DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6654 and ZNF746

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001381127.1	Gene:	ZNF746 / 155061	HGNCID:	21948	Length:	660	Species:	Homo sapiens

Alignment Length:	683	Identity:	147/683 - (21%)
Similarity:	218/683 - (31%)	Gaps:	224/683 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 SISCPV-----ATTDQAVQTTSWEPDRCTASVQTDAVTTTDAEQNTSLIKSTISVDLDYEGEGEV 152
            :::.|:     |.|.||::          ..:::.|......|..|.:.:..::   |.|.....
Human     4 AVAAPISPWTMAATIQAME----------RKIESQAARLLSLEGRTGMAEKKLA---DCEKTAVE 55

  Fly   153 FDYELPDEPVEKTTSLILQVQGNLKDEKEVVFTQTNVIYEGDDHELEQQIRECNLAIFE---GVD 214
            |..:|  |........:||..|.|:...|               .:|..:|..|..|..   |..
Human    56 FGNQL--EGKWAVLGTLLQEYGLLQRRLE---------------NVENLLRNRNFWILRLPPGSK 103

  Fly   215 NEAEIITVTAPQVT---TRKSAAKLLT-QQENDKH------QTPVG-----SKEEA-RELEKEQV 263
            .|:..:.||...|.   :.:...||.. |:|..||      :|.|.     ||.|. .::|:.:.
Human   104 GESPKVPVTFDDVAVYFSEQEWGKLEDWQKELYKHVMRGNYETLVSLDYAISKPEVLSQIEQGKE 168

  Fly   264 PQSAKRTSRRRGVVKQDVPATP-PSDAEPSP-----------------KQHRLGTQRKLSA---- 306
            |.:    .||.|....|||..| |....|.|                 :|..||.:...:.
Human   169 PCN----WRRPGPKIPDVPVDPSPGSGPPVPAPDLLMQIKQEGELQLQEQQALGVEAWAAGQPDI 229

  Fly   307 -----------PRAGTVNGPSTTSG-----AATTPELKYHCDRCNAGFAVEKSLMIHRRQKGCIN 355
                       ..||.:: ...|||     :.|.|...:..|           |..|.....|.:
Human   230 GEEPWGLSQLDSGAGDIS-TDATSGVHSNFSTTIPPTSWQTD-----------LPPHHPSSACSD 282

  Fly   356 RNYKCNEC-----------------EKVFVSPDHLAEHQASHGA--------------------- 382
            ...|.|..                 |:|..:|.|..:.:| ||.
Human   283 GTLKLNTAASTEADVKIVIKTEVQEEEVVATPVHPTDLEA-HGTLFGPGQATRFFPSPAQEGAWE 346

  Fly   383 -------HNCPECGIRCDSKE-----ALSKHMVQ----------GHKR---NLRNQCNICQKVFT 422
                   ...|..|:|..::.     .||..:.|          |..|   |.|.:..:.....|
Human   347 SQGSSFPSQDPVLGLREPARPERDMGELSPAVAQEETPPGDWLFGGVRWGWNFRCKPPVGLNPRT 411

  Fly   423 MLSTLRDHMRIHTGE---------KPF--VCNICG--KSFTQNANLRQHKLRHSETKSFKCELCP 474
            ....| .:.....||         :||  .|...|  |.|.....|::|.......:.|.|..|.
Human   412 GPEGL-PYSSPDNGEAILDPSQAPRPFNEPCKYPGRTKGFGHKPGLKKHPAAPPGGRPFTCATCG 475

  Fly   475 HSFVTKAELTSHART---HTGDKP--------------------------FECEVCLARFTTSCS 510
            .||..:..|::|.|:   ..|..|                          ..|..|...||....
Human   476 KSFQLQVSLSAHQRSCGAPDGSGPGTGGGGSGSGGGGGGSGGGSARDGSALRCGECGRCFTRPAH 540

  Fly   511 LAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTH- 574
            |.:|:..||||||:.|..|..|||..:.|.:|.|||||.||:.|..|.|:|.::...:.|||.|
Human   541 LIRHRMLHTGERPFPCTECEKRFTERSKLIDHYRTHTGVRPFTCTVCGKSFIRKDHLRKHQRNHA 605

  Fly   575 -------QGERIYICPVCNEEFKSMPEMRSHLA 600
                   :|:.:...|...:.||| |..:..||
Human   606 AGAKTPARGQPLPTPPAPPDPFKS-PASKGPLA 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	3/22 (14%)
		COG5048	<357..570	CDD:227381	71/317 (22%)
		C2H2 Zn finger	360..380	CDD:275368	6/36 (17%)
		C2H2 Zn finger	385..406	CDD:275370	6/35 (17%)
		C2H2 Zn finger	414..434	CDD:275368	2/19 (11%)
		zf-H2C2_2	427..451	CDD:290200	9/36 (25%)
		C2H2 Zn finger	442..490	CDD:275368	14/52 (27%)
		C2H2 Zn finger	470..487	CDD:275368	5/16 (31%)
		zf-H2C2_2	482..507	CDD:290200	8/53 (15%)
		C2H2 Zn finger	498..518	CDD:275368	6/19 (32%)
		zf-H2C2_2	510..534	CDD:290200	11/23 (48%)
		C2H2 Zn finger	526..546	CDD:275368	8/19 (42%)
		zf-H2C2_2	539..563	CDD:290200	13/23 (57%)
		C2H2 Zn finger	554..574	CDD:275368	7/19 (37%)
		C2H2 Zn finger	582..602	CDD:275368	7/19 (37%)
ZNF746	NP_001381127.1	DUF3669	25..81	CDD:403575	12/60 (20%)
		KRAB	111..171	CDD:214630	16/59 (27%)
		zf-C2H2_11	522..548	CDD:406917	6/25 (24%)
		C2H2 Zn finger	528..548	CDD:275368	6/19 (32%)
		zf-H2C2_2	540..564	CDD:404364	11/23 (48%)
		C2H2 Zn finger	556..576	CDD:275368	8/19 (42%)
		zf-H2C2_2	569..593	CDD:404364	13/23 (57%)
		zf-C2H2	582..604	CDD:395048	7/21 (33%)
		C2H2 Zn finger	584..604	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100