DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZNF544

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001374339.1	Gene:	ZNF544 / 27300	HGNCID:	16759	Length:	769	Species:	Homo sapiens

Alignment Length:	640	Identity:	167/640 - (26%)
Similarity:	248/640 - (38%)	Gaps:	120/640 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 CLSEISNCYTFKIKCENSSRTLRQLLPNALPEEPDSKVSISCPVATTDQAVQTTSWEPDRCTASV 119
            |..:::..:| :.:.|......|.|......|..:..||:...::.:| .:.....|.|.|.|..
Human    69 CFEDVAMAFT-QEEWEQLDLAQRTLYREVTLETWEHIVSLGLFLSKSD-VISQLEQEEDLCRAEQ 131

  Fly   120 QTDAVTTTDAEQN-----TSLIKSTISVDLDYEGEGEVFDYELPDEPVEKTTSLILQVQGNLKDE 179
            :.........|:|     ....:..:|..::....|       |:||    .||:|   |.::|
Human   132 EAPRDWKATLEENRLNSEKDRAREELSHHVEVYRSG-------PEEP----PSLVL---GKVQD- 181

  Fly   180 KEVVFTQTNVIYEGDDHELE----------QQIRECNLAIFEG--VDNEAEIITVTAP------- 225
                  |:|.:.|..::.|.          .|...|.|.:..|  :.:...::..|.|
Human   182 ------QSNQLREHQENSLRFMVLTSERLFAQREHCELELGGGYSLPSTLSLLPTTLPTSTGFPK 240

  Fly   226 ---QVTTRKSAAKLLTQQEN-------DKHQ-----------TPVGSKEEARELEKEQVPQSAKR 269
               ||...|..:..:..::|       :.||           :.:|:.|..::...|.:......
Human   241 PNSQVKELKQNSAFINHEKNGADGKHCESHQCARAFCQSIYLSKLGNVETGKKNPYEYIVSGDSL 305

  Fly   270 T--------SRRRGVVKQD------------VPATPPSDAEPSPKQHRLGTQRKLSAPRAGTV-- 312
            .        .|...|.|.|            |.............|:.....|:..:.....|
Human   306 NYGSSLCFHGRTFSVKKSDDCKDYGNLFSHSVSLNEQKPVHFGKSQYECDECRETCSESLCLVQT 370

  Fly   313 --NGPSTT-------------------SGAATTPELKYHCDRCNAGFAVEKSLMIHRR-QKGCIN 355
              :||..|                   .....|.|....|::|...|:..|  :||:| ..|  .
Human   371 ERSGPGETPFRCEERCAAFPMASSFSDCNIIQTTEKPSVCNQCGKSFSCCK--LIHQRTHTG--E 431

  Fly   356 RNYKCNECEKVFVSPDHLAEHQASHGA---HNCPECGIRCDSKEALSKHMVQGHKRNLRNQCNIC 417
            :.::|.:|.|.|.....|..||.:|..   :.|..||.....:..|..|. :.|......||..|
Human   432 KPFECTQCGKSFSQSYDLVIHQRTHTGEKPYECDLCGKSFTQRSKLITHQ-RIHTGEKPYQCIEC 495

  Fly   418 QKVFTMLSTLRDHMRIHTGEKPFVCNICGKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAE 482
            :|.|...|.|..|.||||||||:.|..|||||:|:..|..||..|:..|.|||..|..||..|.:
Human   496 RKSFRWNSNLIVHQRIHTGEKPYECTHCGKSFSQSYELVTHKRTHTGEKPFKCTQCGKSFSQKYD 560

  Fly   483 LTSHARTHTGDKPFECEVCLARFTTSCSLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHT 547
            |..|.|||||:||:||.:|...|:.|..|..|:|.||||:||.|..|...|...:.|..|:|.||
Human   561 LVVHQRTHTGEKPYECNLCGKSFSQSSKLITHQRIHTGEKPYQCIECGKSFRWNSNLVIHQRIHT 625

  Fly   548 GERPYVCPFCSKTFTQRGDCQMHQRTHQGERIYICPVCNEEFKSMPEMRSHLAGH 602
            ||:||.|..|.|:|:|......|:|||.||:.|.|..|.:.|....::..||..|
Human   626 GEKPYDCTHCGKSFSQSYQLVAHKRTHTGEKPYECNECGKAFNRSTQLIRHLQIH 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071	4/23 (17%)
		C2H2 Zn finger	331..354	CDD:275368	8/23 (35%)
		COG5048	<357..570	CDD:227381	89/215 (41%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
		C2H2 Zn finger	385..406	CDD:275370	5/20 (25%)
		C2H2 Zn finger	414..434	CDD:275368	8/19 (42%)
		zf-H2C2_2	427..451	CDD:290200	16/23 (70%)
		C2H2 Zn finger	442..490	CDD:275368	22/47 (47%)
		C2H2 Zn finger	470..487	CDD:275368	6/16 (38%)
		zf-H2C2_2	482..507	CDD:290200	13/24 (54%)
		C2H2 Zn finger	498..518	CDD:275368	7/19 (37%)
		zf-H2C2_2	510..534	CDD:290200	11/23 (48%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		zf-H2C2_2	539..563	CDD:290200	13/23 (57%)
		C2H2 Zn finger	554..574	CDD:275368	7/19 (37%)
		C2H2 Zn finger	582..602	CDD:275368	5/19 (26%)
ZNF544	NP_001374339.1	KRAB	68..127	CDD:214630	11/59 (19%)
		C2H2 Zn finger	410..428	CDD:275368	7/19 (37%)
		zf-H2C2_2	424..445	CDD:404364	7/22 (32%)
		C2H2 Zn finger	436..456	CDD:275368	7/19 (37%)
		COG5048	460..>753	CDD:227381	94/222 (42%)
		C2H2 Zn finger	464..484	CDD:275368	5/20 (25%)
		C2H2 Zn finger	492..512	CDD:275368	8/19 (42%)
		C2H2 Zn finger	520..540	CDD:275368	10/19 (53%)
		C2H2 Zn finger	548..568	CDD:275368	8/19 (42%)
		C2H2 Zn finger	576..596	CDD:275368	7/19 (37%)
		C2H2 Zn finger	604..624	CDD:275368	6/19 (32%)
		C2H2 Zn finger	632..652	CDD:275368	7/19 (37%)
		C2H2 Zn finger	660..680	CDD:275368	5/19 (26%)
		C2H2 Zn finger	688..708	CDD:275368
		C2H2 Zn finger	716..736	CDD:275368
		C2H2 Zn finger	744..764	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910