DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6654 and ZNF510

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001300988.1	Gene:	ZNF510 / 22869	HGNCID:	29161	Length:	683	Species:	Homo sapiens

Alignment Length:	636	Identity:	168/636 - (26%)
Similarity:	255/636 - (40%)	Gaps:	178/636 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 DMIREFTKTKPRRNDNLPEKVCLSCLSEISNCYTFKIKCENSSRTLRQLLPNALPEEPDSKVSIS 95
            |:|::..|.|.:   :|.:.:|:                  :::||.......|.:.....|:
Human   124 DLIKQNKKIKDK---HLEQAICI------------------NNKTLTTEEEKVLGKPFTLHVA-- 165

  Fly    96 CPVATTDQAVQTTSWEPDRCTAS--------VQTDAVTTTDAEQNTSLIKSTISVDLDYEGEGEV 152
             .||:|..:.:..|||.:..:.|        ..|..:...:..:|     |...::.:....||.
Human   166 -AVASTKMSCKCNSWEVNLQSISEFIINNRNYSTKKIGCGNVCEN-----SPFKINFEKTQTGEK 224

  Fly   153 FDYE-------------LPDEPVEKTTSLILQVQGNLKDEKEVVFTQTNVIYEGDDHELEQQIRE 204
            | ||             ||..|..:|                                |||.. |
Human   225 F-YEHNKNMKALNYNENLPKHPKFQT--------------------------------LEQAF-E 255

  Fly   205 CNLAIFEGVDNEAEIITVTAPQVTTRKSAAKLLTQQENDKHQTPVGSKEEARELEKEQVPQSAKR 269
            || .|.:..:::|..:                   :.|..|.....||::  |..|    ...|:
Human   256 CN-KIGKAFNDKANCV-------------------KHNSSHTGETSSKDD--EFRK----NCDKK 294

  Fly   270 T---SRRRGVVKQDVPATPPSDA-------------------EPSPKQHRLGTQRKLSAPRAGTV 312
            |   .||.|..|:.:.......:                   |.:|..:....:..|:.|:...:
Human   295 TLFDHRRTGTGKKHLHLNQCGKSFEKSTVEEYNKLNMGIKHYELNPSGNNFNRKAHLTDPQTAVI 359

  Fly   313 NGPSTTSGAATTPELK----------------------------YHCDRCNAGFAVEKSLMIHRR 349
            ......|...|...:|                            |.|:.|...|..:..|:.|:|
Human   360 EENPLVSNDRTQTWVKSSEYHENKKSYQTSVHRVRRRSHSMMKPYKCNECGKSFCQKGHLIQHQR 424

  Fly   350 -QKGCINRNYKCNECEKVFVSPDHLAEHQASHGA---HNCPECGIRCDSKEALSKHMVQGHKR-- 408
             ..|  .:.::|:||.|.|....||:.||..|.|   :.|.|||     |..:.|..::||:|
Human   425 THTG--EKPFECSECGKTFSQKSHLSTHQRIHTAEKPYKCNECG-----KTFVQKSTLRGHQRIH 482

  Fly   409 --NLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSFTQNANLRQHKLRHSETKSFKCE 471
              ....:|:.|.|.|...||||||.|||||||.|.||.|||:|.|.:|||.|:..|:..|:::|.
Human   483 TGEKPYECSECGKTFVQKSTLRDHHRIHTGEKSFQCNQCGKTFGQKSNLRIHQRTHTGEKTYQCN 547

  Fly   472 LCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTSCSLAKHKRKHTGERPYACDLCPMRFTAL 536
            .|..||..|..|..|.:||||:|||:|..|...|..:.:|..|:|.||||:|:.|:.|..:|...
Human   548 ECEKSFWRKDHLIQHQKTHTGEKPFKCNECGKTFARTSTLRVHQRIHTGEKPFKCNECGKKFVRK 612

  Fly   537 NVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQGERIYICPVCNE 587
            .:|.:|:|.||||:|:.|..|.|||.|:.:.::|||||.||:.|   .|||
Human   613 AILSDHQRIHTGEKPFQCNKCGKTFGQKSNLRIHQRTHSGEKSY---ECNE 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071	8/47 (17%)
		C2H2 Zn finger	331..354	CDD:275368	7/23 (30%)
		COG5048	<357..570	CDD:227381	93/219 (42%)
		C2H2 Zn finger	360..380	CDD:275368	9/19 (47%)
		C2H2 Zn finger	385..406	CDD:275370	6/20 (30%)
		C2H2 Zn finger	414..434	CDD:275368	11/19 (58%)
		zf-H2C2_2	427..451	CDD:290200	18/23 (78%)
		C2H2 Zn finger	442..490	CDD:275368	20/47 (43%)
		C2H2 Zn finger	470..487	CDD:275368	6/16 (38%)
		zf-H2C2_2	482..507	CDD:290200	12/24 (50%)
		C2H2 Zn finger	498..518	CDD:275368	6/19 (32%)
		zf-H2C2_2	510..534	CDD:290200	10/23 (43%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		zf-H2C2_2	539..563	CDD:290200	13/23 (57%)
		C2H2 Zn finger	554..574	CDD:275368	9/19 (47%)
		C2H2 Zn finger	582..602	CDD:275368	3/6 (50%)
ZNF510	NP_001300988.1	KRAB	46..105	CDD:214630
		KRAB	46..85	CDD:279668
		COG5048	240..663	CDD:227381	143/490 (29%)
		C2H2 Zn finger	256..276	CDD:275368	5/39 (13%)
		zf-C2H2	404..426	CDD:278523	7/21 (33%)
		C2H2 Zn finger	406..426	CDD:275368	6/19 (32%)
		zf-H2C2_2	418..443	CDD:290200	9/26 (35%)
		C2H2 Zn finger	434..454	CDD:275368	9/19 (47%)
		zf-H2C2_2	446..471	CDD:290200	11/29 (38%)
		C2H2 Zn finger	462..482	CDD:275368	9/24 (38%)
		zf-H2C2_2	475..499	CDD:290200	7/23 (30%)
		C2H2 Zn finger	490..510	CDD:275368	11/19 (58%)
		zf-H2C2_2	503..525	CDD:290200	17/21 (81%)
		zf-C2H2	516..538	CDD:278523	12/21 (57%)
		C2H2 Zn finger	518..538	CDD:275368	11/19 (58%)
		zf-H2C2_2	530..555	CDD:290200	10/24 (42%)
		C2H2 Zn finger	546..566	CDD:275368	7/19 (37%)
		zf-H2C2_2	558..583	CDD:290200	12/24 (50%)
		C2H2 Zn finger	574..594	CDD:275368	6/19 (32%)
		zf-H2C2_2	587..611	CDD:290200	11/23 (48%)
		C2H2 Zn finger	602..622	CDD:275368	6/19 (32%)
		zf-H2C2_2	615..637	CDD:290200	11/21 (52%)
		zf-C2H2	628..650	CDD:278523	9/21 (43%)
		C2H2 Zn finger	630..650	CDD:275368	9/19 (47%)
		C2H2 Zn finger	658..676	CDD:275368	3/3 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910