DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZNF473

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001006657.1	Gene:	ZNF473 / 25888	HGNCID:	23239	Length:	871	Species:	Homo sapiens

Alignment Length:	329	Identity:	110/329 - (33%)
Similarity:	149/329 - (45%)	Gaps:	48/329 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   324 TPELKYHCDRCNAGFAVEKSL----MIHRRQK-------GCINRN-------YKCNECEKVFVSP 370
            |.:..|.|..|...|....:|    .:|.|:|       ..:::|       :|||:|||.|...
Human   510 TVKTPYECQECGERFICGSTLKCHESVHAREKQGFFVSGKILDQNPEQKEKCFKCNKCEKTFSCS 574

  Fly   371 DHLAEHQASH----GAHNCPECG------------IRCDSKEALSKHMVQG-------------- 405
            .:|.:|:..|    ....|.:||            .|..|:..|.|...||
Human   575 KYLTQHERIHTRGVKPFECDQCGKAFGQSTRLIHHQRIHSRVRLYKWGEQGKAISSASLIKLQSF 639

  Fly   406 HKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSFTQNANLRQHKLRHSETKSFKC 470
            |.:....:||.|.|.|:..:.|..|..||.||.||.|:.|.:.|||...|.||:..|:..|...|
Human   640 HTKEHPFKCNECGKTFSHSAHLSKHQLIHAGENPFKCSKCDRVFTQRNYLVQHERTHARKKPLVC 704

  Fly   471 ELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTSCSLAKHKRKHTGERPYACDLCPMRFTA 535
            ..|..:|...:.|:.|.|.|:|:||:.|:.|...|..|..|.:|:|.||||:||.|..|...||.
Human   705 NECGKTFRQSSCLSKHQRIHSGEKPYVCDYCGKAFGLSAELVRHQRIHTGEKPYVCQECGKAFTQ 769

  Fly   536 LNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQGERIYICPVCNEEFKSMPEMRSHLA 600
            .:.|..|||.||||:||.|..|.|.|.|:.:...|||.|.||:.|.|.||.:.|.....:..||.
Human   770 SSCLSIHRRVHTGEKPYRCGECGKAFAQKANLTQHQRIHTGEKPYSCNVCGKAFVLSAHLNQHLR 834

  Fly   601 GHEQ 604
            .|.|
Human   835 VHTQ 838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	7/33 (21%)
		COG5048	<357..570	CDD:227381	86/249 (35%)
		C2H2 Zn finger	360..380	CDD:275368	8/19 (42%)
		C2H2 Zn finger	385..406	CDD:275370	9/46 (20%)
		C2H2 Zn finger	414..434	CDD:275368	7/19 (37%)
		zf-H2C2_2	427..451	CDD:290200	11/23 (48%)
		C2H2 Zn finger	442..490	CDD:275368	16/47 (34%)
		C2H2 Zn finger	470..487	CDD:275368	4/16 (25%)
		zf-H2C2_2	482..507	CDD:290200	10/24 (42%)
		C2H2 Zn finger	498..518	CDD:275368	7/19 (37%)
		zf-H2C2_2	510..534	CDD:290200	11/23 (48%)
		C2H2 Zn finger	526..546	CDD:275368	8/19 (42%)
		zf-H2C2_2	539..563	CDD:290200	14/23 (61%)
		C2H2 Zn finger	554..574	CDD:275368	8/19 (42%)
		C2H2 Zn finger	582..602	CDD:275368	6/19 (32%)
ZNF473	NP_001006657.1	KRAB_A-box	6..45	CDD:143639
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	47..81
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	140..164
		COG5048	207..614	CDD:227381	24/103 (23%)
		C2H2 Zn finger	211..231	CDD:275368
		C2H2 Zn finger	239..259	CDD:275368
		C2H2 Zn finger	267..286	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	290..318
		Interaction with SLBP/pre-mRNA complex	312..552		9/41 (22%)
		C2H2 Zn finger	322..342	CDD:275368
		C2H2 Zn finger	349..369	CDD:275368
		C2H2 Zn finger	377..397	CDD:275368
		C2H2 Zn finger	405..425	CDD:275368
		C2H2 Zn finger	433..453	CDD:275368
		COG5048	457..860	CDD:227381	110/329 (33%)
		C2H2 Zn finger	461..481	CDD:275368
		C2H2 Zn finger	489..509	CDD:275368
		C2H2 Zn finger	517..537	CDD:275368	4/19 (21%)
		C2H2 Zn finger	564..584	CDD:275368	8/19 (42%)
		C2H2 Zn finger	593..613	CDD:275368	4/19 (21%)
		C2H2 Zn finger	648..668	CDD:275368	7/19 (37%)
		C2H2 Zn finger	676..696	CDD:275368	8/19 (42%)
		C2H2 Zn finger	704..724	CDD:275368	6/19 (32%)
		C2H2 Zn finger	732..752	CDD:275368	7/19 (37%)
		C2H2 Zn finger	760..780	CDD:275368	8/19 (42%)
		C2H2 Zn finger	788..808	CDD:275368	8/19 (42%)
		C2H2 Zn finger	816..836	CDD:275368	6/19 (32%)
		C2H2 Zn finger	844..864	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910