DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6654 and Zfp483

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_596913.1	Gene:	Zfp483 / 170955	RGDID:	727958	Length:	733	Species:	Rattus norvegicus

Alignment Length:	699	Identity:	166/699 - (23%)
Similarity:	259/699 - (37%)	Gaps:	168/699 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 CYTFKIKCENSSRTLRQL------------------------------LPNAL-----PEEPDSK 91
            ||:.:   |...:||.||                              ||..:     .:.|:|.
  Rat    56 CYSQE---EGPRKTLNQLWELCKQWLRPDIHTKEQILELLVFEQFLRVLPGEMRIWVNSQHPESS 117

  Fly    92 VSISCPVATTDQAVQ----TTSWEPDRC-----------TASVQTDAVTTTDAEQNTSLIKSTIS 141
            |.:...|...:|.::    ..:..||.|           .|....:......||...::....:|
  Rat   118 VEVVTLVEDLNQTLEEKEDRNTQAPDVCKEEDLGEEAMAAAPPSAEVAAPPRAEPREAVTFEDVS 182

  Fly   142 VDLDYEGEGEVFD-----------------YELPDEPVEKTTSL----------ILQVQ------ 173
            ||.. .||.::.:                 .|:...||.|...:          :|:.:
  Rat   183 VDFT-RGEWKLLEPSQRELYKEVLLENLGSLEVLGSPVSKFDLISHLKWVKLPRVLEKELSKDPR 246

  Fly   174 -GNLKDEKEVVFTQTNVIYEGDDHELEQQIRECNLAIFEGVDNEAEIITVTAPQVTTRKSAAKLL 237
             |....|.|   :::.:....::..||:.:..|......|:..|.:                |.|
  Rat   247 PGESVKESE---SRSELDAFMEELTLEKTVEYCFSGGGYGLKTEFQ----------------KRL 292

  Fly   238 TQQENDKHQTPVGSKEEARELE---KEQVPQSAKRTSRRRGVV----KQDVPATPP--------- 286
            .:.|.|..:......:||...|   ::.|.|::.....|:.::    ::......|
  Rat   293 GKPEKDHGRRKSHESKEAESGETTSEKNVKQTSAMLKHRKALLTKTSQRSKEGKKPFSFHSALVN 357

  Fly   287 ------------SDAEPSPKQHRLGTQRKLSAPRAGTVNGPSTTS--GAATTPEL----KYHCDR 333
                        ||.|..|.:....|:|| ..|:.|::......|  |...|..|    ...|::
  Rat   358 RRELSGGKSRKCSDREKDPHRPLSPTERK-RHPKIGSLRKTEKCSKCGVDFTRILGCVESSQCEK 421

  Fly   334 CNAG-FAVEKSLMIHRRQKGCINRNYKCNECEKVF-------VSPDHLAEHQASHG--------- 381
            |... |..|.|   .:.|:.......||.:|.|..       |..:....|:||..
  Rat   422 CRKNLFQDETS---SKDQEADTEEPRKCKKCGKALEYGSKRSVCVECRNAHKASPSLKPQGKTDR 483

  Fly   382 ---AHNCPECGIRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCN 443
               ::.|.|||.|...:...|:|. :.|.|.....|..|.:.|:..|:...|.||||||||:.|.
  Rat   484 RKKSYKCDECGKRFAEENDFSQHQ-RTHTREKPYVCKHCGRAFSDNSSFCQHQRIHTGEKPYTCK 547

  Fly   444 ICGKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTS 508
            .||||||.:::|.:|:..|:..|.:||:.|..:|...:.||.|.:.|||:|||.|:.|...|...
  Rat   548 ECGKSFTHSSSLSKHQRIHTGEKPYKCKECGKAFRQNSCLTRHQKIHTGEKPFLCKECGLSFRLF 612

  Fly   509 CSLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRT 573
            .|:..|:|.|.||:||.|..|...|.:.:.|..|.|.|||.:||.|..|.|||.|.....:|.||
  Rat   613 SSIMYHQRLHKGEKPYKCPHCEKGFPSHSRLSRHLRIHTGAKPYKCKECGKTFRQSSSLNLHIRT 677

  Fly   574 HQGERIYICPVCNEEFKSMPEMRSHLAGHE--QHDKRLVHFTFLSNKEN 620
            |.||:.|.|..|...|.....:..|:..|.  ::|.:....:|.|...|
  Rat   678 HTGEKPYKCNYCGAAFTRSTILVEHVKTHTRVKYDCKKCGKSFKSRSAN 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071	5/16 (31%)
		C2H2 Zn finger	331..354	CDD:275368	6/23 (26%)
		COG5048	<357..570	CDD:227381	82/231 (35%)
		C2H2 Zn finger	360..380	CDD:275368	6/26 (23%)
		C2H2 Zn finger	385..406	CDD:275370	7/20 (35%)
		C2H2 Zn finger	414..434	CDD:275368	6/19 (32%)
		zf-H2C2_2	427..451	CDD:290200	15/23 (65%)
		C2H2 Zn finger	442..490	CDD:275368	18/47 (38%)
		C2H2 Zn finger	470..487	CDD:275368	5/16 (31%)
		zf-H2C2_2	482..507	CDD:290200	12/24 (50%)
		C2H2 Zn finger	498..518	CDD:275368	6/19 (32%)
		zf-H2C2_2	510..534	CDD:290200	10/23 (43%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		zf-H2C2_2	539..563	CDD:290200	13/23 (57%)
		C2H2 Zn finger	554..574	CDD:275368	8/19 (42%)
		C2H2 Zn finger	582..602	CDD:275368	4/19 (21%)
Zfp483	NP_596913.1	SCAN	46..127	CDD:396558	13/73 (18%)
		KRAB	176..229	CDD:214630	9/53 (17%)
		COG5048	<487..730	CDD:227381	90/241 (37%)
		C2H2 Zn finger	490..510	CDD:275368	7/20 (35%)
		C2H2 Zn finger	518..538	CDD:275368	6/19 (32%)
		C2H2 Zn finger	546..566	CDD:275368	9/19 (47%)
		C2H2 Zn finger	574..594	CDD:275368	6/19 (32%)
		C2H2 Zn finger	602..622	CDD:275368	6/19 (32%)
		C2H2 Zn finger	630..650	CDD:275368	6/19 (32%)
		C2H2 Zn finger	658..678	CDD:275368	8/19 (42%)
		C2H2 Zn finger	686..706	CDD:275368	4/19 (21%)
		C2H2 Zn finger	713..730	CDD:275368	3/14 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000