DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZNF584

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_775819.1	Gene:	ZNF584 / 201514	HGNCID:	27318	Length:	421	Species:	Homo sapiens

Alignment Length:	403	Identity:	120/403 - (29%)
Similarity:	175/403 - (43%)	Gaps:	77/403 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   232 SAAKLLTQQENDKHQ--------TPVGSKEEAR---------ELEKEQV-PQSAKRTSRRRGVVK 278
            |.:.:.||.|:|:..        ||| |:.|||         .:|.|:. |:..|   ..|.:..
Human    61 SRSPVFTQLEDDEQSWVPSWVDVTPV-SRAEARRGFGLDGLCRVEDERAHPEHLK---SYRVIQH 121

  Fly   279 QDVPATPPSDAEPSPKQHRLGTQRKLSAPRAGTVNGPSTTSGAATTPELKYHCDRCNAGFAVEKS 343
            ||      :.:|..|::|                    |..|||..|           |.:..:.
Human   122 QD------THSEGKPRRH--------------------TEHGAAFPP-----------GSSCGQQ 149

  Fly   344 LMIHRRQKGCINRNYKCNECEKVFVSPDHLAEHQASHGAHNCPECGIRCDSKEALSKHMVQGHKR 408
            ..:|..:|     .:||::|.|||:....|.:|..:|.    .|...||.:..:..|.....:.|
Human   150 QEVHVAEK-----LFKCSDCGKVFLKAFALLDHLITHS----EERPFRCPTGRSAFKKSAHINPR 205

  Fly   409 NLR-----NQCNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSFTQNANLRQHKLRHSETKSF 468
            .:.     :.||.|.|.|:..|.||.|.::|||.|||.|:.|||:|.:...|..|:..|:..:.:
Human   206 KIHTGETAHVCNECGKAFSYPSKLRKHQKVHTGIKPFKCSDCGKTFNRKDALVLHQRIHTGERPY 270

  Fly   469 KCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTSCSLAKHKRKHTGERPYACDLCPMRF 533
            :|..|..:|...:.|..|.:.|.|::|:||..|...|..:.|...|:|.||||||:.|..|...:
Human   271 ECSKCGKTFSVLSTLIRHRKVHIGERPYECTECGKFFKYNNSFILHQRVHTGERPFECKQCGKGY 335

  Fly   534 TALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQGERIYICPVCNEEFKSMPEMRSH 598
            ...:.|..|.:.|||||||.|..|.||||.|.....||:.|..||.|.|..|.:.||....:..|
Human   336 VTRSGLYQHWKVHTGERPYECSLCGKTFTTRSYRNRHQQFHTEERSYECTECGKAFKHSSTLLQH 400

  Fly   599 LAGH----EQHDK 607
            ...|    .|.|:
Human   401 KKVHTPERRQEDR 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	3/22 (14%)
		COG5048	<357..570	CDD:227381	76/217 (35%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
		C2H2 Zn finger	385..406	CDD:275370	4/20 (20%)
		C2H2 Zn finger	414..434	CDD:275368	9/19 (47%)
		zf-H2C2_2	427..451	CDD:290200	14/23 (61%)
		C2H2 Zn finger	442..490	CDD:275368	13/47 (28%)
		C2H2 Zn finger	470..487	CDD:275368	4/16 (25%)
		zf-H2C2_2	482..507	CDD:290200	9/24 (38%)
		C2H2 Zn finger	498..518	CDD:275368	6/19 (32%)
		zf-H2C2_2	510..534	CDD:290200	11/23 (48%)
		C2H2 Zn finger	526..546	CDD:275368	4/19 (21%)
		zf-H2C2_2	539..563	CDD:290200	14/23 (61%)
		C2H2 Zn finger	554..574	CDD:275368	9/19 (47%)
		C2H2 Zn finger	582..602	CDD:275368	5/19 (26%)
ZNF584	NP_775819.1	KRAB	17..77	CDD:214630	5/15 (33%)
		KRAB	17..56	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..146		11/62 (18%)
		C2H2 Zn finger	161..181	CDD:275368	7/19 (37%)
		COG5048	<189..374	CDD:227381	66/184 (36%)
		zf-C2H2	214..236	CDD:278523	9/21 (43%)
		C2H2 Zn finger	216..236	CDD:275368	9/19 (47%)
		zf-H2C2_2	229..253	CDD:290200	14/23 (61%)
		C2H2 Zn finger	244..264	CDD:275368	7/19 (37%)
		zf-H2C2_2	256..280	CDD:290200	5/23 (22%)
		C2H2 Zn finger	272..292	CDD:275368	5/19 (26%)
		zf-H2C2_2	285..309	CDD:290200	9/23 (39%)
		C2H2 Zn finger	300..320	CDD:275368	6/19 (32%)
		zf-H2C2_2	316..337	CDD:290200	10/20 (50%)
		C2H2 Zn finger	328..348	CDD:275368	4/19 (21%)
		C2H2 Zn finger	356..376	CDD:275368	9/19 (47%)
		zf-H2C2_2	370..393	CDD:290200	9/22 (41%)
		C2H2 Zn finger	384..404	CDD:275368	5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	402..421		3/12 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910