DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6654 and ZNF600

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001308795.1	Gene:	ZNF600 / 162966	HGNCID:	30951	Length:	791	Species:	Homo sapiens

Alignment Length:	584	Identity:	159/584 - (27%)
Similarity:	231/584 - (39%)	Gaps:	138/584 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 DLDYE-GEGEVFDYELPDEPVEKTTSLILQVQ----GN--LKDEKEVVFTQTNVIYEGDDHELEQ 200
            |:::: .|.|...:|.|...::|.|....|..    ||  :||:....|              ..
Human   112 DIEFQCQEDERNGHEAPMTKIKKLTGSTDQHDHRHAGNKPIKDQLGSSF--------------YS 162

  Fly   201 QIRECNLAIFEG-VDNEAEIITVTAPQVTT--RKSAAKLLTQQENDKHQTPVGS----KEEAREL 258
            .:.|.::...:| :.|:.|..|..||.|:|  |.|....:....|..:.:|..|    |:|....
Human   163 HLPELHIIQIKGKIGNQFEKSTSDAPSVSTSQRISPRPQIHISNNYGNNSPNSSLLPQKQEVYMR 227

  Fly   259 EKE-QVPQSAKRTSRRRGVVKQDVPATPPSDAEPSPKQHRLGTQRKLSAPRAGTVNGPSTTSGAA 322
            ||. |..:|.|..:....:.|..:|       ....||::.....||...:...     |.....
Human   228 EKSFQCNESGKAFNCSSLLRKHQIP-------HLGDKQYKCDVCGKLFNHKQYL-----TCHCRC 280

  Fly   323 TTPELKYHCDRCNAGFAVEKSLMIHRRQKGCINRNYKCNECEKVFVSPDHLAEHQASHGA---HN 384
            .|.|..|.|:.|...|:...||..|||....: :::|||||.|:|.....|..|:|.|..   :.
Human   281 HTGEKPYKCNECGKSFSQVSSLTCHRRLHTAV-KSHKCNECGKIFGQNSALVIHKAIHTGEKPYK 344

  Fly   385 CPECGIRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSF 449
            |.||....:.:..|::|. :.|......:|..|.|||:..|||..|.||||||||:.|.:|..:|
Human   345 CNECDKAFNQQSNLARHR-RIHTGEKPYKCEECDKVFSRKSTLESHKRIHTGEKPYKCKVCDTAF 408

  Fly   450 TQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHAR-------------------------- 488
            |.|:.|.:||..|:..|::||..|..:|..|:.|..|.|
Human   409 TWNSQLARHKRIHTGEKTYKCNECGKTFSHKSSLVCHHRLHGGEKSYKCKVCDKAFAWNSHLVRH 473

  Fly   489 ----------------------------------------------------------THTGDKP 495
                                                                      .|||:||
Human   474 TRIHSGGKPYKCNECGKTFGQNSDLLIHKSIHTGEQPYKYEECEKVFSCGSTLETHKIIHTGEKP 538

  Fly   496 FECEVCLARFTTSCSLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKT 560
            ::|:||...|.....||||.|.|:||:||.|:.|...|...:.|.:|||.|:||:||.|..||||
Human   539 YKCKVCDKAFACHSYLAKHTRIHSGEKPYKCNECSKTFRLRSYLASHRRVHSGEKPYKCNECSKT 603

  Fly   561 FTQRGDCQMHQRTHQGERIYICPVCNEEFKSMPEMRSHLAGHEQH--------DKRLVHFTFLS 616
            |:||.....|:|.|.||:.|.|..|.:.|...|.:..|...|...        ||..|..::|:
Human   604 FSQRSYLHCHRRLHSGEKPYKCNECGKTFSHKPSLVHHRRLHTGEKSYKCTVCDKAFVRNSYLA 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	8/22 (36%)
		COG5048	<357..570	CDD:227381	91/299 (30%)
		C2H2 Zn finger	360..380	CDD:275368	9/19 (47%)
		C2H2 Zn finger	385..406	CDD:275370	5/20 (25%)
		C2H2 Zn finger	414..434	CDD:275368	10/19 (53%)
		zf-H2C2_2	427..451	CDD:290200	13/23 (57%)
		C2H2 Zn finger	442..490	CDD:275368	18/131 (14%)
		C2H2 Zn finger	470..487	CDD:275368	5/16 (31%)
		zf-H2C2_2	482..507	CDD:290200	12/108 (11%)
		C2H2 Zn finger	498..518	CDD:275368	9/19 (47%)
		zf-H2C2_2	510..534	CDD:290200	12/23 (52%)
		C2H2 Zn finger	526..546	CDD:275368	7/19 (37%)
		zf-H2C2_2	539..563	CDD:290200	15/23 (65%)
		C2H2 Zn finger	554..574	CDD:275368	10/19 (53%)
		C2H2 Zn finger	582..602	CDD:275368	5/19 (26%)
ZNF600	NP_001308795.1	KRAB	24..71	CDD:214630
		KRAB	24..60	CDD:279668
		COG5048	<154..503	CDD:227381	93/376 (25%)
		C2H2 Zn finger	233..253	CDD:275368	4/26 (15%)
		C2H2 Zn finger	261..281	CDD:275368	3/24 (13%)
		zf-H2C2_2	273..298	CDD:290200	7/29 (24%)
		C2H2 Zn finger	289..309	CDD:275368	8/19 (42%)
		C2H2 Zn finger	317..337	CDD:275368	9/19 (47%)
		zf-H2C2_2	329..354	CDD:290200	7/24 (29%)
		COG5048	341..748	CDD:227381	96/328 (29%)
		C2H2 Zn finger	345..365	CDD:275368	5/20 (25%)
		zf-H2C2_2	357..382	CDD:290200	8/25 (32%)
		C2H2 Zn finger	373..393	CDD:275368	10/19 (53%)
		zf-H2C2_2	386..409	CDD:290200	12/22 (55%)
		C2H2 Zn finger	401..421	CDD:275368	8/19 (42%)
		zf-H2C2_2	414..438	CDD:290200	9/23 (39%)
		C2H2 Zn finger	429..449	CDD:275368	7/19 (37%)
		C2H2 Zn finger	457..477	CDD:275368	0/19 (0%)
		C2H2 Zn finger	485..505	CDD:275368	0/19 (0%)
		C2H2 Zn finger	513..533	CDD:275368	0/19 (0%)
		zf-H2C2_2	526..550	CDD:290200	9/23 (39%)
		C2H2 Zn finger	541..561	CDD:275368	9/19 (47%)
		C2H2 Zn finger	569..589	CDD:275368	7/19 (37%)
		zf-H2C2_2	581..606	CDD:290200	15/24 (63%)
		C2H2 Zn finger	597..617	CDD:275368	10/19 (53%)
		C2H2 Zn finger	625..645	CDD:275368	5/19 (26%)
		C2H2 Zn finger	653..673	CDD:275368	4/15 (27%)
		zf-H2C2_2	665..690	CDD:290200	1/3 (33%)
		C2H2 Zn finger	681..701	CDD:275368
		zf-C2H2	707..729	CDD:278523
		C2H2 Zn finger	709..729	CDD:275368
		zf-H2C2_2	721..744	CDD:290200
		C2H2 Zn finger	737..757	CDD:275368
		zf-H2C2_2	749..773	CDD:290200
		C2H2 Zn finger	765..785	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910