DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6654 and ZNF420

DIOPT Version :9

Sequence 1:NP_650429.1 Gene:CG6654 / 41831 FlyBaseID:FBgn0038301 Length:639 Species:Drosophila melanogaster
Sequence 2:NP_001316444.1 Gene:ZNF420 / 147923 HGNCID:20649 Length:704 Species:Homo sapiens


Alignment Length:660 Identity:167/660 - (25%)
Similarity:252/660 - (38%) Gaps:178/660 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   110 WEPDRCTASVQTDAVTTTDAEQNTSLIKSTI-----SVDLDYEG---EGEVFDYELPDE----PV 162
            ||   |..|.|.|.......|..::|:...:     |.||..|.   |.|:..:|:.|.    .:
Human    20 WE---CLDSAQRDLYRDVMLENYSNLVSLDLPSRCASKDLSPEKNTYETELSQWEMSDRLENCDL 81

  Fly   163 EKTTSL-ILQVQGNLKDEKE---VVFTQTNVIYEG----DDH------------ELEQQIRECNL 207
            |::.|. .|:.:|.::.::|   ..|.|..:||:.    :.|            |...:.:||..
Human    82 EESNSRDYLEAKGKMEKQQENQKEYFRQGMIIYDKMSIFNQHTYLSQHSRCHSTEKPYKCKECGK 146

  Fly   208 AIFEGVDNEAEIITVTAPQVTTRKSAAKLLTQQENDKHQTPVGSKEEARELEKE----------- 261
            |.                     :.|:.|...|.....:.|...|:..:...::           
Human   147 AF---------------------RRASHLTQHQSIHTGEKPYECKQCGKAFSRDSQLSLHQRLHT 190

  Fly   262 -QVPQSAKRTSRRRGVVKQDV------PATPPSDAEPSPK----QHRLGTQRKL----------S 305
             :.|.:.|...:......|.:      ....|...|...|    ..:|...:|:          .
Human   191 GEKPYACKECGKAFTQSSQLILHHRIHTGEKPYKCEECGKAFIRSSQLTRHQKVHTGEKPYECKE 255

  Fly   306 APRAGTVNGPSTTSGAATTPELKYHCDRCNAGFAVEKSLMIHRR-QKGCINRNYKCNECEKVFVS 369
            ..:|.|.|...|......|.|..|.|..|...|.....|::|:| ..|  .:.|:|.||.|.|:.
Human   256 CGKAFTQNSQLTLHQRLHTGEKLYECKECRKVFTQLSQLILHKRIHTG--EKPYECKECGKAFIC 318

  Fly   370 PDHLAEHQASHGA---HNCPECG--------------IRCDSK----EALSKHMVQG-----HKR 408
            ...|::||..|..   :.|.|||              |....|    |...|..::|     |:|
Human   319 GSQLSQHQKIHNGEKPYECKECGRAFIRGSLLMQHQRIHTGEKPYKCEECGKAFIRGSQLTQHQR 383

  Fly   409 NLRN--------------------------------QCNICQKVFTMLSTLRDHMRIHTGEKPFV 441
            ...|                                ||..|.|.|...|.|..|.||||||||:.
Human   384 IHTNEKPYECKECGKMFSHGSQLTQHQRIHTGEKPYQCKECGKAFNRGSLLTRHQRIHTGEKPYE 448

  Fly   442 CNICGKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFT 506
            |..|||:|::.:.|.||:..|:..|.::|:.|..||:..::||.|.|.|||:||:||:.|...||
Human   449 CKECGKTFSRGSELTQHERIHTGEKPYECKECGKSFIRGSQLTQHQRIHTGEKPYECKECRMAFT 513

  Fly   507 TSCSLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQ 571
            .|..|::|:|.||||:||.|:.|...|....:|..|:|.||||:||.|..|.|.|.:......||
Human   514 QSSHLSQHQRLHTGEKPYVCNECGKAFARGLLLIQHQRIHTGEKPYQCKECGKAFIRGSQLTQHQ 578

  Fly   572 RTHQGERIYICPVCNEEFKSMPEM------------------------RSHLAGHEQHDKRLVHF 612
            |.|.||:.|.|..|.:.|....::                        .|||:.|::     :|.
Human   579 RIHTGEKPYECKECGKAFSHGSQLTLHQRIHTGEKPYECRECRKAFTQSSHLSRHQR-----IHT 638

  Fly   613 TFLSNKENGS 622
            .||:.:::.|
Human   639 AFLAGQQDRS 648

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6654NP_650429.1 zf-AD 6..79 CDD:285071
C2H2 Zn finger 331..354 CDD:275368 7/23 (30%)
COG5048 <357..570 CDD:227381 92/270 (34%)
C2H2 Zn finger 360..380 CDD:275368 8/19 (42%)
C2H2 Zn finger 385..406 CDD:275370 9/43 (21%)
C2H2 Zn finger 414..434 CDD:275368 8/19 (42%)
zf-H2C2_2 427..451 CDD:290200 15/23 (65%)
C2H2 Zn finger 442..490 CDD:275368 18/47 (38%)
C2H2 Zn finger 470..487 CDD:275368 6/16 (38%)
zf-H2C2_2 482..507 CDD:290200 13/24 (54%)
C2H2 Zn finger 498..518 CDD:275368 8/19 (42%)
zf-H2C2_2 510..534 CDD:290200 11/23 (48%)
C2H2 Zn finger 526..546 CDD:275368 6/19 (32%)
zf-H2C2_2 539..563 CDD:290200 13/23 (57%)
C2H2 Zn finger 554..574 CDD:275368 7/19 (37%)
C2H2 Zn finger 582..602 CDD:275368 6/43 (14%)
ZNF420NP_001316444.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.000

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