DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZNF780B

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	XP_005258647.1	Gene:	ZNF780B / 163131	HGNCID:	33109	Length:	834	Species:	Homo sapiens

Alignment Length:	475	Identity:	135/475 - (28%)
Similarity:	203/475 - (42%)	Gaps:	72/475 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 VDNEAEIITVTAPQVTTRKSAAKLLTQQENDKHQTPVGSKEEAR---ELEKEQVPQSAK------ 268
            ::|.:.:|::....:    |...::|..|.:|....|.|||.:|   :||.:..|:...
Human    36 LENYSHLISLAGSSI----SKPDVITLLEQEKEPWIVVSKETSRWYPDLESKYGPEKISPENDIF 96

  Fly   269 RTSRRRGVVKQDVPATP-------PSDAE-PSPKQHRLGTQRKLSAPRAGTVNG--------PST 317
            ..:..:.|:|| :..|.       .:|:| .|..:.|.|.|.       |.:|.        |:.
Human    97 EINLPKHVIKQ-ISKTLGLEAFYFRNDSEYRSRFEGRQGHQE-------GYINQKIISYEEMPAY 153

  Fly   318 TSGAATTPELK-YHCDRCNAGFAVEKSLM----IHRRQKGCINRNYKCNECEKVFVSPDHLAEHQ 377
            |..:......| |.|..|...|:...:|:    ||..:|     .|||.||.|.|.....|..||
Human   154 THASPIHNTHKPYECKECGKYFSCGSNLIQHQSIHTGEK-----PYKCKECGKAFQLHIQLTRHQ 213

  Fly   378 ASHGAH---NCPECGIRCDSKEALSKHMVQGHKRNLRN-----QCNICQKVFTMLSTLRDHMRIH 434
            ..|...   .|.|||...:....|::|      :|:..     :|..|.|.|...|.|..|..||
Human   214 KFHTGEKTFECKECGKAFNLPTQLNRH------KNIHTVKKLFECKECGKSFNRSSNLTQHQSIH 272

  Fly   435 TGEKPFVCNICGKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECE 499
            .|.||:.|..|||:|.:.:||.||:..||..|.|.|..|..:|....:|..|.|.|||:|||||:
Human   273 AGVKPYQCKECGKAFNRGSNLIQHQKIHSNEKPFVCRECEMAFRYHYQLIEHCRIHTGEKPFECK 337

  Fly   500 VCLARFTTSCSLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQR 564
            .|...||....|.:|::.|.||:|:.|..|...|:.||.|..|:..||||:|:.|..|.|:|.:.
Human   338 ECRKAFTLLTKLVRHQKIHMGEKPFECRECGKAFSLLNQLNRHKNIHTGEKPFECKECGKSFNRS 402

  Fly   565 GDCQMHQRTHQGERIYICPVCNEEFKSMPEMRSHLAGHEQHDKRLV----------HFTFLSNKE 619
            .:...||..|...:.|.|..|.:.|.....:..|...| .::|..|          |:..:.:.:
Human   403 SNLIQHQSIHADVKPYECKECGKGFNRGANLIQHQKIH-SNEKPFVCRECEMAFRYHYQLIQHCQ 466

  Fly   620 NGSGALEEELNEMTESALML 639
            ..:|....|..|..::..:|
Human   467 IHTGGKPFECKECGKAFSLL 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	7/26 (27%)
		COG5048	<357..570	CDD:227381	82/220 (37%)
		C2H2 Zn finger	360..380	CDD:275368	8/19 (42%)
		C2H2 Zn finger	385..406	CDD:275370	6/20 (30%)
		C2H2 Zn finger	414..434	CDD:275368	7/19 (37%)
		zf-H2C2_2	427..451	CDD:290200	12/23 (52%)
		C2H2 Zn finger	442..490	CDD:275368	19/47 (40%)
		C2H2 Zn finger	470..487	CDD:275368	4/16 (25%)
		zf-H2C2_2	482..507	CDD:290200	13/24 (54%)
		C2H2 Zn finger	498..518	CDD:275368	6/19 (32%)
		zf-H2C2_2	510..534	CDD:290200	8/23 (35%)
		C2H2 Zn finger	526..546	CDD:275368	7/19 (37%)
		zf-H2C2_2	539..563	CDD:290200	11/23 (48%)
		C2H2 Zn finger	554..574	CDD:275368	6/19 (32%)
		C2H2 Zn finger	582..602	CDD:275368	4/19 (21%)
ZNF780B	XP_005258647.1	KRAB	6..67	CDD:214630	6/34 (18%)
		KRAB	6..45	CDD:279668	2/8 (25%)
		C2H2 Zn finger	168..188	CDD:275368	4/19 (21%)
		zf-H2C2_2	180..203	CDD:290200	10/27 (37%)
		COG5048	192..633	CDD:227381	99/307 (32%)
		C2H2 Zn finger	196..216	CDD:275368	8/19 (42%)
		zf-H2C2_2	209..232	CDD:290200	8/22 (36%)
		C2H2 Zn finger	224..244	CDD:275368	7/25 (28%)
		C2H2 Zn finger	252..272	CDD:275368	7/19 (37%)
		C2H2 Zn finger	280..300	CDD:275368	9/19 (47%)
		C2H2 Zn finger	308..328	CDD:275368	6/19 (32%)
		zf-H2C2_2	321..344	CDD:290200	12/22 (55%)
		C2H2 Zn finger	336..356	CDD:275368	6/19 (32%)
		zf-H2C2_2	349..372	CDD:290200	8/22 (36%)
		C2H2 Zn finger	364..384	CDD:275368	7/19 (37%)
		zf-H2C2_2	377..401	CDD:290200	11/23 (48%)
		C2H2 Zn finger	392..412	CDD:275368	6/19 (32%)
		C2H2 Zn finger	420..440	CDD:275368	4/19 (21%)
		C2H2 Zn finger	448..468	CDD:275368	1/19 (5%)
		C2H2 Zn finger	476..496	CDD:275368	2/11 (18%)
		zf-H2C2_2	489..513	CDD:290200
		C2H2 Zn finger	504..524	CDD:275368
		zf-H2C2_2	516..539	CDD:290200
		C2H2 Zn finger	532..552	CDD:275368
		zf-H2C2_2	545..569	CDD:290200
		C2H2 Zn finger	560..580	CDD:275368
		zf-H2C2_2	572..595	CDD:290200
		C2H2 Zn finger	588..608	CDD:275368
		zf-H2C2_2	600..624	CDD:290200
		C2H2 Zn finger	616..636	CDD:275368
		COG5048	624..>700	CDD:227381
		zf-H2C2_2	629..653	CDD:290200
		C2H2 Zn finger	644..664	CDD:275368
		C2H2 Zn finger	672..692	CDD:275368
		C2H2 Zn finger	700..720	CDD:275368
		zf-H2C2_2	713..735	CDD:290200
		C2H2 Zn finger	728..748	CDD:275368
		zf-H2C2_2	741..765	CDD:290200
		C2H2 Zn finger	756..776	CDD:275368
		C2H2 Zn finger	784..803	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000