DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6654 and ZNF875

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	XP_016882161.1	Gene:	ZNF875 / 284459	HGNCID:	4928	Length:	704	Species:	Homo sapiens

Alignment Length:	436	Identity:	125/436 - (28%)
Similarity:	184/436 - (42%)	Gaps:	57/436 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 IYEGDDHELEQQIRECNLAIFEGVDNEAEIITVTAPQVTTRKSAAKLLTQQENDKHQTPVGSKEE 254
            |.||:|..|          :|..|........:::|....:.:      |.:.|.....:||..|
Human   219 IQEGEDSRL----------LFGRVSKNGTSKALSSPPEEQQPA------QSKEDNTVVDIGSSPE 267

  Fly   255 AR-------------------ELEKEQVPQSAKRTSRRRGVVKQDVPATPPSDAEPSPKQHRLGT 300
            .|                   |::.|:......:.|....:.|.....||....|....   .|:
Human   268 RRADLEETDKVLHGLEVSGFGEIKYEEFGPGFIKESNLLSLQKTQTGETPYMYTEWGDS---FGS 329

  Fly   301 QRKLSAPRAGTVNGPSTTSGAATTPELKYHCDRCNAGFAVEKSLMIHRR-QKGCINRNYKCNECE 364
            ...|       :..|.|.||..     .|.|..|..||..:.:|:.|:| ..|  .:.|.|.:|.
Human   330 MSVL-------IKNPRTHSGGK-----PYVCRECGRGFTWKSNLITHQRTHSG--EKPYVCKDCG 380

  Fly   365 KVFVSPDHLAEHQASHGA---HNCPECGIRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLST 426
            :.|....:|..||.:|..   :.|.|||.....|..|..|. :.|.......|..|.:.|...|.
Human   381 RGFTWKSNLFTHQRTHSGLKPYVCKECGQSFSLKSNLITHQ-RAHTGEKPYVCRECGRGFRQHSH 444

  Fly   427 LRDHMRIHTGEKPFVCNICGKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHT 491
            |..|.|.|:||||::|..|.:.|:|.::|.:|...|:..|.:.|..|...|..|:.|.:|.|||:
Human   445 LVRHKRTHSGEKPYICRECEQGFSQKSHLIRHLRTHTGEKPYVCTECGRHFSWKSNLKTHQRTHS 509

  Fly   492 GDKPFECEVCLARFTTSCSLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPF 556
            |.||:.|..|...|:...:|.||:|.||||:|:.|..|...||..:.|..|:|||:||:|:||..
Human   510 GVKPYVCLECGQCFSLKSNLNKHQRSHTGEKPFVCTECGRGFTRKSTLSTHQRTHSGEKPFVCAE 574

  Fly   557 CSKTFTQRGDCQMHQRTHQGERIYICPVCNEEFKSMPEMRSHLAGH 602
            |.:.|..:.....|||||.||:.::|..|...|:..|.:..|...|
Human   575 CGRGFNDKSTLISHQRTHSGEKPFMCRECGRRFRQKPNLFRHKRAH 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	8/23 (35%)
		COG5048	<357..570	CDD:227381	76/215 (35%)
		C2H2 Zn finger	360..380	CDD:275368	6/19 (32%)
		C2H2 Zn finger	385..406	CDD:275370	7/20 (35%)
		C2H2 Zn finger	414..434	CDD:275368	7/19 (37%)
		zf-H2C2_2	427..451	CDD:290200	11/23 (48%)
		C2H2 Zn finger	442..490	CDD:275368	15/47 (32%)
		C2H2 Zn finger	470..487	CDD:275368	5/16 (31%)
		zf-H2C2_2	482..507	CDD:290200	11/24 (46%)
		C2H2 Zn finger	498..518	CDD:275368	7/19 (37%)
		zf-H2C2_2	510..534	CDD:290200	11/23 (48%)
		C2H2 Zn finger	526..546	CDD:275368	7/19 (37%)
		zf-H2C2_2	539..563	CDD:290200	12/23 (52%)
		C2H2 Zn finger	554..574	CDD:275368	6/19 (32%)
		C2H2 Zn finger	582..602	CDD:275368	5/19 (26%)
ZNF875	XP_016882161.1	KRAB	77..136	CDD:214630
		C2H2 Zn finger	324..340	CDD:275368	3/25 (12%)
		COG5048	344..703	CDD:227381	98/285 (34%)
		C2H2 Zn finger	348..368	CDD:275368	7/19 (37%)
		C2H2 Zn finger	376..396	CDD:275368	6/19 (32%)
		C2H2 Zn finger	404..424	CDD:275368	7/20 (35%)
		C2H2 Zn finger	432..452	CDD:275368	7/19 (37%)
		C2H2 Zn finger	460..480	CDD:275368	6/19 (32%)
		C2H2 Zn finger	488..508	CDD:275368	7/19 (37%)
		C2H2 Zn finger	516..536	CDD:275368	7/19 (37%)
		C2H2 Zn finger	544..564	CDD:275368	7/19 (37%)
		C2H2 Zn finger	572..592	CDD:275368	6/19 (32%)
		C2H2 Zn finger	600..620	CDD:275368	5/19 (26%)
		C2H2 Zn finger	626..646	CDD:275368
		C2H2 Zn finger	654..674	CDD:275368
		C2H2 Zn finger	682..702	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910