DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZNF844

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	XP_016882153.1	Gene:	ZNF844 / 284391	HGNCID:	25932	Length:	668	Species:	Homo sapiens

Alignment Length:	277	Identity:	92/277 - (33%)
Similarity:	137/277 - (49%)	Gaps:	27/277 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   342 KSLMIHRRQKGCINRNYKCNEC-EKVFVSPDHLAEHQASHGAHNCPE--CG------------IR 391
            :||:..|     ::.|.:.|.| |.....||.....:.|.|..:|..  ||            ||
Human    66 RSLLGER-----VDENTEENHCGETSSQIPDDTLNKKTSPGVKSCESSVCGEVFVGHSSLNRHIR 125

  Fly   392 CDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSFTQNANLR 456
            .|:....|::...|.:   ..:|...:|.|....:.:...:.|||||.:.|..|||:|..:::::
Human   126 ADTAHKPSEYQEYGQE---PYKCQQRKKAFRCHPSFQMQEKAHTGEKLYDCKECGKTFISHSSIQ 187

  Fly   457 QHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTSCSLAKHKRKHTGE 521
            :|.:.|:...::||:.|..:....:....|.|.|||:||::|:.|...|:.|.||..|:|.||||
Human   188 RHMIMHNGDGTYKCKFCGKACPCLSIYLIHERVHTGEKPYKCKQCGKAFSYSTSLQIHERTHTGE 252

  Fly   522 RPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQGERIYICPVCN 586
            :||.|..|...|.:.|.|..||||||||:||.|..|.|.|......|:|:|||..|:.|.|..|.
Human   253 KPYECKECGKAFGSPNSLYEHRRTHTGEKPYECKQCGKAFRWFHSFQIHERTHSEEKAYECTKCG 317

  Fly   587 EEFKSMPEMRSHLAGHE 603
            :.||    ..|:|..||
Human   318 KAFK----CPSYLCRHE 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	3/11 (27%)
		COG5048	<357..570	CDD:227381	75/227 (33%)
		C2H2 Zn finger	360..380	CDD:275368	5/20 (25%)
		C2H2 Zn finger	385..406	CDD:275370	7/34 (21%)
		C2H2 Zn finger	414..434	CDD:275368	3/19 (16%)
		zf-H2C2_2	427..451	CDD:290200	10/23 (43%)
		C2H2 Zn finger	442..490	CDD:275368	12/47 (26%)
		C2H2 Zn finger	470..487	CDD:275368	2/16 (13%)
		zf-H2C2_2	482..507	CDD:290200	10/24 (42%)
		C2H2 Zn finger	498..518	CDD:275368	8/19 (42%)
		zf-H2C2_2	510..534	CDD:290200	12/23 (52%)
		C2H2 Zn finger	526..546	CDD:275368	8/19 (42%)
		zf-H2C2_2	539..563	CDD:290200	15/23 (65%)
		C2H2 Zn finger	554..574	CDD:275368	7/19 (37%)
		C2H2 Zn finger	582..602	CDD:275368	6/19 (32%)
ZNF844	XP_016882153.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000