DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and Zfp790

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001139352.1	Gene:	Zfp790 / 233056	MGIID:	1923431	Length:	779	Species:	Mus musculus

Alignment Length:	664	Identity:	167/664 - (25%)
Similarity:	238/664 - (35%)	Gaps:	159/664 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 DNLPEKVCLSCLSEISNCYTFKIKCENSSRTLRQLL----PNALP---EEPDSKVSIS------C 96
            |..||:  ..|||.........:..||.|..:...|    |:..|   :|.|:.:.:.      |
Mouse    13 DFSPEE--WECLSLDQKSLYRDVMLENYSHLVSVGLCIYQPHGFPVPEKEQDACMDLGNEPSRFC 75

  Fly    97 PVATTDQAVQTTSWEPDRCTASVQTDAVTTTDAEQNTSLIKSTISVD---LDYEGEGEVFDYELP 158
            |  .||     :.|:..:...:..|.|...:..|......|..::..   .|:||:|:
Mouse    76 P--DTD-----SRWQMKKALRTNSTCATRLSHWEGMGMEPKHGLAASCPAADWEGKGQ------- 126

  Fly   159 DEPVEKTTSLILQVQGNLKDEKEVVFTQTNVIYEGDDHELEQQIRECNLAIFEGVDNEAEIITVT 223
             ||.:.                           |..:..|:|....|        |....:..:|
Mouse   127 -EPPQS---------------------------ENQEETLQQMTLAC--------DKLPLLNLLT 155

  Fly   224 APQVTTRKSAAKLLTQQENDKHQTPVGSKEEARELEKEQVPQSAK----------RTSRRRGVVK 278
            |.|....|.|.|               :||...|......|:.|:          ...::||
Mouse   156 ALQCPRLKLAEK---------------TKEVKSEKSFSFAPEPAQLQLIHTGEKFEEDKKRG--- 202

  Fly   279 QDVPATPPSDAEPSPK--QHRLGTQRKLS-----APRAGTVNGPSTTSGAATTPELKYHCDRCNA 336
                .|.|    |.||  ::|.....|.:     ..:|.:.....|......|.|..:.|..|..
Mouse   203 ----KTFP----PGPKLTRYRAVQDGKKAFQCDECGKAFSFRSSLTGHKRIHTGEKPFTCKECGK 259

  Fly   337 GFAVEKSLMIH-RRQKGCINRNYKCNECEKVFVSPDHLAEHQASHGA---HNCPECGIRCDSKEA 397
            .|.....|.:| |...|  .::|:|..|.|.|.....|..|...|..   :.|.|||........
Mouse   260 AFRFHSLLSVHVRTHTG--EKSYECKACGKFFNYSSDLTRHHRIHTGEKPYQCRECGKAFSCGSD 322

  Fly   398 LSKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSFTQNANLRQHKLRH 462
            |::| .:.|......:||.|.|.|...|.|..|.||||||||:||..|||:||..:.|.||:..|
Mouse   323 LTRH-ERIHTGEKPYECNECGKAFIQQSHLIKHQRIHTGEKPYVCKECGKAFTCGSQLSQHRKIH 386

  Fly   463 SETKSFKCELCPHS----------------------------FVTKAELTSHARTHTGDKPFECE 499
            :..|..||:.|.:|                            |...||.......|||.|.:||:
Mouse   387 TGDKLHKCKECKNSFSFALDHTQRQLIYIGEKFFEDKENGETFFPGAEFPQCETVHTGKKLYECK 451

  Fly   500 VCLARFTTSCSLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQR 564
            .|...|:....::..|:.|..|:.:.|..|...|...:.|..|::.||||:||.|..|.|.|..|
Mouse   452 ECGKAFSLRSIVSSLKKIHNREKLFKCKDCEKAFRCPSDLSRHQKIHTGEKPYKCKECGKGFICR 516

  Fly   565 GDCQMHQRTHQGERIYICPVCNEEFKSMPEMRSHLAGHEQ-HDKRLVHF-----TFLSNKENGSG 623
            .|...|||.|.|.:.|:|..|.:.|    ...:||..|:: |.|:...|     .|.|..||...
Mouse   517 SDLGRHQRVHTGVKPYVCKECGKAF----TRGAHLTQHQKIHSKKSHEFNEGEKAFSSGLENTPH 577

  Fly   624 AL---EEELNEMTE 634
            :|   .|:|.|..|
Mouse   578 SLIPTGEKLWERKE 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071	9/33 (27%)
		C2H2 Zn finger	331..354	CDD:275368	7/23 (30%)
		COG5048	<357..570	CDD:227381	78/243 (32%)
		C2H2 Zn finger	360..380	CDD:275368	6/19 (32%)
		C2H2 Zn finger	385..406	CDD:275370	6/20 (30%)
		C2H2 Zn finger	414..434	CDD:275368	9/19 (47%)
		zf-H2C2_2	427..451	CDD:290200	16/23 (70%)
		C2H2 Zn finger	442..490	CDD:275368	18/75 (24%)
		C2H2 Zn finger	470..487	CDD:275368	6/44 (14%)
		zf-H2C2_2	482..507	CDD:290200	9/24 (38%)
		C2H2 Zn finger	498..518	CDD:275368	4/19 (21%)
		zf-H2C2_2	510..534	CDD:290200	5/23 (22%)
		C2H2 Zn finger	526..546	CDD:275368	5/19 (26%)
		zf-H2C2_2	539..563	CDD:290200	12/23 (52%)
		C2H2 Zn finger	554..574	CDD:275368	9/19 (47%)
		C2H2 Zn finger	582..602	CDD:275368	5/19 (26%)
Zfp790	NP_001139352.1	KRAB	5..61	CDD:214630	12/49 (24%)
		C2H2 Zn finger	202..218	CDD:275368	7/26 (27%)
		COG5048	224..686	CDD:227381	113/375 (30%)
		C2H2 Zn finger	226..246	CDD:275368	2/19 (11%)
		C2H2 Zn finger	254..274	CDD:275368	6/19 (32%)
		C2H2 Zn finger	282..302	CDD:275368	6/19 (32%)
		C2H2 Zn finger	310..330	CDD:275368	6/20 (30%)
		C2H2 Zn finger	338..358	CDD:275368	9/19 (47%)
		C2H2 Zn finger	366..386	CDD:275368	9/19 (47%)
		C2H2 Zn finger	450..470	CDD:275368	4/19 (21%)
		C2H2 Zn finger	478..498	CDD:275368	5/19 (26%)
		C2H2 Zn finger	506..526	CDD:275368	9/19 (47%)
		C2H2 Zn finger	534..554	CDD:275368	6/23 (26%)
		C2H2 Zn finger	614..634	CDD:275368
		C2H2 Zn finger	642..662	CDD:275368
		C2H2 Zn finger	670..690	CDD:275368
		zf-H2C2_2	682..707	CDD:404364
		C2H2 Zn finger	698..718	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000