DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZNF570

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001287922.1	Gene:	ZNF570 / 148268	HGNCID:	26416	Length:	592	Species:	Homo sapiens

Alignment Length:	504	Identity:	143/504 - (28%)
Similarity:	216/504 - (42%)	Gaps:	105/504 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 TSWEPDRCTASVQTDAVTTTDAEQNTSLIKSTISVDLDYEGEGEVFDYELPDEPVEKTTSLILQV 172
            :.||| .|.....|......:..|:..:|::..|.:|:|....|.:          |......:.
Human   141 SGWEP-ICETEELTPKQDFYEEHQSQKIIETLTSYNLEYSSLREEW----------KCEGYFERQ 194

  Fly   173 QGNLKDEKEVVFTQTNVIYEGDDHELEQQIRECNLAIFEGVDNEAEIITVTAPQVTTRKSAAKLL 237
            .||.|                              |.|     :.||||...|....|:...|
Human   195 PGNQK------------------------------ACF-----KEEIITHEEPLFDEREQEYK-- 222

  Fly   238 TQQENDKHQTPVGSKEEARELEKEQVPQSAKRTSRRRGVVKQDVPATPPSDAEPSPKQHRLGTQR 302
              .....||.|:...::.  :.||:  :..|..:::|...|..:...|.|          :..::
Human   223 --SWGSFHQNPLLCTQKI--IPKEE--KVHKHDTQKRSFKKNLMAIKPKS----------VCAEK 271

  Fly   303 KLSAPRAGTVNGPSTTSGAATTPELKYHCDRCNAGFAVEKSLMIHRR-QKGCINRNYKCNECEKV 366
            ||                      ||  |:.|...|:...||.:|:| ..|  .:.|||.||.|.
Human   272 KL----------------------LK--CNDCEKVFSQSSSLTLHQRIHTG--EKPYKCIECGKA 310

  Fly   367 FVSPDHLAEHQASHGA---HNCPECGIRCDSKEALSK--HMVQG---HKRNLRNQCNICQKVFTM 423
            |....:|.:||..|..   :.|.||      ::|.|:  |:||.   |......:|.:|:|.|:.
Human   311 FSQRSNLVQHQRIHTGEKPYECKEC------RKAFSQNAHLVQHLRVHTGEKPYECKVCRKAFSQ 369

  Fly   424 LSTLRDHMRIHTGEKPFVCNICGKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHAR 488
            .:.|..|.|:||||||:.|..|||:|:..:::.||:..|:..|.::|.:|..:|..:|.||.|.|
Human   370 FAYLAQHQRVHTGEKPYECIECGKAFSNRSSIAQHQRVHTGEKPYECNVCGKAFSLRAYLTVHQR 434

  Fly   489 THTGDKPFECEVCLARFTTSCSLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYV 553
            .|||::|:||:.|...|:.:..||:|:|.||||:||.|..|...|:.:..|..|:|.||||:||.
Human   435 IHTGERPYECKECGKAFSQNSHLAQHQRIHTGEKPYKCQECRKAFSQIAYLAQHQRVHTGEKPYE 499

  Fly   554 CPFCSKTFTQRGDCQMHQRTHQGERIYICPVCNEEFKSMPEMRSHLAGH 602
            |..|.|.|:.......|||.|.||:.|.|.||.:.|.....:..|...|
Human   500 CIECGKAFSNDSSLTQHQRVHTGEKPYECTVCGKAFSYCGSLAQHQRIH 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	8/23 (35%)
		COG5048	<357..570	CDD:227381	84/220 (38%)
		C2H2 Zn finger	360..380	CDD:275368	8/19 (42%)
		C2H2 Zn finger	385..406	CDD:275370	8/25 (32%)
		C2H2 Zn finger	414..434	CDD:275368	7/19 (37%)
		zf-H2C2_2	427..451	CDD:290200	14/23 (61%)
		C2H2 Zn finger	442..490	CDD:275368	17/47 (36%)
		C2H2 Zn finger	470..487	CDD:275368	6/16 (38%)
		zf-H2C2_2	482..507	CDD:290200	12/24 (50%)
		C2H2 Zn finger	498..518	CDD:275368	7/19 (37%)
		zf-H2C2_2	510..534	CDD:290200	12/23 (52%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		zf-H2C2_2	539..563	CDD:290200	13/23 (57%)
		C2H2 Zn finger	554..574	CDD:275368	7/19 (37%)
		C2H2 Zn finger	582..602	CDD:275368	5/19 (26%)
ZNF570	NP_001287922.1	KRAB	70..130	CDD:214630
		C2H2 Zn finger	276..296	CDD:275368	7/19 (37%)
		zf-H2C2_2	288..313	CDD:316026	12/26 (46%)
		C2H2 Zn finger	304..324	CDD:275368	8/19 (42%)
		COG5048	<307..572	CDD:227381	93/248 (38%)
		C2H2 Zn finger	332..352	CDD:275368	8/25 (32%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
		C2H2 Zn finger	388..408	CDD:275368	7/19 (37%)
		C2H2 Zn finger	416..436	CDD:275368	8/19 (42%)
		C2H2 Zn finger	444..464	CDD:275368	7/19 (37%)
		C2H2 Zn finger	472..492	CDD:275368	6/19 (32%)
		C2H2 Zn finger	500..520	CDD:275368	7/19 (37%)
		C2H2 Zn finger	528..548	CDD:275368	5/19 (26%)
		C2H2 Zn finger	556..576	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910