DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZNF816

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001026835.1	Gene:	ZNF816 / 125893	HGNCID:	26995	Length:	651	Species:	Homo sapiens

Alignment Length:	310	Identity:	112/310 - (36%)
Similarity:	151/310 - (48%)	Gaps:	33/310 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   324 TPELKYHCDRCNAGFAVEKSLMIHRR-QKGCINRNYKCNECEKVFVSPDHLAEHQASHGA---HN 384
            |.|..|.|:.|...|:.:.||..||| ..|  .:.||||||.|.|.....|..|:|.|..   :.
Human   308 TGEKPYKCNECGKTFSEKSSLRCHRRLHTG--EKPYKCNECGKTFGRNSALVIHKAIHTGEKPYK 370

  Fly   385 CPECGIRCDSKEALSKHMV-------------------QGHKRNLRN--------QCNICQKVFT 422
            |.|||.....|.:|..|.:                   :.|....|.        :|.:|.|||.
Human   371 CNECGKTFSQKSSLQCHHILHTGEKPYKCEECDNVYIRRSHLERHRKIHTGEGSYKCKVCDKVFR 435

  Fly   423 MLSTLRDHMRIHTGEKPFVCNICGKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHA 487
            ..|.|.:|.|:||||||:.||.||:||::.::|:.|...|:..|.:.|..|...|..:..|..|.
Human   436 SDSYLAEHQRVHTGEKPYKCNKCGRSFSRKSSLQYHHTLHTGEKPYTCNECGKVFSRRENLARHH 500

  Fly   488 RTHTGDKPFECEVCLARFTTSCSLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPY 552
            |.|.|:||::||.|...|:....|.:|:|.||||:||.|.:|...|.:.:.|.||.|.||||:||
Human   501 RLHAGEKPYKCEECDKVFSRRSHLERHRRIHTGEKPYKCKVCDKAFRSDSCLANHTRVHTGEKPY 565

  Fly   553 VCPFCSKTFTQRGDCQMHQRTHQGERIYICPVCNEEFKSMPEMRSHLAGH 602
            .|..|:|.|.|:|....|||.|.||:.|.|..|.:.|.....:..|...|
Human   566 KCNKCAKVFNQKGILAQHQRVHTGEKPYKCNECGKVFNQKASLAKHQRVH 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	9/23 (39%)
		COG5048	<357..570	CDD:227381	88/242 (36%)
		C2H2 Zn finger	360..380	CDD:275368	9/19 (47%)
		C2H2 Zn finger	385..406	CDD:275370	7/39 (18%)
		C2H2 Zn finger	414..434	CDD:275368	9/19 (47%)
		zf-H2C2_2	427..451	CDD:290200	15/23 (65%)
		C2H2 Zn finger	442..490	CDD:275368	16/47 (34%)
		C2H2 Zn finger	470..487	CDD:275368	4/16 (25%)
		zf-H2C2_2	482..507	CDD:290200	11/24 (46%)
		C2H2 Zn finger	498..518	CDD:275368	7/19 (37%)
		zf-H2C2_2	510..534	CDD:290200	11/23 (48%)
		C2H2 Zn finger	526..546	CDD:275368	7/19 (37%)
		zf-H2C2_2	539..563	CDD:290200	14/23 (61%)
		C2H2 Zn finger	554..574	CDD:275368	9/19 (47%)
		C2H2 Zn finger	582..602	CDD:275368	4/19 (21%)
ZNF816	NP_001026835.1	KRAB	24..64	CDD:307490
		C2H2 Zn finger	232..251	CDD:275368
		C2H2 Zn finger	259..279	CDD:275368
		COG5048	283..650	CDD:227381	112/310 (36%)
		C2H2 Zn finger	287..307	CDD:275368
		C2H2 Zn finger	315..335	CDD:275368	8/19 (42%)
		C2H2 Zn finger	343..363	CDD:275368	9/19 (47%)
		C2H2 Zn finger	371..391	CDD:275368	7/19 (37%)
		C2H2 Zn finger	399..419	CDD:275368	2/19 (11%)
		C2H2 Zn finger	427..447	CDD:275368	9/19 (47%)
		C2H2 Zn finger	455..475	CDD:275368	8/19 (42%)
		C2H2 Zn finger	483..503	CDD:275368	6/19 (32%)
		C2H2 Zn finger	511..531	CDD:275368	7/19 (37%)
		C2H2 Zn finger	539..559	CDD:275368	7/19 (37%)
		C2H2 Zn finger	567..587	CDD:275368	9/19 (47%)
		C2H2 Zn finger	595..615	CDD:275368	4/19 (21%)
		C2H2 Zn finger	623..643	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910