DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6654 and ZNF652

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001138837.1	Gene:	ZNF652 / 22834	HGNCID:	29147	Length:	606	Species:	Homo sapiens

Alignment Length:	478	Identity:	130/478 - (27%)
Similarity:	207/478 - (43%)	Gaps:	97/478 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 YELPDEPVEKTTSLILQVQGNLKDEKEVVFTQTNVIYEGDDHELEQQ---------IRECNLAIF 210
            :|..::|..:.|..:..|.. :|:::|          ..||.|.|::         |.|.||
Human    73 HETEEQPYFRETRAVSDVHA-VKEDRE----------NSDDTEEEEEEVSYKREQIIVEVNL--- 123

  Fly   211 EGVDNEAEIITVTAPQVTTR-KSAAKLLTQQENDKHQT---------PVGSKEEARELEK--EQV 263
               :|:...::.....|::: |....|.|..|.::.::         ..|..|:.::.||  |:|
Human   124 ---NNQTLNVSKGEKGVSSQSKETPVLKTSSEEEEEESEEEATDDSNDYGENEKQKKKEKIVEKV 185

  Fly   264 PQSAKRTSRRRGVVKQDVPATPPS------DAEPSPKQHRLGTQRKLSAPRAGTVNGPSTTSGAA 322
            ..:.:||.|...|.......||.:      ..|| ||:.:..|:.    |:|.............
Human   186 SVTQRRTRRAASVAAATTSPTPRTTRGRRKSVEP-PKRKKRATKE----PKAPVQKAKCEEKETL 245

  Fly   323 TTPELKYHCDRC----NAGFAVEKSLMI-HRRQKGCINRNYKCNECEKVFVSPDHLAEHQASHGA 382
            |       |::|    |..:.:||.:.: |||.:       .|::|.|.||....|:.||.:
Human   246 T-------CEKCPRVFNTRWYLEKHMNVTHRRMQ-------ICDKCGKKFVLESELSLHQQT--- 293

  Fly   383 HNCPECGIRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTG--EKPFVCNIC 445
                :|                  ::|:  ||..|.|.|..|.:|.:|::|..|  ||.|.|.||
Human   294 ----DC------------------EKNI--QCVSCNKSFKKLWSLHEHIKIVHGYAEKKFSCEIC 334

  Fly   446 GKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTSCS 510
            .|.|...|::|:|.:.|::...|.||.|..||.....|..|:..|:|:|||.||.|..||.....
Human   335 EKKFYTMAHVRKHMVAHTKDMPFTCETCGKSFKRSMSLKVHSLQHSGEKPFRCENCDERFQYKYQ 399

  Fly   511 LAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQ 575
            |..|...|.|.:.:.|..|...|........|.:|||||:|::|..|.|:||.|.:.:.|:|||.
Human   400 LRSHMSIHIGHKQFMCQWCGKDFNMKQYFDEHMKTHTGEKPFICEICGKSFTSRPNMKRHRRTHT 464

  Fly   576 GERIYICPVCNEEFKSMPEMRSH 598
            ||:.|.|.||.:.|:....:::|
Human   465 GEKPYPCDVCGQRFRFSNMLKAH 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	8/27 (30%)
		COG5048	<357..570	CDD:227381	70/214 (33%)
		C2H2 Zn finger	360..380	CDD:275368	8/19 (42%)
		C2H2 Zn finger	385..406	CDD:275370	1/20 (5%)
		C2H2 Zn finger	414..434	CDD:275368	7/19 (37%)
		zf-H2C2_2	427..451	CDD:290200	12/25 (48%)
		C2H2 Zn finger	442..490	CDD:275368	17/47 (36%)
		C2H2 Zn finger	470..487	CDD:275368	6/16 (38%)
		zf-H2C2_2	482..507	CDD:290200	12/24 (50%)
		C2H2 Zn finger	498..518	CDD:275368	7/19 (37%)
		zf-H2C2_2	510..534	CDD:290200	6/23 (26%)
		C2H2 Zn finger	526..546	CDD:275368	4/19 (21%)
		zf-H2C2_2	539..563	CDD:290200	11/23 (48%)
		C2H2 Zn finger	554..574	CDD:275368	8/19 (42%)
		C2H2 Zn finger	582..602	CDD:275368	5/17 (29%)
ZNF652	NP_001138837.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	71..113		10/50 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	130..235		24/109 (22%)
		UFD1	<240..304	CDD:332114	21/104 (20%)
		C2H2 Zn finger	247..266	CDD:275368	5/18 (28%)
		C2H2 Zn finger	274..293	CDD:275368	8/18 (44%)
		C2H2 Zn finger	301..321	CDD:275368	7/19 (37%)
		C2H2 Zn finger	331..351	CDD:275368	8/19 (42%)
		C2H2 Zn finger	359..379	CDD:275368	7/19 (37%)
		SFP1	<381..464	CDD:227516	32/82 (39%)
		C2H2 Zn finger	387..407	CDD:275368	7/19 (37%)
		C2H2 Zn finger	415..435	CDD:275368	4/19 (21%)
		COG5048	439..>488	CDD:227381	19/49 (39%)
		C2H2 Zn finger	443..463	CDD:275368	8/19 (42%)
		C2H2 Zn finger	471..487	CDD:275368	4/15 (27%)
		Mediates interaction with CBFA2T3. /evidence=ECO:0000269\|PubMed:16966434	498..606
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149934
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930