DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZNF337

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001277190.1	Gene:	ZNF337 / 26152	HGNCID:	15809	Length:	751	Species:	Homo sapiens

Alignment Length:	473	Identity:	128/473 - (27%)
Similarity:	192/473 - (40%)	Gaps:	116/473 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   241 ENDKHQTPVG---SKEE-ARELEKEQVPQSAKRTSRRR-----GVVKQDV--------------- 281
            ||..|...:|   ||.| .|.||:.:||...:|  |||     |:..:.|
Human    43 ENYSHLVSLGILHSKPELIRRLEQGEVPWGEER--RRRPGPCAGIYAEHVLRPKNLGLAHQRQQQ 105

  Fly   282 -------------------PATPPSDAEPSPKQHRLGTQRKLSAPRAGTVNG------------- 314
                               .:|.|......|.:|.:.::|:.|.....:..|
Human   106 LQFSDQSFQSDTAEGQEKEKSTKPMAFSSPPLRHAVSSRRRNSVVEIESSQGQRENPTEIDKVLK 170

  Fly   315 --PSTTSGA---------------------ATTPELKYHCDRCNAGFAVEKSLMIHRR-QKGCIN 355
              .::..||                     |.:.:..:.|..|:.||..|.:|::|:. ..|  .
Human   171 GIENSRWGAFKCAERGQDFSRKMMVIIHKKAHSRQKLFTCRECHQGFRDESALLLHQNTHTG--E 233

  Fly   356 RNYKCNECEKVFVSPDHLAEHQASHGAHN---CPECGIRCDSKEALSKHMVQGHKRNLRNQCNIC 417
            ::|.|:.|.:.|....:|..||.:|....   |..||....||..|:.| .:.|......:|..|
Human   234 KSYVCSVCGRGFSLKANLLRHQRTHSGEKPFLCKVCGRGYTSKSYLTVH-ERTHTGEKPYECQEC 297

  Fly   418 QKVFTMLSTLRDHMRIHTGEKPFVCNICGKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAE 482
            .:.|...|:...|::.|:|||||||..||:.:|..:....||..||..|.::|:.|...|..|:.
Human   298 GRRFNDKSSYNKHLKAHSGEKPFVCKECGRGYTNKSYFVVHKRIHSGEKPYRCQECGRGFSNKSH 362

  Fly   483 LTSHARTHTGDKPFECEVCLARFTTSCSLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHT 547
            |.:|.|||:|:|||.|..|...|:...||.:|:|.|:||:|:.|..|...|:..:.|..|:|||:
Human   363 LITHQRTHSGEKPFACRQCKQSFSVKGSLLRHQRTHSGEKPFVCKDCERSFSQKSTLVYHQRTHS 427

  Fly   548 GERPYVC------------------------PF----CSKTFTQRGDCQMHQRTHQGERIYICPV 584
            ||:|:||                        ||    |.:.|.|:....:|||||..|:.|.|..
Human   428 GEKPFVCRECGQGFIQKSTLVKHQITHSEEKPFVCKDCGRGFIQKSTFTLHQRTHSEEKPYGCRE 492

  Fly   585 CNEEFKSMPEMRSHLAGH 602
            |...|:.......||..|
Human   493 CGRRFRDKSSYNKHLRAH 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	8/23 (35%)
		COG5048	<357..570	CDD:227381	79/243 (33%)
		C2H2 Zn finger	360..380	CDD:275368	6/19 (32%)
		C2H2 Zn finger	385..406	CDD:275370	7/20 (35%)
		C2H2 Zn finger	414..434	CDD:275368	5/19 (26%)
		zf-H2C2_2	427..451	CDD:290200	11/23 (48%)
		C2H2 Zn finger	442..490	CDD:275368	16/47 (34%)
		C2H2 Zn finger	470..487	CDD:275368	5/16 (31%)
		zf-H2C2_2	482..507	CDD:290200	12/24 (50%)
		C2H2 Zn finger	498..518	CDD:275368	7/19 (37%)
		zf-H2C2_2	510..534	CDD:290200	10/23 (43%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		zf-H2C2_2	539..563	CDD:290200	14/51 (27%)
		C2H2 Zn finger	554..574	CDD:275368	9/47 (19%)
		C2H2 Zn finger	582..602	CDD:275368	5/19 (26%)
ZNF337	NP_001277190.1	zf-H2C2_2	699..724	CDD:290200
		C2H2 Zn finger	715..735	CDD:275368
		KRAB	12..71	CDD:214630	11/27 (41%)
		KRAB	12..51	CDD:279668	3/7 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	101..163		7/61 (11%)
		C2H2 Zn finger	182..202	CDD:275368	0/19 (0%)
		C2H2 Zn finger	210..230	CDD:275368	7/19 (37%)
		COG5048	234..626	CDD:227381	92/278 (33%)
		C2H2 Zn finger	238..258	CDD:275368	6/19 (32%)
		zf-H2C2_2	250..275	CDD:290200	7/24 (29%)
		C2H2 Zn finger	266..286	CDD:275368	7/20 (35%)
		zf-H2C2_2	278..302	CDD:290200	5/24 (21%)
		C2H2 Zn finger	294..314	CDD:275368	5/19 (26%)
		C2H2 Zn finger	322..342	CDD:275368	6/19 (32%)
		zf-C2H2	348..370	CDD:278523	7/21 (33%)
		C2H2 Zn finger	350..370	CDD:275368	7/19 (37%)
		C2H2 Zn finger	378..398	CDD:275368	7/19 (37%)
		zf-H2C2_2	390..415	CDD:290200	11/24 (46%)
		C2H2 Zn finger	406..426	CDD:275368	6/19 (32%)
		C2H2 Zn finger	434..454	CDD:275368	1/19 (5%)
		C2H2 Zn finger	462..482	CDD:275368	6/19 (32%)
		C2H2 Zn finger	490..510	CDD:275368	5/19 (26%)
		C2H2 Zn finger	518..538	CDD:275368
		zf-H2C2_2	530..554	CDD:290200
		C2H2 Zn finger	546..566	CDD:275368
		C2H2 Zn finger	574..594	CDD:275368
		DUF4193	<600..633	CDD:290546
		C2H2 Zn finger	602..622	CDD:275368
		C2H2 Zn finger	630..650	CDD:275368
		zf-H2C2_2	642..666	CDD:290200
		C2H2 Zn finger	658..679	CDD:275368
		C2H2 Zn finger	687..707	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9604
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000