DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6654 and ZUP1

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001348118.1	Gene:	ZUP1 / 221302	HGNCID:	21224	Length:	578	Species:	Homo sapiens

Alignment Length:	266	Identity:	56/266 - (21%)
Similarity:	93/266 - (34%)	Gaps:	83/266 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   442 CNICGKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAEL-----TSHARTHTGDKPFECEVC 501
            |||||::.|...:::.|.:.|.|::.. |..|..|.|...|:     |:|...:|.::.|| .:.
Human     4 CNICGETVTSEPDMKAHLIVHMESEII-CPFCKLSGVNYDEMCFHIETAHFEQNTLERNFE-RIN 66

  Fly   502 LARFTTS---------CSL-----------AKHKR------------KHTGERPYACDLCPMRFT 534
            ..::.||         |.:           :.|.:            ||.|.  |:.:|...|
Human    67 TVQYGTSDNKKDNTLQCGMEVNSSILSGCASNHPKNSAQNLTKDSTLKHEGF--YSENLTESR-- 127

  Fly   535 ALNVLKNHRRT-----------HTGERPYVCPFCSKTFTQRGDCQMHQRTHQG-----------E 577
              ..||:..:.           .|...|..||||.|......|.:.|.:|...           :
Human   128 --KFLKSREKQSSLTEIKGSVYETTYSPPECPFCGKIEEHSEDMETHVKTKHANLLDIPLEDCDQ 190

  Fly   578 RIYICPVCNEEFKSMPEMRSHLAGHEQH--------------DKRLVHFTFLSNKENGSGALEEE 628
            .:|.||:|.....:...::.|:..|.:.              |.:|.|  .|..:|:.....||.
Human   191 PLYDCPMCGLICTNYHILQEHVDLHLEENSFQQGMDRVQCSGDLQLAH--QLQQEEDRKRRSEES 253

  Fly   629 LNEMTE 634
            ..|:.|
Human   254 RQEIEE 259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368
		COG5048	<357..570	CDD:227381	39/175 (22%)
		C2H2 Zn finger	360..380	CDD:275368
		C2H2 Zn finger	385..406	CDD:275370
		C2H2 Zn finger	414..434	CDD:275368
		zf-H2C2_2	427..451	CDD:290200	5/8 (63%)
		C2H2 Zn finger	442..490	CDD:275368	16/52 (31%)
		C2H2 Zn finger	470..487	CDD:275368	6/21 (29%)
		zf-H2C2_2	482..507	CDD:290200	6/29 (21%)
		C2H2 Zn finger	498..518	CDD:275368	4/51 (8%)
		zf-H2C2_2	510..534	CDD:290200	7/46 (15%)
		C2H2 Zn finger	526..546	CDD:275368	4/30 (13%)
		zf-H2C2_2	539..563	CDD:290200	9/34 (26%)
		C2H2 Zn finger	554..574	CDD:275368	7/19 (37%)
		C2H2 Zn finger	582..602	CDD:275368	4/19 (21%)
ZUP1	NP_001348118.1	MIU. /evidence=ECO:0000305\|PubMed:29476094, ECO:0000305\|PubMed:29576527	226..248		5/23 (22%)
		zUBD/ZHA. /evidence=ECO:0000305\|PubMed:29476094, ECO:0000305\|PubMed:29576527	249..274		4/11 (36%)
		Peptidase_C78	336..551	CDD:311731
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149926
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930