DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZNF543

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_998763.2	Gene:	ZNF543 / 125919	HGNCID:	25281	Length:	600	Species:	Homo sapiens

Alignment Length:	511	Identity:	150/511 - (29%)
Similarity:	219/511 - (42%)	Gaps:	77/511 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 AEQNTSLIKSTISVDLDYE--GEGEVFDYELPDEPVEKTTSLILQVQGNL-KDEKEVVFTQTNVI 190
            |....|:....::|....|  |:.:.....|..|.:.:|..|::.:...| |.|         :|
Human     3 ASAQVSVTFEDVAVTFTQEEWGQLDAAQRTLYQEVMLETCGLLMSLGCPLFKPE---------LI 58

  Fly   191 YEGDD-HELEQQIRECNLAIFEGVDNEAEIITVTAPQVTTRKSAAKLLTQQENDKHQTPVGSKEE 254
            |:.|. .||....::.:.:.:.| ||       |.|: ||..:.:.|...:|
Human    59 YQLDHRQELWMATKDLSQSSYPG-DN-------TKPK-TTEPTFSHLALPEE------------- 101

  Fly   255 ARELEKEQVPQSAKRTSRRRGVVKQDVPATPPSDAEPSPKQHRLGTQR-----KLSAPRAG---- 310
              .|.:||:.|.|.:.|:......||    .||:.:....:..:|.||     |:|:.|.|
Human   102 --VLLQEQLTQGASKNSQLGQSKDQD----GPSEMQEVHLKIGIGPQRGKLLEKMSSERDGLGSD 160

  Fly   311 ---------------------TVNGPSTTSGAATTPELKYHCDRCNAGFAVEKSLMIHRRQKGCI 354
                                 ..:|| .|.......:..|.|:.|...|.....|:.|.|....:
Human   161 DGVCTKITQKQVSTEGDLYECDSHGP-VTDALIREEKNSYKCEECGKVFKKNALLVQHERIHTQV 224

  Fly   355 NRNYKCNECEKVFVSPDHLAEHQASHGA---HNCPECGIRCDSKEALSKHMVQGHKRNLRNQCNI 416
             :.|:|.||.|.|....||.:|...|..   :.|.|||...:.:..|::|. :.|......:|:.
Human   225 -KPYECTECGKTFSKSTHLLQHLIIHTGEKPYKCMECGKAFNRRSHLTRHQ-RIHSGEKPYKCSE 287

  Fly   417 CQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKA 481
            |.|.||..||...|.|.|||||||||..|||:|.......:|.:.|:..|.::|..|..:|..::
Human   288 CGKAFTHRSTFVLHHRSHTGEKPFVCKECGKAFRDRPGFIRHYIIHTGEKPYECIECGKAFNRRS 352

  Fly   482 ELTSHARTHTGDKPFECEVCLARFTTSCSLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTH 546
            .||.|.:.|||.|||||..|...|..|..|.:|...||||:||.|..|...|...:.||.|:|.|
Human   353 YLTWHQQIHTGVKPFECNECGKAFCESADLIQHYIIHTGEKPYKCMECGKAFNRRSHLKQHQRIH 417

  Fly   547 TGERPYVCPFCSKTFTQRGDCQMHQRTHQGERIYICPVCNEEFKSMPEMRSHLAGH 602
            |||:||.|..|.|.||......:|:|||.||:.|.|..|.:.|....::..|.:.|
Human   418 TGEKPYECSECGKAFTHCSTFVLHKRTHTGEKPYECKECGKAFSDRADLIRHFSIH 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	6/22 (27%)
		COG5048	<357..570	CDD:227381	85/215 (40%)
		C2H2 Zn finger	360..380	CDD:275368	8/19 (42%)
		C2H2 Zn finger	385..406	CDD:275370	6/20 (30%)
		C2H2 Zn finger	414..434	CDD:275368	9/19 (47%)
		zf-H2C2_2	427..451	CDD:290200	15/23 (65%)
		C2H2 Zn finger	442..490	CDD:275368	14/47 (30%)
		C2H2 Zn finger	470..487	CDD:275368	5/16 (31%)
		zf-H2C2_2	482..507	CDD:290200	13/24 (54%)
		C2H2 Zn finger	498..518	CDD:275368	6/19 (32%)
		zf-H2C2_2	510..534	CDD:290200	10/23 (43%)
		C2H2 Zn finger	526..546	CDD:275368	7/19 (37%)
		zf-H2C2_2	539..563	CDD:290200	14/23 (61%)
		C2H2 Zn finger	554..574	CDD:275368	7/19 (37%)
		C2H2 Zn finger	582..602	CDD:275368	4/19 (21%)
ZNF543	NP_998763.2	KRAB	9..69	CDD:214630	15/68 (22%)
		COG5048	<75..329	CDD:227381	75/284 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	110..131		7/24 (29%)
		C2H2 Zn finger	201..221	CDD:275368	6/19 (32%)
		COG5048	223..562	CDD:227381	97/253 (38%)
		C2H2 Zn finger	229..249	CDD:275368	8/19 (42%)
		C2H2 Zn finger	257..277	CDD:275368	6/20 (30%)
		C2H2 Zn finger	285..305	CDD:275368	9/19 (47%)
		C2H2 Zn finger	313..333	CDD:275368	6/19 (32%)
		C2H2 Zn finger	341..361	CDD:275368	6/19 (32%)
		C2H2 Zn finger	369..389	CDD:275368	6/19 (32%)
		C2H2 Zn finger	397..417	CDD:275368	7/19 (37%)
		C2H2 Zn finger	425..445	CDD:275368	7/19 (37%)
		C2H2 Zn finger	453..473	CDD:275368	4/19 (21%)
		C2H2 Zn finger	481..501	CDD:275368
		C2H2 Zn finger	509..529	CDD:275368
		C2H2 Zn finger	537..557	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910