEHCEARFSQRSTLLQHQLLHTGEKPYPCPDCGRAFRRSGSLAIHRSTHTEEKLHACDDCGRR 409

  Fly   533 FTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQGERIYICPVCNEEFKSMPEMRS 597
            |...::|.:|||.|:|||||.|..|||.|.|......||..|.||:.:.|..|...|:    .|.
  Rat   410 FAYPSLLASHRRVHSGERPYACDLCSKRFAQWSHLAQHQLLHTGEKPFPCLECGRCFR----QRW 470

  Fly   598 HLAGHEQHDKRLVHFTFLSNKENGS 622
            .||.|:          ...|..|||
  Rat   471 SLAVHK----------CCPNTHNGS 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	7/24 (29%)
		COG5048	<357..570	CDD:227381	86/244 (35%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
		C2H2 Zn finger	385..406	CDD:275370	8/21 (38%)
		C2H2 Zn finger	414..434	CDD:275368	7/19 (37%)
		zf-H2C2_2	427..451	CDD:290200	12/23 (52%)
		C2H2 Zn finger	442..490	CDD:275368	15/47 (32%)
		C2H2 Zn finger	470..487	CDD:275368	5/16 (31%)
		zf-H2C2_2	482..507	CDD:290200	13/24 (54%)
		C2H2 Zn finger	498..518	CDD:275368	8/19 (42%)
		zf-H2C2_2	510..534	CDD:290200	13/51 (25%)
		C2H2 Zn finger	526..546	CDD:275368	9/19 (47%)
		zf-H2C2_2	539..563	CDD:290200	15/23 (65%)
		C2H2 Zn finger	554..574	CDD:275368	8/19 (42%)
		C2H2 Zn finger	582..602	CDD:275368	6/19 (32%)
Zfp689	NP_775452.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		KRAB	29..88	CDD:214630
		KRAB	29..68	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	110..144		11/38 (29%)
		C2H2 Zn finger	151..171	CDD:275368	3/19 (16%)
		COG5048	159..>466	CDD:227381	104/311 (33%)
		C2H2 Zn finger	179..199	CDD:275368	7/19 (37%)
		C2H2 Zn finger	207..227	CDD:275368	7/19 (37%)
		zf-H2C2_2	219..244	CDD:290200	10/25 (40%)
		C2H2 Zn finger	235..255	CDD:275368	8/21 (38%)
		zf-H2C2_2	247..272	CDD:290200	7/25 (28%)
		C2H2 Zn finger	263..283	CDD:275368	7/19 (37%)
		zf-H2C2_2	276..300	CDD:290200	12/23 (52%)
		C2H2 Zn finger	291..311	CDD:275368	6/19 (32%)
		zf-H2C2_2	303..328	CDD:290200	7/24 (29%)
		C2H2 Zn finger	319..339	CDD:275368	7/19 (37%)
		zf-H2C2_2	332..356	CDD:290200	13/23 (57%)
		C2H2 Zn finger	347..367	CDD:275368	8/19 (42%)
		zf-H2C2_2	360..384	CDD:290200	8/23 (35%)
		C2H2 Zn finger	375..395	CDD:275368	0/19 (0%)
		C2H2 Zn finger	403..423	CDD:275368	9/19 (47%)
		zf-H2C2_2	416..440	CDD:290200	15/23 (65%)
		C2H2 Zn finger	431..451	CDD:275368	8/19 (42%)
		C2H2 Zn finger	459..475	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000