DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZNF567

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001374688.1	Gene:	ZNF567 / 163081	HGNCID:	28696	Length:	670	Species:	Homo sapiens

Alignment Length:	425	Identity:	130/425 - (30%)
Similarity:	193/425 - (45%)	Gaps:	40/425 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 DNEAEIITVTAPQVTTRKSAAKLLTQQENDKHQTPVGSKEEARELEKEQVPQSAKRTSRRRGVVK 278
            |....|:...:..:.:..:.|:....:.|...::.:.:|:|....|.:...|||:..|....:::
Human   158 DTHGRILKNVSELIISNLNPARKRLSEYNGYGKSLLSTKQETTHPEVKSHNQSARAFSHNEVLMQ 222

  Fly   279 QDVPATPP-----SDAEPSPKQHRLGTQRKLSAPRAGTVNGPSTTSGAATTPELKYHCDRCNAGF 338
            .....||.     :|.|.|..|.  |.....|.|..|...........||..|.|:.|:.|...|
Human   223 YQKTETPAQSFGYNDCEKSFLQR--GGLITHSRPYKGENPSVYNKKRRATNIEKKHTCNECGKSF 285

  Fly   339 AVEKSLMIHR------------------RQKGCI---------NRNYKCNECEKVFVSPDHLAEH 376
            ..:..|::|:                  |:|..:         .:.:.||||.|.|.....|.:|
Human   286 CRKSVLILHQGIHSEEKPYQCHQCGNAFRRKSYLIDHQRTHTGEKPFVCNECGKSFRLKTALTDH 350

  Fly   377 QASHGAHNCPECGIRCDSKEALSKHMVQGHKRNLRN----QCNICQKVFTMLSTLRDHMRIHTGE 437
            |.:|......|| ::|.:...|..|::: |:|....    :||.|.|.|...:||..|.||||||
Human   351 QRTHTGEKSYEC-LQCRNAFRLKSHLIR-HQRTHTGEKPYECNDCGKSFRQKTTLSLHQRIHTGE 413

  Fly   438 KPFVCNICGKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCL 502
            ||::|..|||||.|.|||..|:..|:..|.:.|..|..||..|..|..|.:||..:||:.|..|.
Human   414 KPYICKECGKSFHQKANLTVHQRTHTGEKPYICNECGKSFSQKTTLALHEKTHNEEKPYICSECG 478

  Fly   503 ARFTTSCSLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDC 567
            ..|....:|..|:|.||||:.|.|..|...|...:.|.:|.||||||:||.|..|.|:|:|:.:.
Human   479 KSFRQKTTLVAHQRTHTGEKSYECPHCGKAFRMKSYLIDHHRTHTGEKPYECNECGKSFSQKTNL 543

  Fly   568 QMHQRTHQGERIYICPVCNEEFKSMPEMRSHLAGH 602
            .:|||.|.||:.|:|..|.:.|:....:..|...|
Human   544 NLHQRIHTGEKPYVCNECGKSFRQKATLTVHQKIH 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	7/40 (18%)
		COG5048	<357..570	CDD:227381	86/216 (40%)
		C2H2 Zn finger	360..380	CDD:275368	9/19 (47%)
		C2H2 Zn finger	385..406	CDD:275370	5/20 (25%)
		C2H2 Zn finger	414..434	CDD:275368	9/19 (47%)
		zf-H2C2_2	427..451	CDD:290200	16/23 (70%)
		C2H2 Zn finger	442..490	CDD:275368	20/47 (43%)
		C2H2 Zn finger	470..487	CDD:275368	6/16 (38%)
		zf-H2C2_2	482..507	CDD:290200	9/24 (38%)
		C2H2 Zn finger	498..518	CDD:275368	6/19 (32%)
		zf-H2C2_2	510..534	CDD:290200	10/23 (43%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		zf-H2C2_2	539..563	CDD:290200	14/23 (61%)
		C2H2 Zn finger	554..574	CDD:275368	8/19 (42%)
		C2H2 Zn finger	582..602	CDD:275368	4/19 (21%)
ZNF567	NP_001374688.1	KRAB	6..89	CDD:214630
		C2H2 Zn finger	236..255	CDD:275368	6/20 (30%)
		C2H2 Zn finger	278..298	CDD:275368	5/19 (26%)
		COG5048	302..650	CDD:227381	100/279 (36%)
		C2H2 Zn finger	306..326	CDD:275368	2/19 (11%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		C2H2 Zn finger	362..382	CDD:275368	6/21 (29%)
		C2H2 Zn finger	390..410	CDD:275368	9/19 (47%)
		C2H2 Zn finger	418..438	CDD:275368	11/19 (58%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..494	CDD:275368	6/19 (32%)
		C2H2 Zn finger	502..522	CDD:275368	6/19 (32%)
		C2H2 Zn finger	530..550	CDD:275368	8/19 (42%)
		C2H2 Zn finger	558..578	CDD:275368	4/19 (21%)
		C2H2 Zn finger	586..606	CDD:275368
		C2H2 Zn finger	614..634	CDD:275368
		zf-C2H2	640..662	CDD:395048
		C2H2 Zn finger	642..662	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910