DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6654 and ZNF782

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001001662.1	Gene:	ZNF782 / 158431	HGNCID:	33110	Length:	699	Species:	Homo sapiens

Alignment Length:	537	Identity:	157/537 - (29%)
Similarity:	228/537 - (42%)	Gaps:	100/537 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 QTDAVTTTDAEQNTS----LIKSTISVDLDYEGEGEVFDY-ELPDEPVEKTTSLILQVQGNLKDE 179
            ||......|.|.|.|    |.|:.:........:|:.::: :..:...:|:|.:|.|   |:..|
Human   206 QTIQTLGQDFEYNESRKAFLEKAALVTSNSTHPKGKSYNFNKFGENKYDKSTFIIPQ---NMNPE 267

  Fly   180 K-EVVFTQTNVIYEGDDHELEQQIRECNLAIFEGVDNEAEIITVTAPQVTTRKSAAKLLTQQEND 243
            | ...|..|...:....|:                       |:|..:..::||..:       :
Human   268 KSHYEFNDTGNCFCRITHK-----------------------TLTGGKSFSQKSHIR-------E 302

  Fly   244 KHQTPVGSKEEARELEKEQVPQSAKRTSRRRGV--VKQDVPATPP-SDAEPSPK----QHRLGTQ 301
            .|:..:|.|           |....::..|...  |.|...||.. ||..|..:    |......
Human   303 HHRVHIGVK-----------PFEYGKSFNRNSTLPVHQRTHATDKYSDYHPCTETFSYQSTFSVH 356

  Fly   302 RKL---SAPRAGTVNGPSTTSGA-------ATTPELKYHCDRCNAGFAVEKSLMIHRR-QKGCIN 355
            :|:   :.|......|.|.:..:       :.|.|..|.|..|...|:.:..|..|:| ..|  .
Human   357 QKVHIRAKPYEYNECGKSCSMNSHLIWPQKSHTGEKPYECPECGKAFSEKSRLRKHQRTHTG--E 419

  Fly   356 RNYKCNECEKVFVSPDHLAEHQASHGAH---NCPECGIRCDSKEALSKHMVQ------------- 404
            :.|||:.|:|.|.:...|..||.:|...   .|.|||...:.|..|..|...
Human   420 KPYKCDGCDKAFSAKSGLRIHQRTHTGEKPFECHECGKSFNYKSILIVHQRTHTGEKPFECNECG 484

  Fly   405 ---GHKRNLRN-----------QCNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSFTQNANL 455
               .|...|||           :|:.|.|.|.:.|.||.|.|.||||||:.||.|||:|.|.:.|
Human   485 KSFSHMSGLRNHRRTHTGERPYKCDECGKAFKLKSGLRKHHRTHTGEKPYKCNQCGKAFGQKSQL 549

  Fly   456 RQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTSCSLAKHKRKHTG 520
            |.|...|:..|.:||..|..:|..|:.|..|.|||||:||::||.|...|....:|..|:|.|||
Human   550 RGHHRIHTGEKPYKCNHCGEAFSQKSNLRVHHRTHTGEKPYQCEECGKTFRQKSNLRGHQRTHTG 614

  Fly   521 ERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQGERIYICPVC 585
            |:||.|:.|...|:..:||:.|:||||||:||.|..|.:.|:|:.:.::|||||.||:.|.|..|
Human   615 EKPYECNECGKAFSEKSVLRKHQRTHTGEKPYNCNQCGEAFSQKSNLRVHQRTHTGEKPYKCDKC 679

  Fly   586 NEEFKSMPEMRSHLAGH 602
            ...|.....:|.|...|
Human   680 GRTFSQKSSLREHQKAH 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	7/23 (30%)
		COG5048	<357..570	CDD:227381	93/242 (38%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
		C2H2 Zn finger	385..406	CDD:275370	7/36 (19%)
		C2H2 Zn finger	414..434	CDD:275368	9/19 (47%)
		zf-H2C2_2	427..451	CDD:290200	16/23 (70%)
		C2H2 Zn finger	442..490	CDD:275368	20/47 (43%)
		C2H2 Zn finger	470..487	CDD:275368	5/16 (31%)
		zf-H2C2_2	482..507	CDD:290200	13/24 (54%)
		C2H2 Zn finger	498..518	CDD:275368	7/19 (37%)
		zf-H2C2_2	510..534	CDD:290200	11/23 (48%)
		C2H2 Zn finger	526..546	CDD:275368	7/19 (37%)
		zf-H2C2_2	539..563	CDD:290200	13/23 (57%)
		C2H2 Zn finger	554..574	CDD:275368	7/19 (37%)
		C2H2 Zn finger	582..602	CDD:275368	5/19 (26%)
ZNF782	NP_001001662.1	KRAB	8..67	CDD:214630
		KRAB	8..47	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..95
		C2H2 Zn finger	291..307	CDD:275368	3/22 (14%)
		C2H2 Zn finger	314..332	CDD:275368	3/17 (18%)
		C2H2 Zn finger	343..360	CDD:275368	2/16 (13%)
		C2H2 Zn finger	369..388	CDD:275368	2/18 (11%)
		COG5048	392..697	CDD:227381	115/307 (37%)
		C2H2 Zn finger	396..416	CDD:275368	6/19 (32%)
		zf-H2C2_2	409..432	CDD:290200	9/24 (38%)
		C2H2 Zn finger	424..444	CDD:275368	7/19 (37%)
		zf-H2C2_2	437..461	CDD:290200	8/23 (35%)
		C2H2 Zn finger	452..472	CDD:275368	7/19 (37%)
		zf-H2C2_2	465..489	CDD:290200	2/23 (9%)
		C2H2 Zn finger	480..500	CDD:275368	4/19 (21%)
		zf-H2C2_2	493..516	CDD:290200	6/22 (27%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		zf-H2C2_2	521..543	CDD:290200	15/21 (71%)
		C2H2 Zn finger	536..556	CDD:275368	10/19 (53%)
		zf-H2C2_2	549..573	CDD:290200	9/23 (39%)
		C2H2 Zn finger	564..584	CDD:275368	7/19 (37%)
		zf-H2C2_2	576..601	CDD:290200	13/24 (54%)
		C2H2 Zn finger	592..612	CDD:275368	7/19 (37%)
		zf-H2C2_2	604..628	CDD:290200	11/23 (48%)
		C2H2 Zn finger	620..640	CDD:275368	7/19 (37%)
		zf-H2C2_2	633..657	CDD:290200	13/23 (57%)
		C2H2 Zn finger	648..668	CDD:275368	7/19 (37%)
		zf-H2C2_2	660..685	CDD:290200	11/24 (46%)
		C2H2 Zn finger	676..696	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910