DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZNF285

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001278417.1	Gene:	ZNF285 / 26974	HGNCID:	13079	Length:	597	Species:	Homo sapiens

Alignment Length:	508	Identity:	148/508 - (29%)
Similarity:	211/508 - (41%)	Gaps:	87/508 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 DDHELEQQIRECNLAIFEGVDNEAEIIT-------VTA----PQVTTRKS--AAKLLTQQENDKH 245
            :|..|.::....:|.|.|   ||..::.       :||    .||.|.:|  .|.::|:.:|.:.
Human   110 EDVSLSEEWAGISLQISE---NENYVVNAIIKNQDITAWQSLTQVLTPESWRKANIMTEPQNSQG 171

  Fly   246 QTPVGSKEEARELEKEQVPQSAKRTS---RRRGVVKQDVPATPPSDAEPSPKQHRLG---TQRKL 304
            :.. |...|.:...:.|...|...||   ......|.:.|...||..:      .||   |..|.
Human   172 RYK-GIYMEEKLYRRAQHDDSLSWTSCDHHESQECKGEDPGRHPSCGK------NLGMKSTVEKR 229

  Fly   305 SAPRAGTVNGPSTTSGAA----TTP---------ELKYHCDRCNAGFAVEKSLMIHRR------- 349
            :|........|....|.|    |.|         |..|.||:....|:..:.|::|.:
Human   230 NAAHVLPQPFPCNNCGVAFADDTDPHVHHSTHLGEKSYKCDQYGKNFSQSQDLIVHCKTHSGKTP 294

  Fly   350 ------QKGCI--------------NRNYKCNECEKVFVSPDHLAEHQASHGA---HNCPECGIR 391
                  ..||.              ::.|||.||.|.|.....|..|...|..   :.|.|||..
Human   295 YEFHEWPMGCKQSSDLPRYQKVSSGDKPYKCKECGKGFRRSSSLHNHHRVHTGEMPYKCDECGKG 359

  Fly   392 CDSKEALSKHMVQG-HKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSFTQNANL 455
            ...:..|..|  || |......:|..|.|.|...|.|..|.|:||||||:.|:.|||.|:.::.|
Human   360 FGFRSLLCIH--QGVHTGKKPYKCEECGKGFDQSSNLLVHQRVHTGEKPYKCSECGKCFSSSSVL 422

  Fly   456 RQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTSCSLAKHKRKHTG 520
            :.|...|:..|.::|..|...|.....|..|.|.|||:||::|.||...|..|..|..|:|.|||
Human   423 QVHWRFHTGEKPYRCGECGKGFSQCTHLHIHQRVHTGEKPYKCNVCGKDFAYSSVLHTHQRVHTG 487

  Fly   521 ERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQGERIYICPVC 585
            |:||.|::|...|:..:....|:|.|..|:||.|..|.|.|::..|..:|.|.|.|||.|.|..|
Human   488 EKPYKCEVCGKCFSYSSYFHLHQRDHIREKPYKCDECGKGFSRNSDLNVHLRVHTGERPYKCKAC 552

  Fly   586 NEEFKSMPEMRSHLAGHEQHDKRLVHF--TFLSNKENGSGAL-EEELNEMTES 635
            .:.|    ...|:|..|::     ||.  |..::.|.|...| .:.|:|..|:
Human   553 GKGF----SRNSYLLAHQR-----VHIDETQYTHCERGKDLLTHQRLHEQRET 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	6/35 (17%)
		COG5048	<357..570	CDD:227381	81/216 (38%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
		C2H2 Zn finger	385..406	CDD:275370	8/21 (38%)
		C2H2 Zn finger	414..434	CDD:275368	8/19 (42%)
		zf-H2C2_2	427..451	CDD:290200	14/23 (61%)
		C2H2 Zn finger	442..490	CDD:275368	15/47 (32%)
		C2H2 Zn finger	470..487	CDD:275368	4/16 (25%)
		zf-H2C2_2	482..507	CDD:290200	12/24 (50%)
		C2H2 Zn finger	498..518	CDD:275368	8/19 (42%)
		zf-H2C2_2	510..534	CDD:290200	11/23 (48%)
		C2H2 Zn finger	526..546	CDD:275368	5/19 (26%)
		zf-H2C2_2	539..563	CDD:290200	10/23 (43%)
		C2H2 Zn finger	554..574	CDD:275368	7/19 (37%)
		C2H2 Zn finger	582..602	CDD:275368	5/19 (26%)
ZNF285	NP_001278417.1	KRAB	15..54	CDD:279668
		KRAB	15..>52	CDD:214630
		C2H2 Zn finger	214..233	CDD:275368	7/24 (29%)
		COG5048	236..569	CDD:227381	108/343 (31%)
		C2H2 Zn finger	241..261	CDD:275368	4/19 (21%)
		C2H2 Zn finger	269..289	CDD:275368	5/19 (26%)
		zf-C2H2	323..345	CDD:278523	9/21 (43%)
		C2H2 Zn finger	325..345	CDD:275368	7/19 (37%)
		C2H2 Zn finger	353..373	CDD:275368	8/21 (38%)
		C2H2 Zn finger	381..401	CDD:275368	8/19 (42%)
		zf-H2C2_2	393..418	CDD:290200	14/24 (58%)
		C2H2 Zn finger	409..429	CDD:275368	7/19 (37%)
		C2H2 Zn finger	437..457	CDD:275368	6/19 (32%)
		zf-H2C2_2	453..474	CDD:290200	11/20 (55%)
		C2H2 Zn finger	465..485	CDD:275368	8/19 (42%)
		zf-H2C2_2	480..502	CDD:290200	11/21 (52%)
		C2H2 Zn finger	493..513	CDD:275368	5/19 (26%)
		zf-C2H2	519..541	CDD:278523	8/21 (38%)
		C2H2 Zn finger	521..541	CDD:275368	7/19 (37%)
		zf-H2C2_2	533..558	CDD:290200	11/28 (39%)
		C2H2 Zn finger	549..569	CDD:275368	6/28 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910